Showing metabocard for Histamine (BMDB0000870)

General function:

Secondary metabolites biosynthesis, transport and catabolism

Specific function:

Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity (By similarity).

Gene Name:

AOC3

Uniprot ID:

Q9TTK6

Molecular weight:

84500.0

Reactions

General function:

Involved in histamine N-methyltransferase activity

Specific function:

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.

Gene Name:

HNMT

Uniprot ID:

Q58DV7

Molecular weight:

33646.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the biosynthesis of histamine from histidine.

Gene Name:

HDC

Uniprot ID:

Q5EA83

Molecular weight:

73912.0

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.

Gene Name:

SLC18A2

Uniprot ID:

Q27963

Molecular weight:

55756.0

General function:

Involved in histamine receptor activity

Specific function:

Not Available

Gene Name:

HRH1

Uniprot ID:

A5D795

Molecular weight:

55989.0

General function:

Involved in histamine receptor activity

Specific function:

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

Gene Name:

HRH1

Uniprot ID:

P30546

Molecular weight:

55957.0