Identification
BMDB Protein ID BMDBP02949
Secondary Accession Numbers None
Name Synaptojanin-1
Synonyms Not Available
Gene Name SYNJ1
Protein Type Enzyme
Biological Properties
General Function Not Available
Specific Function Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (PubMed:9199318).
Pathways Not Available
Reactions
Inositol 1,3,4,5-tetraphosphate + Water → 1D-Myo-inositol 1,4-bisphosphate + Hydrogen phosphate details
Inositol 1,3,4,5-tetraphosphate + Water → Inositol 1,3,4-trisphosphate + Hydrogen phosphate details
Inositol 1,4,5-trisphosphate + Water → 1D-Myo-inositol 1,4-bisphosphate + Hydrogen phosphate details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs SYNJ1
Gene Sequence Not Available
Protein Properties
Number of Residues 1324
Molecular Weight 146584.0
Theoretical pI Not Available
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein BAA21652.1
UniProtKB/Swiss-Prot ID O18964
UniProtKB/Swiss-Prot Entry Name SYNJ1_BOVIN
PDB IDs Not Available
GenBank Gene ID D85682
GeneCard ID SYNJ1
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available