Showing Protein [F-actin]-monooxygenase MICAL1 (BMDBP03179)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP03179 |
| Secondary Accession Numbers |
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| Name | [F-actin]-monooxygenase MICAL1 |
| Synonyms | Not Available |
| Gene Name | MICAL1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Not Available |
| Specific Function | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 9 |
| Locus | Not Available |
| SNPs | MICAL1 |
| Gene Sequence | Not Available |
| Protein Properties | |
| Number of Residues | 1070 |
| Molecular Weight | 118696.0 |
| Theoretical pI | Not Available |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions | Not Available |
| Protein Sequence | Not Available |
| External Links | |
| GenBank ID Protein | AAI33299.1 |
| UniProtKB/Swiss-Prot ID | F1MH07 |
| UniProtKB/Swiss-Prot Entry Name | MICA1_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | DAAA02025917 |
| GeneCard ID | MICAL1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |