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Record Information |
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Version | 1.0 |
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Creation Date | 2016-09-30 22:19:40 UTC |
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Update Date | 2020-05-21 16:27:01 UTC |
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BMDB ID | BMDB0000107 |
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Secondary Accession Numbers | |
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Metabolite Identification |
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Common Name | Galactitol |
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Description | Galactitol, also known as dulcitol or melampyrit, belongs to the class of organic compounds known as sugar alcohols. These are hydrogenated forms of carbohydrate in which the carbonyl group (aldehyde or ketone, reducing sugar) has been reduced to a primary or secondary hydroxyl group. Galactitol exists as a solid, possibly soluble (in water), and an extremely weak basic (essentially neutral) compound (based on its pKa) molecule. Galactitol exists in all living organisms, ranging from bacteria to humans. Galactitol can be biosynthesized from D-galactose; which is mediated by the enzyme aldose reductase. In cattle, galactitol is involved in the metabolic pathway called the galactose metabolism pathway. Galactitol is a potentially toxic compound. |
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Structure | |
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Synonyms | Value | Source |
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(2R,3S,4R,5S)-Hexane-1,2,3,4,5,6-hexol | ChEBI | D-Dulcitol | ChEBI | D-Galactitol | ChEBI | Dulcitol | ChEBI | Dulcose | ChEBI | Euonymit | ChEBI | L-Galactitol | ChEBI | Melampyrin | ChEBI | Melampyrit | ChEBI | Ambap5938 | HMDB | Dulcite | HMDB | Hexitol | HMDB | Melampyrite | HMDB | Melampyrum | HMDB | meso-Galactitol | HMDB |
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Chemical Formula | C6H14O6 |
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Average Molecular Weight | 182.1718 |
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Monoisotopic Molecular Weight | 182.07903818 |
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IUPAC Name | Not Available |
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Traditional Name | Not Available |
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CAS Registry Number | 608-66-2 |
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SMILES | Not Available |
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InChI Identifier | InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5+,6- |
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InChI Key | FBPFZTCFMRRESA-GUCUJZIJSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of organic compounds known as sugar alcohols. These are hydrogenated forms of carbohydrate in which the carbonyl group (aldehyde or ketone, reducing sugar) has been reduced to a primary or secondary hydroxyl group. |
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Kingdom | Organic compounds |
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Super Class | Organic oxygen compounds |
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Class | Organooxygen compounds |
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Sub Class | Carbohydrates and carbohydrate conjugates |
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Direct Parent | Sugar alcohols |
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Alternative Parents | |
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Substituents | - Sugar alcohol
- Monosaccharide
- Secondary alcohol
- Polyol
- Hydrocarbon derivative
- Primary alcohol
- Alcohol
- Aliphatic acyclic compound
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Molecular Framework | Aliphatic acyclic compounds |
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External Descriptors | |
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Ontology |
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Status | Detected but not Quantified |
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Origin | |
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Biofunction | Not Available |
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Application | Not Available |
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Cellular locations | |
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Physical Properties |
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State | Solid |
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Experimental Properties | Property | Value | Reference |
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Melting Point | 189.5 °C | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | 31,0 mg/mL at 15 °C | YALKOWSKY,SH & DANNENFELSER,RM (1992) | LogP | -3.1 | HANSCH,C ET AL. (1995) |
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Predicted Properties | Not Available |
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Spectra |
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Spectra | |
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Biological Properties |
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Cellular Locations | |
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Biospecimen Locations | - Brain
- Erythrocyte
- Eye Lens
- Milk
- Semen
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Pathways | |
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Normal Concentrations |
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Brain | Expected but not Quantified | Not Quantified | Not Specified | Not Specified | Normal | | details | Erythrocyte | Expected but not Quantified | Not Quantified | Not Specified | Not Specified | Normal | | details | Eye Lens | Expected but not Quantified | Not Quantified | Not Specified | Not Specified | Normal | | details | Milk | Detected but not Quantified | Not Quantified | Not Specified | Not Specified | Normal | | details | Semen | Detected but not Quantified | Not Quantified | Not Specified | Not Specified | Normal | | details |
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Abnormal Concentrations |
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| Not Available |
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External Links |
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HMDB ID | HMDB0000107 |
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DrugBank ID | Not Available |
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Phenol Explorer Compound ID | Not Available |
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FooDB ID | FDB006453 |
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KNApSAcK ID | C00001160 |
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Chemspider ID | 11357 |
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KEGG Compound ID | C01697 |
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BioCyc ID | Not Available |
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BiGG ID | 38183 |
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Wikipedia Link | Galactitol |
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METLIN ID | 5148 |
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PubChem Compound | 11850 |
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PDB ID | Not Available |
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ChEBI ID | 16813 |
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References |
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Synthesis Reference | Muniruzzaman, Syed; Itoh, Hiromichi; Yoshino, Akira; Katayama, Takeshi; Izumori, Ken. Biotransformation of lactose to galactitol. Journal of Fermentation and Bioengineering (1994), 77(1), 32-5. |
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Material Safety Data Sheet (MSDS) | Not Available |
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General References | - Melzer N, Wittenburg D, Hartwig S, Jakubowski S, Kesting U, Willmitzer L, Lisec J, Reinsch N, Repsilber D: Investigating associations between milk metabolite profiles and milk traits of Holstein cows. J Dairy Sci. 2013 Mar;96(3):1521-34. doi: 10.3168/jds.2012-5743. [PubMed:23438684 ]
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