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Showing Protein Phospholipase A2, membrane associated (BMDBP03194)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP03194 | ||
| Secondary Accession Numbers |
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| Name | Phospholipase A2, membrane associated | ||
| Synonyms | Not Available | ||
| Gene Name | PLA2G2A | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Not Available | ||
| Specific Function | Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferation in an integrin-dependent manner. | ||
| Pathways | Not Available | ||
| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 2 | ||
| Locus | Not Available | ||
| SNPs | PLA2G2A | ||
| Gene Sequence | Not Available | ||
| Protein Properties | |||
| Number of Residues | 144 | ||
| Molecular Weight | 16347.0 | ||
| Theoretical pI | Not Available | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence | Not Available | ||
| External Links | |||
| GenBank ID Protein | AAW82103.1 | ||
| UniProtKB/Swiss-Prot ID | Q56JZ2 | ||
| UniProtKB/Swiss-Prot Entry Name | PA2GA_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | AY911335 | ||
| GeneCard ID | PLA2G2A | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||