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Record Information
Version1.0
Creation Date2016-09-30 22:46:15 UTC
Update Date2020-05-21 16:28:48 UTC
BMDB IDBMDB0001457
Secondary Accession Numbers
  • BMDB01457
Metabolite Identification
Common Name5-b-Cholestane-3a ,7a ,12a-triol
Description5beta-Cholestane-3alpha,7alpha,12alpha-triol, also known as 3alpha,7alpha,12alpha-trihydroxycoprostane or 3a,7a,12a-trihydroxy-5b-cholestane, belongs to the class of organic compounds known as cholesterols and derivatives. Cholesterols and derivatives are compounds containing a 3-hydroxylated cholestane core. Thus, 5beta-cholestane-3alpha,7alpha,12alpha-triol is considered to be a bile acid. Based on a literature review a small amount of articles have been published on 5beta-Cholestane-3alpha,7alpha,12alpha-triol.
Structure
Thumb
Synonyms
ValueSource
3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestaneChEBI
3alpha,7alpha,12alpha-TrihydroxycoprostaneChEBI
3a,7a,12a-Trihydroxy-5b-cholestaneGenerator
3Α,7α,12α-trihydroxy-5β-cholestaneGenerator
3a,7a,12a-TrihydroxycoprostaneGenerator
3Α,7α,12α-trihydroxycoprostaneGenerator
5b-Cholestane-3a,7a,12a-triolGenerator
5Β-cholestane-3α,7α,12α-triolGenerator
5-beta-Cholestane-3-alpha,7-alpha,12-alpha-triolHMDB
3,7,12-TrihydroxycholestaneMeSH, HMDB
3,7,12-TrihydroxycoprostaneMeSH, HMDB
3,7,12-Trihydroxycoprostane, (3alpha,5alpha,7alpha,12alpha)-isomerMeSH, HMDB
3,7,12-Trihydroxycoprostane, (3beta,5alpha,7alpha,12alpha)-isomerMeSH, HMDB
3,7,12-Trihydroxycoprostane, (3beta,5beta,7alpha,12alpha)-isomerMeSH, HMDB
3alpha, 7alpha,12alpha-Trihydroxy-5beta-cholestaneMeSH, HMDB
5 beta-Cholestane-3 alpha,7 alpha,12 alpha-triolMeSH, HMDB
5beta-Cholestane-3alpha,7alpha,12alpha-triolMeSH, KEGG
ChtriolMeSH, HMDB
TrihydroxycoprostaneMeSH, HMDB
(3alpha,5beta,7alpha,12alpha)-Cholestane-3,7,12-triolHMDB
(3α,5β,7α,12α)-Cholestane-3,7,12-triolHMDB
5beta-Cholestan-3alpha,7alpha,12alpha-triolHMDB
5β-Cholestan-3α,7α,12α-triolHMDB
Chemical FormulaC27H48O3
Average Molecular Weight420.6682
Monoisotopic Molecular Weight420.360345402
IUPAC NameNot Available
Traditional NameNot Available
CAS Registry Number547-96-6
SMILESNot Available
InChI Identifier
InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChI KeyRIVQQZVHIVNQFH-XJZYBRFWSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as cholesterols and derivatives. Cholesterols and derivatives are compounds containing a 3-hydroxylated cholestane core.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassCholestane steroids
Direct ParentCholesterols and derivatives
Alternative Parents
Substituents
  • Cholesterol-skeleton
  • Cholesterol
  • 7-hydroxysteroid
  • 3-alpha-hydroxysteroid
  • Hydroxysteroid
  • 12-hydroxysteroid
  • 3-hydroxysteroid
  • Cyclic alcohol
  • Secondary alcohol
  • Polyol
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Organooxygen compound
  • Alcohol
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
Ontology
StatusDetected but not Quantified
OriginNot Available
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Cell membrane
  • Cytoplasm
  • Mitochondria
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
Biological Properties
Cellular Locations
  • Cell membrane
  • Cytoplasm
  • Mitochondria
Biospecimen Locations
  • Liver
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
LiverDetected but not QuantifiedNot QuantifiedNot SpecifiedNot Specified
Normal
details
LiverDetected but not QuantifiedNot QuantifiedNot SpecifiedNot Specified
Normal
details
Abnormal Concentrations
Not Available
HMDB IDHMDB0001457
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB022635
KNApSAcK IDNot Available
Chemspider ID141053
KEGG Compound IDC05454
BioCyc IDNot Available
BiGG ID45846
Wikipedia LinkNot Available
METLIN ID6254
PubChem Compound160520
PDB IDNot Available
ChEBI ID16496
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

General function:
Secondary metabolites biosynthesis, transport and catabolism
Specific function:
A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones (PubMed:11412116). Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal (PubMed:11412116). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed:11412116).
Gene Name:
CYP11A1
Uniprot ID:
P00189
Molecular weight:
60333.0
Reactions
5-b-Cholestane-3a ,7a ,12a-triol + 3 NADPH + 3 Oxygen → 27-Deoxy-5b-cyprinol +3 NADP +4 Waterdetails
General function:
Involved in oxidoreductase activity
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
P52898
Molecular weight:
36784.0
Reactions
7a,12a-Dihydroxy-5b-cholestan-3-one + NADP → 5-b-Cholestane-3a ,7a ,12a-triol + NADPHdetails