Showing metabocard for S-Adenosylmethioninamine (BMDB0000988)

IdentificationTaxonomyPhysical propertiesPathwaysSpectraConcentrationsLinksReferencesenzymes (3) Show 3 proteinsXML
Record Information
Version1.0
Creation Date2016-09-30 22:39:30 UTC
Update Date2020-05-21 16:29:03 UTC
BMDB IDBMDB0000988
Secondary Accession Numbers
  • BMDB00988
Metabolite Identification
Common NameS-Adenosylmethioninamine
DescriptionS-Adenosylmethioninamine, also known as decarboxy-adomet or dadomet, belongs to the class of organic compounds known as 5'-deoxy-5'-thionucleosides. These are 5'-deoxyribonucleosides in which the ribose is thio-substituted at the 5'position by a S-alkyl group. S-Adenosylmethioninamine exists in all living species, ranging from bacteria to plants to humans. Based on a literature review a small amount of articles have been published on S-Adenosylmethioninamine.
Structure
Thumb
MOLSDF3D-SDFPDBSMILESInChI View 3D Structure
Synonyms
ValueSource
(5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulfoniumChEBI
(5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium cationChEBI
(5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium saltChEBI
[1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl](3-aminopropyl)(methyl)sulfoniumChEBI
S-Adenosyl-(5')-3-methylthiopropylamineChEBI
S-Adenosyl-3-methylthiopropylamineChEBI
S-Adenosyl 3-(methylthio)propylamineKegg
S-Adenosyl 3-(methylsulfanyl)propylamineKegg
Decarboxy-adometKegg
(5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulphoniumGenerator
(5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulphonium cationGenerator
(5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulphonium saltGenerator
[1-(Adenin-9-yl)-1,5-dideoxy-b-D-ribofuranos-5-yl](3-aminopropyl)(methyl)sulfoniumGenerator
[1-(Adenin-9-yl)-1,5-dideoxy-b-D-ribofuranos-5-yl](3-aminopropyl)(methyl)sulphoniumGenerator
[1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl](3-aminopropyl)(methyl)sulphoniumGenerator
[1-(Adenin-9-yl)-1,5-dideoxy-β-D-ribofuranos-5-yl](3-aminopropyl)(methyl)sulfoniumGenerator
[1-(Adenin-9-yl)-1,5-dideoxy-β-D-ribofuranos-5-yl](3-aminopropyl)(methyl)sulphoniumGenerator
S-Adenosyl 3-(methylsulphanyl)propylamineGenerator
S--AdenosylmethioninamineHMDB
(5-Deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium saltHMDB
DAdoMetHMDB
Decarboxylated adometHMDB
Decarboxylated S-adenosylmethionineHMDB
Decarboxylated samHMDB
S-Adenosyl-L-methioninamineHMDB
S-5'-Deoxyadenosyl-(5')-3-methylthiopropylamineHMDB
S-Adenosyl(5')-3-methylthiopropylamineHMDB
(-)-S-Adenosyl-(5')-3-methylthiopropylamineHMDB
(-)-S-Adenosyl-(5’)-3-methylthiopropylamineHMDB
5'-[(3-Aminopropyl)methylsulfonio]-5'-deoxyadenosineHMDB
5’-[(3-aminopropyl)methylsulfonio]-5’-deoxyadenosineHMDB
S-Adenosyl-(5’)-3-methylthiopropylamineHMDB
S-Adenosyl-L-methionamineHMDB
S-AdenosylmethionamineHMDB
S-Methyl-S-adenosyl homocysteamineHMDB
S-Methyl-S-adenosylhomocysteamineHMDB
S-MethyladenosylhomocysteamineHMDB
S-AdenosylmethioninamineHMDB
Chemical FormulaC14H23N6O3S
Average Molecular Weight355.436
Monoisotopic Molecular Weight355.155234322
IUPAC Name{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(3-aminopropyl)methylsulfanium
Traditional Namedecarboxylated sam
CAS Registry Number22365-13-5
SMILES
C[S+](CCCN)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N
InChI Identifier
InChI=1S/C14H23N6O3S/c1-24(4-2-3-15)5-8-10(21)11(22)14(23-8)20-7-19-9-12(16)17-6-18-13(9)20/h6-8,10-11,14,21-22H,2-5,15H2,1H3,(H2,16,17,18)/q+1/t8-,10-,11-,14-,24?/m1/s1
InChI KeyZUNBITIXDCPNSD-LSRJEVITSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as 5'-deoxy-5'-thionucleosides. These are 5'-deoxyribonucleosides in which the ribose is thio-substituted at the 5'position by a S-alkyl group.
KingdomOrganic compounds
Super ClassNucleosides, nucleotides, and analogues
Class5'-deoxyribonucleosides
Sub Class5'-deoxy-5'-thionucleosides
Direct Parent5'-deoxy-5'-thionucleosides
Alternative Parents
Substituents
  • 5'-deoxy-5'-thionucleoside
  • Glycosyl compound
  • N-glycosyl compound
  • 6-aminopurine
  • Pentose monosaccharide
  • Purine
  • Imidazopyrimidine
  • Aminopyrimidine
  • Imidolactam
  • Pyrimidine
  • Monosaccharide
  • N-substituted imidazole
  • Heteroaromatic compound
  • Tetrahydrofuran
  • Azole
  • Imidazole
  • Secondary alcohol
  • 1,2-diol
  • Oxacycle
  • Azacycle
  • Organoheterocyclic compound
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Primary aliphatic amine
  • Organooxygen compound
  • Organosulfur compound
  • Organic oxygen compound
  • Organic nitrogen compound
  • Primary amine
  • Amine
  • Alcohol
  • Organic cation
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
StatusExpected but not Quantified
Origin
  • Endogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Cytoplasm
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP0.28ALOGPS
logP-2.8ChemAxon
logS-2.5ALOGPS
pKa (Strongest Acidic)12.45ChemAxon
pKa (Strongest Basic)10.09ChemAxon
Physiological Charge2ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area145.33 ŲChemAxon
Rotatable Bond Count6ChemAxon
Refractivity90.4 m³·mol⁻¹ChemAxon
Polarizability36.97 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Biological Properties
Cellular Locations
  • Cytoplasm
Biospecimen LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
HMDB IDHMDB0000988
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB022353
KNApSAcK IDNot Available
Chemspider ID388529
KEGG Compound IDC01137
BioCyc IDS-ADENOSYLMETHIONINAMINE
BiGG ID36895
Wikipedia LinkS-Adenosylmethioninamine
METLIN ID3501
PubChem Compound439415
PDB IDNot Available
ChEBI ID15625
References
Synthesis ReferencePegg, Anthony E. Assay of aminopropyltransferases. Methods in Enzymology (1983), 94(Polyamines), 260-5.
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

Enzyme Details
1. Spermine synthase
General function:
Amino acid transport and metabolism
Specific function:
Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM).
Gene Name:
SMS
Uniprot ID:
Q3SZA5
Molecular weight:
41224.0
Reactions
S-Adenosylmethioninamine + Spermidine → 5'-Methylthioadenosine + Sperminedetails
Enzyme Details
2. S-adenosylmethionine decarboxylase proenzyme
General function:
Involved in adenosylmethionine decarboxylase activity
Specific function:
Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
Gene Name:
AMD1
Uniprot ID:
P50243
Molecular weight:
38365.0
Reactions
S-Adenosylmethionine → S-Adenosylmethioninamine + Carbon dioxidedetails
Enzyme Details
3. Spermidine synthase
General function:
Not Available
Specific function:
Not Available
Gene Name:
SRM
Uniprot ID:
E1BM12
Molecular weight:
33981.0
Reactions
S-Adenosylmethioninamine + Putrescine → 5'-Methylthioadenosine + Spermidinedetails