Showing metabocard for 5-Diphosphomevalonic acid (BMDB0001090)

IdentificationTaxonomyPhysical propertiesPathwaysSpectraConcentrationsLinksReferencesenzymes (2) Show 2 proteinsXML
Record Information
Version1.0
Creation Date2016-09-30 22:40:58 UTC
Update Date2020-05-21 16:27:03 UTC
BMDB IDBMDB0001090
Secondary Accession Numbers
  • BMDB01090
Metabolite Identification
Common Name5-Diphosphomevalonic acid
Description(R)-5-Diphosphomevalonic acid, also known as mevalonate 5-diphosphate or mevalonic acid 5-pyrophosphate, belongs to the class of organic compounds known as organic pyrophosphates. These are organic compounds containing the pyrophosphate oxoanion, with the structure OP([O-])(=O)OP(O)([O-])=O (R)-5-Diphosphomevalonic acid is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral (R)-5-Diphosphomevalonic acid exists in all living species, ranging from bacteria to humans.
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
(R)-5-DiphosphomevalonateChEBI
5-DiphosphomevalonateHMDB
5-Diphosphomevalonic acidHMDB
Mevalonate 5-diphosphateHMDB
Mevalonate pyrophosphateHMDB
Mevalonate-diphosphateHMDB
(3R)-3-Hydroxy-5-[[hydroxy(phosphonooxy)phosphinyl]oxy]-3-methylpentanoic acidHMDB
(R)-Diphosphomevalonic acidHMDB
5-Pyrophosphomevalonic acidHMDB
Mevalonic 5-pyrophosphateHMDB
Mevalonic acid 5-diphosphateHMDB
Mevalonic acid 5-pyrophosphateHMDB
Mevalonic acid pyrophosphateHMDB
Pyrophosphomevalonic acidHMDB
(3R)-3-Hydroxy-5-[[hydroxy(phosphonooxy)phosphinyl]oxy]-3-methylpentanoateHMDB
(R)-DiphosphomevalonateHMDB
5-PyrophosphomevalonateHMDB
Mevalonate 5-pyrophosphateHMDB
Mevalonic 5-pyrophosphic acidHMDB
Mevalonic acid 5-diphosphic acidHMDB
Mevalonic acid 5-pyrophosphic acidHMDB
Mevalonic acid pyrophosphic acidHMDB
PyrophosphomevalonateHMDB
(R)-5-Diphosphomevalonic acidGenerator
R-DiphosphomevalonateHMDB
Chemical FormulaC6H14O10P2
Average Molecular Weight308.1169
Monoisotopic Molecular Weight308.006219692
IUPAC Name(3R)-3-hydroxy-5-{[hydroxy(phosphonooxy)phosphoryl]oxy}-3-methylpentanoic acid
Traditional Namemevalonate-diphosphate
CAS Registry NumberNot Available
SMILES
C[C@@](O)(CCOP(O)(=O)OP(O)(O)=O)CC(O)=O
InChI Identifier
InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
InChI KeySIGQQUBJQXSAMW-ZCFIWIBFSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as organic pyrophosphates. These are organic compounds containing the pyrophosphate oxoanion, with the structure OP([O-])(=O)OP(O)([O-])=O.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganic oxoanionic compounds
Sub ClassOrganic pyrophosphates
Direct ParentOrganic pyrophosphates
Alternative Parents
Substituents
  • Organic pyrophosphate
  • Monoalkyl phosphate
  • Short-chain hydroxy acid
  • Organic phosphoric acid derivative
  • Fatty acid
  • Alkyl phosphate
  • Phosphoric acid ester
  • Tertiary alcohol
  • Carboxylic acid derivative
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Carbonyl group
  • Alcohol
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
StatusExpected but not Quantified
OriginNot Available
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Peroxisome
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-1.2ALOGPS
logP-1.6ChemAxon
logS-1.6ALOGPS
pKa (Strongest Acidic)1.78ChemAxon
pKa (Strongest Basic)-2.9ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area170.82 ŲChemAxon
Rotatable Bond Count8ChemAxon
Refractivity56.26 m³·mol⁻¹ChemAxon
Polarizability23.46 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Biological Properties
Cellular Locations
  • Peroxisome
Biospecimen LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
HMDB IDHMDB0001090
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB031002
KNApSAcK IDC00007615
Chemspider ID388531
KEGG Compound IDC01143
BioCyc IDCPD-641
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound439418
PDB IDNot Available
ChEBI ID15899
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

Enzyme Details
1. Diphosphomevalonate decarboxylase
General function:
Lipid transport and metabolism
Specific function:
Performs the first committed step in the biosynthesis of isoprenes.
Gene Name:
MVD
Uniprot ID:
Q0P570
Molecular weight:
43732.0
Reactions
Adenosine triphosphate + 5-Diphosphomevalonic acid → ADP + Hydrogen phosphate + Isopentenyl pyrophosphate + Carbon dioxidedetails
Enzyme Details
2. Phosphomevalonate kinase
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
PMVK
Uniprot ID:
Q2KIU2
Molecular weight:
21956.0
Reactions
Adenosine triphosphate + Mevalonic acid-5P → ADP + 5-Diphosphomevalonic aciddetails