Showing Protein Ectonucleoside triphosphate diphosphohydrolase 5 (BMDBP02934)
| Identification | |||||||
|---|---|---|---|---|---|---|---|
| BMDB Protein ID | BMDBP02934 | ||||||
| Secondary Accession Numbers | None | ||||||
| Name | Ectonucleoside triphosphate diphosphohydrolase 5 | ||||||
| Synonyms | Not Available | ||||||
| Gene Name | ENTPD5 | ||||||
| Protein Type | Enzyme | ||||||
| Biological Properties | |||||||
| General Function | Not Available | ||||||
| Specific Function | Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling (By similarity). | ||||||
| Pathways | Not Available | ||||||
| Reactions |
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| GO Classification | Not Available | ||||||
| Cellular Location | Not Available | ||||||
| Gene Properties | |||||||
| Chromosome Location | Not Available | ||||||
| Locus | Not Available | ||||||
| SNPs | ENTPD5 | ||||||
| Gene Sequence | Not Available | ||||||
| Protein Properties | |||||||
| Number of Residues | 432 | ||||||
| Molecular Weight | 47888.0 | ||||||
| Theoretical pI | Not Available | ||||||
| Pfam Domain Function | Not Available | ||||||
| Signals |
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| Transmembrane Regions | Not Available | ||||||
| Protein Sequence | Not Available | ||||||
| External Links | |||||||
| GenBank ID Protein | Not Available | ||||||
| UniProtKB/Swiss-Prot ID | E1BPW0 | ||||||
| UniProtKB/Swiss-Prot Entry Name | ENTP5_BOVIN | ||||||
| PDB IDs | Not Available | ||||||
| GenBank Gene ID | AAFC03056279 | ||||||
| GeneCard ID | ENTPD5 | ||||||
| GenAtlas ID | Not Available | ||||||
| HGNC ID | Not Available | ||||||
| References | |||||||
| General References | Not Available | ||||||