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Showing metabocard for Pyrroline hydroxycarboxylic acid (BMDB0001369)
Record Information | |||||||||||||||||||||
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Version | 1.0 | ||||||||||||||||||||
Creation Date | 2016-09-30 22:44:50 UTC | ||||||||||||||||||||
Update Date | 2020-05-21 16:28:29 UTC | ||||||||||||||||||||
BMDB ID | BMDB0001369 | ||||||||||||||||||||
Secondary Accession Numbers |
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Metabolite Identification | |||||||||||||||||||||
Common Name | Pyrroline hydroxycarboxylic acid | ||||||||||||||||||||
Description | Pyrroline hydroxycarboxylic acid, also known as L-1-pyrroline 3-hydroxy-5-carboxylate or 3-hydroxy-L-1-pyrroline-5-carboxylate, belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof. Pyrroline hydroxycarboxylic acid is a moderately basic compound (based on its pKa). Pyrroline hydroxycarboxylic acid exists in all living species, ranging from bacteria to humans. | ||||||||||||||||||||
Structure | |||||||||||||||||||||
Synonyms |
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Chemical Formula | C5H7NO3 | ||||||||||||||||||||
Average Molecular Weight | 129.114 | ||||||||||||||||||||
Monoisotopic Molecular Weight | 129.042593095 | ||||||||||||||||||||
IUPAC Name | Not Available | ||||||||||||||||||||
Traditional Name | Not Available | ||||||||||||||||||||
CAS Registry Number | 22573-88-2 | ||||||||||||||||||||
SMILES | Not Available | ||||||||||||||||||||
InChI Identifier | InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9) | ||||||||||||||||||||
InChI Key | WFOFKRKDDKGRIK-UHFFFAOYSA-N | ||||||||||||||||||||
Chemical Taxonomy | |||||||||||||||||||||
Description | belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof. | ||||||||||||||||||||
Kingdom | Organic compounds | ||||||||||||||||||||
Super Class | Organic acids and derivatives | ||||||||||||||||||||
Class | Carboxylic acids and derivatives | ||||||||||||||||||||
Sub Class | Amino acids, peptides, and analogues | ||||||||||||||||||||
Direct Parent | Alpha amino acids and derivatives | ||||||||||||||||||||
Alternative Parents | |||||||||||||||||||||
Substituents |
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Molecular Framework | Aliphatic heteromonocyclic compounds | ||||||||||||||||||||
External Descriptors |
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Ontology | |||||||||||||||||||||
Status | Expected but not Quantified | ||||||||||||||||||||
Origin |
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Biofunction | Not Available | ||||||||||||||||||||
Application | Not Available | ||||||||||||||||||||
Cellular locations |
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Physical Properties | |||||||||||||||||||||
State | Solid | ||||||||||||||||||||
Experimental Properties |
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Predicted Properties | Not Available | ||||||||||||||||||||
Spectra | |||||||||||||||||||||
Spectra |
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Biological Properties | |||||||||||||||||||||
Cellular Locations |
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Biospecimen Locations | Not Available | ||||||||||||||||||||
Pathways | |||||||||||||||||||||
Normal Concentrations | |||||||||||||||||||||
Not Available | |||||||||||||||||||||
Abnormal Concentrations | |||||||||||||||||||||
Not Available | |||||||||||||||||||||
External Links | |||||||||||||||||||||
HMDB ID | HMDB0001369 | ||||||||||||||||||||
DrugBank ID | Not Available | ||||||||||||||||||||
Phenol Explorer Compound ID | Not Available | ||||||||||||||||||||
FooDB ID | FDB022582 | ||||||||||||||||||||
KNApSAcK ID | Not Available | ||||||||||||||||||||
Chemspider ID | 1030 | ||||||||||||||||||||
KEGG Compound ID | C04281 | ||||||||||||||||||||
BioCyc ID | Not Available | ||||||||||||||||||||
BiGG ID | 43511 | ||||||||||||||||||||
Wikipedia Link | Not Available | ||||||||||||||||||||
METLIN ID | 6196 | ||||||||||||||||||||
PubChem Compound | 1059 | ||||||||||||||||||||
PDB ID | Not Available | ||||||||||||||||||||
ChEBI ID | 27391 | ||||||||||||||||||||
References | |||||||||||||||||||||
Synthesis Reference | Not Available | ||||||||||||||||||||
Material Safety Data Sheet (MSDS) | Not Available | ||||||||||||||||||||
General References | Not Available |
Enzymes
- General function:
- Amino acid transport and metabolism
- Specific function:
- Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity).
- Gene Name:
- PYCR2
- Uniprot ID:
- Q17QJ7
- Molecular weight:
- 33630.0
Reactions
Hydroxyproline + NAD → Pyrroline hydroxycarboxylic acid + NADH | details |