Showing metabocard for Putrescine (BMDB0001414)

General function:

Involved in electron carrier activity

Specific function:

Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration.

Gene Name:

PAOX

Uniprot ID:

Q865R1

Molecular weight:

56325.0

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.

Gene Name:

ODC1

Uniprot ID:

P27117

Molecular weight:

51346.0

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General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

ADC

Uniprot ID:

Q2TBX3

Molecular weight:

54147.0

General function:

Not Available

Specific function:

Not Available

Gene Name:

SRM

Uniprot ID:

E1BM12

Molecular weight:

33981.0

Reactions