Showing metabocard for DG(18:1(9Z)/18:1(9Z)/0:0) (BMDB0007218)

IdentificationTaxonomyPhysical propertiesPathwaysSpectraConcentrationsLinksReferencesenzymes (3) Show 3 proteinsXML
Record Information
Version1.0
Creation Date2016-09-30 23:32:56 UTC
Update Date2020-06-04 20:21:04 UTC
BMDB IDBMDB0007218
Secondary Accession Numbers
  • BMDB07218
Metabolite Identification
Common NameDG(18:1(9Z)/18:1(9Z)/0:0)
DescriptionDG(18:1(9Z)/18:1(9Z)/0:0), also known as sn-1,2-dioleoylglycerol or sn-1,2-diolein, belongs to the class of organic compounds known as 1,2-diacylglycerols. These are diacylglycerols containing a glycerol acylated at positions 1 and 2. Thus, DG(18:1(9Z)/18:1(9Z)/0:0) is considered to be a diradylglycerol lipid molecule. DG(18:1(9Z)/18:1(9Z)/0:0) is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. DG(18:1(9Z)/18:1(9Z)/0:0) exists in all living organisms, ranging from bacteria to humans. DG(18:1(9Z)/18:1(9Z)/0:0) participates in a number of enzymatic reactions, within cattle. In particular, CDP-Ethanolamine and DG(18:1(9Z)/18:1(9Z)/0:0) can be converted into cytidine monophosphate and PE(18:1(9Z)/18:1(9Z)) through its interaction with the enzyme choline/ethanolaminephosphotransferase. In addition, CDP-Choline and DG(18:1(9Z)/18:1(9Z)/0:0) can be converted into cytidine monophosphate and PC(18:1(9Z)/18:1(9Z)) through its interaction with the enzyme choline/ethanolaminephosphotransferase. In cattle, DG(18:1(9Z)/18:1(9Z)/0:0) is involved in the metabolic pathway called phosphatidylcholine biosynthesis PC(18:1(9Z)/18:1(9Z)) pathway.
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
1,2-Di-(9Z-octadecenoyl)-sn-glycerolChEBI
DG(18:1/18:1/0:0)ChEBI
sn-1,2-DioleinChEBI
sn-1,2-DioleoylglycerolChEBI
1,2-Dioleoyl-rac-glycerolHMDB
Di-oleoylglycerolHMDB
Glycerol dioleateHMDB
DioleinHMDB
DioleoylglycerolHMDB
1,2-DioleoylglycerolHMDB
Diacylglycerol(36:2)HMDB
DG(18:1/18:1)HMDB
DG(36:2)HMDB
DAG(36:2)HMDB
DiglycerideHMDB
Diacylglycerol(18:1/18:1)HMDB
DiacylglycerolHMDB
DAG(18:1/18:1)HMDB
1,2-Di(9Z-octadecenoyl)-rac-glycerolHMDB
(+--)-1,2-DioleoylglycerolHMDB
1,2-DioleinHMDB
9-Octadecenoic acid (9Z)-, 1-(hydroxymethyl)-1,2-ethanediyl esterHMDB
Glyceryl 1,2-dioleateHMDB
9-Octadecenoic acid (Z)-, 1-(hydroxymethyl)-1,2-ethanediyl esterHMDB
1,2-Glyceryl dioleateHMDB
(+--)-1,2-DioleinHMDB
1,2-Dioleoyl-DL-glycerolHMDB
9-Octadecenoic acid (9Z)-, 1,1'-(1-(hydroxymethyl)-1,2-ethanediyl) esterHMDB
9-Octadecenoic acid (9Z)-, diester with 1,2,3-propanetriolHMDB
Oleic acid diglycerideHMDB
DG(18:1(9Z)/18:1(9Z)/0:0)Lipid Annotator
Chemical FormulaC39H72O5
Average Molecular Weight620.986
Monoisotopic Molecular Weight620.537975414
IUPAC Name(2S)-1-hydroxy-3-[(9Z)-octadec-9-enoyloxy]propan-2-yl (9Z)-octadec-9-enoate
Traditional Name1,2-dioleoyl-sn-glycerol
CAS Registry Number24529-88-2
SMILES
[H][C@](CO)(COC(=O)CCCCCCC\C=C/CCCCCCCC)OC(=O)CCCCCCC\C=C/CCCCCCCC
InChI Identifier
InChI=1S/C39H72O5/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(41)43-36-37(35-40)44-39(42)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,37,40H,3-16,21-36H2,1-2H3/b19-17-,20-18-/t37-/m0/s1
InChI KeyAFSHUZFNMVJNKX-LLWMBOQKSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as 1,2-diacylglycerols. These are diacylglycerols containing a glycerol acylated at positions 1 and 2.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassGlycerolipids
Sub ClassDiradylglycerols
Direct Parent1,2-diacylglycerols
Alternative Parents
Substituents
  • 1,2-acyl-sn-glycerol
  • Fatty acid ester
  • Fatty acyl
  • Dicarboxylic acid or derivatives
  • Carboxylic acid ester
  • Carboxylic acid derivative
  • Organic oxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Primary alcohol
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
StatusDetected and Quantified
Origin
  • Endogenous
  • Exogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Cell membrane
  • Membrane
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP10.26ALOGPS
logP13.06ChemAxon
logS-7.7ALOGPS
pKa (Strongest Acidic)14.58ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area72.83 ŲChemAxon
Rotatable Bond Count36ChemAxon
Refractivity188.34 m³·mol⁻¹ChemAxon
Polarizability80.99 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Biological Properties
Cellular Locations
  • Cell membrane
  • Membrane
Biospecimen Locations
  • All Tissues
  • Milk
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
All TissuesExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
 details
MilkDetected and Quantified25 +/- 2 uMNot SpecifiedNot Specified
Normal		 details
MilkDetected and Quantified55 +/- 4 uMNot SpecifiedNot Specified
Normal		 details
MilkDetected and Quantified118 +/- 3 uMNot SpecifiedNot Specified
Normal		 details
MilkDetected and Quantified2.6 +/- 0.1 uMNot SpecifiedNot Specified
Normal		 details
Abnormal Concentrations
Not Available
HMDB IDHMDB0007218
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB094043
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound9543716
PDB IDNot Available
ChEBI ID52333
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. A. Foroutan et al. (2019). A. Foroutan et al. The Chemical Composition of Commercial Cow's Milk (in preparation). Journal of Agricultural and Food Chemistry.

Enzymes

Enzyme Details
1. Ethanolaminephosphotransferase 1
General function:
Involved in ethanolaminephosphotransferase activity
Specific function:
Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the foramtion of phosphatidylethanolamine via 'Kennedy' pathway (By similarity).
Gene Name:
SELENOI
Uniprot ID:
Q17QM4
Molecular weight:
45214.0
Reactions
CDP-Ethanolamine + DG(18:1(9Z)/18:1(9Z)/0:0) → Cytidine monophosphate + PE(18:1(9Z)/18:1(9Z))details
Enzyme Details
2. Lipin 1
General function:
Not Available
Specific function:
Not Available
Gene Name:
LPIN1
Uniprot ID:
E1BPE8
Molecular weight:
102857.0
Reactions
PA(18:1(9Z)/18:1(9Z)) + Water → DG(18:1(9Z)/18:1(9Z)/0:0) + Hydrogen phosphatedetails
Enzyme Details
3. Diacylglycerol O-acyltransferase 1
General function:
Not Available
Specific function:
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. In liver, plays a role in esterifying exogenous fatty acids to glycerol.
Gene Name:
DGAT1
Uniprot ID:
Q8MK44
Molecular weight:
55602.0
Reactions
DG(18:1(9Z)/18:1(9Z)/0:0) + Oleoyl-CoA → TG(18:1(9Z)/18:1(9Z)/18:1(9Z))[iso] + Coenzyme Adetails
DG(18:1(9Z)/18:1(9Z)/0:0) + Gamma-linolenoyl-CoA → TG(18:1(9Z)/18:1(9Z)/18:3(6Z,9Z,12Z))[iso3] + Coenzyme Adetails
DG(18:1(9Z)/18:1(9Z)/0:0) + Eicosanoyl-CoA → TG(18:1(9Z)/18:1(9Z)/20:0) + Coenzyme Adetails
DG(18:1(9Z)/18:1(9Z)/0:0) + Gondoyl-CoA → TG(18:1(9Z)/18:1(9Z)/20:1(11Z)) + Coenzyme Adetails
DG(18:1(9Z)/18:1(9Z)/0:0) + 5Z,8Z,11Z,14Z-eicosatetraenonyl-CoA → TG(18:1(9Z)/18:1(9Z)/20:4(5Z,8Z,11Z,14Z)) + Coenzyme Adetails
DG(18:1(9Z)/18:1(9Z)/0:0) + Docosanoyl-CoA → TG(18:1(9Z)/18:1(9Z)/22:0) + Coenzyme Adetails
DG(18:1(9Z)/18:1(9Z)/0:0) + Erucoyl-CoA → TG(18:1(9Z)/18:1(9Z)/22:1(13Z)) + Coenzyme Adetails
DG(18:1(9Z)/18:1(9Z)/0:0) + Clupanodonyl CoA → TG(18:1(9Z)/18:1(9Z)/22:5(7Z,10Z,13Z,16Z,19Z)) + Coenzyme Adetails