Identification
BMDB Protein ID BMDBP03202
Secondary Accession Numbers
  • BMDBP03012
Name Coagulation factor XII
Synonyms Not Available
Gene Name F12
Protein Type Enzyme
Biological Properties
General Function Not Available
Specific Function Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity).
Pathways Not Available
Reactions
Coagulation factor XI → Coagulation factor XIa details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs F12
Gene Sequence Not Available
Protein Properties
Number of Residues 612
Molecular Weight 67160.0
Theoretical pI Not Available
Pfam Domain Function Not Available
Signals
  • 1-19
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein AAI20001.1
UniProtKB/Swiss-Prot ID P98140
UniProtKB/Swiss-Prot Entry Name FA12_BOVIN
PDB IDs Not Available
GenBank Gene ID BC120000
GeneCard ID F12
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available