Identification
BMDB Protein ID BMDBP03194
Secondary Accession Numbers
  • BMDBP02916
Name Phospholipase A2, membrane associated
Synonyms Not Available
Gene Name PLA2G2A
Protein Type Enzyme
Biological Properties
General Function Not Available
Specific Function Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1. Induces cell proliferation in an integrin-dependent manner.
Pathways Not Available
Reactions
PC(16:0/16:0) → LysoPC(16:0/0:0) details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 2
Locus Not Available
SNPs PLA2G2A
Gene Sequence Not Available
Protein Properties
Number of Residues 144
Molecular Weight 16347.0
Theoretical pI Not Available
Pfam Domain Function Not Available
Signals
  • 1-20
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein AAW82103.1
UniProtKB/Swiss-Prot ID Q56JZ2
UniProtKB/Swiss-Prot Entry Name PA2GA_BOVIN
PDB IDs Not Available
GenBank Gene ID AY911335
GeneCard ID PLA2G2A
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available