Showing Protein Phospholipase A2, membrane associated (BMDBP03194)
Identification | |||
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BMDB Protein ID | BMDBP03194 | ||
Secondary Accession Numbers |
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Name | Phospholipase A2, membrane associated | ||
Synonyms | Not Available | ||
Gene Name | PLA2G2A | ||
Protein Type | Enzyme | ||
Biological Properties | |||
General Function | Not Available | ||
Specific Function | Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferation in an integrin-dependent manner. | ||
Pathways | Not Available | ||
Reactions |
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GO Classification | Not Available | ||
Cellular Location | Not Available | ||
Gene Properties | |||
Chromosome Location | 2 | ||
Locus | Not Available | ||
SNPs | PLA2G2A | ||
Gene Sequence | Not Available | ||
Protein Properties | |||
Number of Residues | 144 | ||
Molecular Weight | 16347.0 | ||
Theoretical pI | Not Available | ||
Pfam Domain Function | Not Available | ||
Signals |
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Transmembrane Regions | Not Available | ||
Protein Sequence | Not Available | ||
External Links | |||
GenBank ID Protein | AAW82103.1 | ||
UniProtKB/Swiss-Prot ID | Q56JZ2 | ||
UniProtKB/Swiss-Prot Entry Name | PA2GA_BOVIN | ||
PDB IDs | Not Available | ||
GenBank Gene ID | AY911335 | ||
GeneCard ID | PLA2G2A | ||
GenAtlas ID | Not Available | ||
HGNC ID | Not Available | ||
References | |||
General References | Not Available |