Showing metabocard for S-Nitrosoglutathione (BMDB0004645)

IdentificationTaxonomyPhysical propertiesPathwaysSpectraConcentrationsLinksReferencesenzymes (1) Show 1 proteinXML
Record Information
Version1.0
Creation Date2016-09-30 23:09:58 UTC
Update Date2020-04-22 15:13:57 UTC
BMDB IDBMDB0004645
Secondary Accession Numbers
  • BMDB04645
Metabolite Identification
Common NameS-Nitrosoglutathione
DescriptionS-Nitrosoglutathione, also known as glutathione thionitrite or GSNO, belongs to the class of organic compounds known as peptides. Peptides are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another. Based on a literature review a significant number of articles have been published on S-Nitrosoglutathione.
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
Glutathione thionitriteChEBI
GSNOChEBI
N-(N-L-gamma-Glutamyl-S-nitroso-L-cysteinyl)glycineChEBI
NitrosoglutathioneChEBI
SNOGChEBI
N-(N-L-g-Glutamyl-S-nitroso-L-cysteinyl)glycineGenerator
N-(N-L-Γ-glutamyl-S-nitroso-L-cysteinyl)glycineGenerator
S-nitroso-GSHMeSH, HMDB
Chemical FormulaC10H16N4O7S
Average Molecular Weight336.322
Monoisotopic Molecular Weight336.073969576
IUPAC Name(2S)-2-amino-4-{[(1R)-1-[(carboxymethyl)carbamoyl]-2-(nitrososulfanyl)ethyl]carbamoyl}butanoic acid
Traditional Namenitrosoglutathione
CAS Registry Number57564-91-7
SMILES
N[C@@H](CCC(=O)N[C@@H](CSN=O)C(=O)NCC(O)=O)C(O)=O
InChI Identifier
InChI=1S/C10H16N4O7S/c11-5(10(19)20)1-2-7(15)13-6(4-22-14-21)9(18)12-3-8(16)17/h5-6H,1-4,11H2,(H,12,18)(H,13,15)(H,16,17)(H,19,20)/t5-,6-/m0/s1
InChI KeyHYHSBSXUHZOYLX-WDSKDSINSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as peptides. Peptides are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentPeptides
Alternative Parents
Substituents
  • Alpha peptide
  • N-acyl-alpha-amino acid
  • N-acyl-alpha amino acid or derivatives
  • Alpha-amino acid
  • Alpha-amino acid or derivatives
  • L-alpha-amino acid
  • Dicarboxylic acid or derivatives
  • Fatty acid
  • Organic s-nitroso compound
  • Amino acid or derivatives
  • Amino acid
  • Nitrosothiol
  • Nitrosothiol-group
  • Organic nitroso compound
  • Carboximidic acid
  • Carboximidic acid derivative
  • Carboxylic acid
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Sulfenyl compound
  • Hydrocarbon derivative
  • Organic oxide
  • Primary aliphatic amine
  • Organopnictogen compound
  • Amine
  • Organic nitrogen compound
  • Organic oxygen compound
  • Carbonyl group
  • Organonitrogen compound
  • Organooxygen compound
  • Organosulfur compound
  • Primary amine
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
StatusExpected but not Quantified
Origin
  • Endogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locationsNot Available
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-3ALOGPS
logP-4.7ChemAxon
logS-2.3ALOGPS
pKa (Strongest Acidic)1.6ChemAxon
pKa (Strongest Basic)9.31ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count9ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area188.25 ŲChemAxon
Rotatable Bond Count11ChemAxon
Refractivity74.48 m³·mol⁻¹ChemAxon
Polarizability30.77 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Biological Properties
Cellular LocationsNot Available
Biospecimen LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
HMDB IDHMDB0004645
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB023390
KNApSAcK IDNot Available
Chemspider ID94647
KEGG Compound IDNot Available
BioCyc IDS-NITROSOGLUTATHIONE
BiGG IDNot Available
Wikipedia LinkS-Nitrosoglutathione
METLIN IDNot Available
PubChem Compound104858
PDB IDNot Available
ChEBI ID50091
References
Synthesis Referenceantoni, Carlo; Bianchi, Maria A.; Beretta, Giuseppe. Stability of nitroso derivatives (nitrosothiols, nitrosophenols, and nitrosohemoglobin) at alkaline pH. Industrie Alimentari (Pinerolo, Italy) (1975), 14(7-8), 79-81.
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

Enzyme Details
1. Carbonyl reductase [NADPH] 1
General function:
Lipid transport and metabolism
Specific function:
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (By similarity).
Gene Name:
CBR1
Uniprot ID:
Q3SZD7
Molecular weight:
30533.0