Showing metabocard for DG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/0:0) (BMDB0007278)

IdentificationTaxonomyPhysical propertiesPathwaysSpectraConcentrationsLinksReferencesenzymes (2) Show 2 proteinsXML
Record Information
Version1.0
Creation Date2016-09-30 23:34:08 UTC
Update Date2020-05-21 16:27:54 UTC
BMDB IDBMDB0007278
Secondary Accession Numbers
  • BMDB07278
Metabolite Identification
Common NameDG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/0:0)
DescriptionDG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/0:0), also known as dg(18:3(6z,9z,12z)/18:3(6z,9z,12z)/0:0) or DAG(18:3/18:3), belongs to the class of organic compounds known as lineolic acids and derivatives. These are derivatives of lineolic acid. Lineolic acid is a polyunsaturated omega-6 18 carbon long fatty acid, with two CC double bonds at the 9- and 12-positions. Thus, DG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/0:0) is considered to be a diradylglycerol lipid molecule. DG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/0:0) is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. DG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/0:0) participates in a number of enzymatic reactions, within cattle. In particular, DG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/0:0) can be biosynthesized from PA(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)); which is catalyzed by the enzyme phosphatidate phosphatase. In addition, DG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/0:0) and eicosanoyl-CoA can be converted into TG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/20:0) through its interaction with the enzyme dg(18:3(6z,9z,12z)/18:3(6z,9z,12z)/0:0) O-acyltransferase. In cattle, DG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/0:0) is involved in the metabolic pathway called de novo triacylglycerol biosynthesis TG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/20:0) pathway.
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
1,2-Dig-linolenoyl-rac-glycerolHMDB
DAG(18:3/18:3)HMDB
DAG(18:3N6/18:3N6)HMDB
DAG(18:3W6/18:3W6)HMDB
DAG(36:6)HMDB
DG(18:3/18:3)HMDB
DG(18:3N6/18:3N6)HMDB
DG(18:3W6/18:3W6)HMDB
DG(36:6)HMDB
DiacylglycerolHMDB
Diacylglycerol(18:3/18:3)HMDB
Diacylglycerol(18:3n6/18:3n6)HMDB
Diacylglycerol(18:3W6/18:3W6)HMDB
Diacylglycerol(36:6)HMDB
DiglycerideHMDB
1,2-Di(6Z,9Z,12Z-octadecatrienoyl)-rac-glycerolHMDB
DG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/0:0)Lipid Annotator
Chemical FormulaC39H64O5
Average Molecular Weight612.9225
Monoisotopic Molecular Weight612.475375158
IUPAC Name(2S)-1-hydroxy-3-[(6Z,9Z,12Z)-octadeca-6,9,12-trienoyloxy]propan-2-yl (6Z,9Z,12Z)-octadeca-6,9,12-trienoate
Traditional Namediacylglycerol
CAS Registry NumberNot Available
SMILES
[H][C@](CO)(COC(=O)CCCC\C=C/C\C=C/C\C=C/CCCCC)OC(=O)CCCC\C=C/C\C=C/C\C=C/CCCCC
InChI Identifier
InChI=1S/C39H64O5/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(41)43-36-37(35-40)44-39(42)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h11-14,17-20,23-26,37,40H,3-10,15-16,21-22,27-36H2,1-2H3/b13-11-,14-12-,19-17-,20-18-,25-23-,26-24-/t37-/m0/s1
InChI KeyJVRVKOOOXHGJKI-ITLZUPGPSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as lineolic acids and derivatives. These are derivatives of lineolic acid. Lineolic acid is a polyunsaturated omega-6 18 carbon long fatty acid, with two CC double bonds at the 9- and 12-positions.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassFatty Acyls
Sub ClassLineolic acids and derivatives
Direct ParentLineolic acids and derivatives
Alternative Parents
Substituents
  • Octadecanoid
  • 1,2-acyl-sn-glycerol
  • Diacylglycerol
  • Diradylglycerol
  • Fatty acid ester
  • Glycerolipid
  • Dicarboxylic acid or derivatives
  • Carboxylic acid ester
  • Carboxylic acid derivative
  • Organooxygen compound
  • Hydrocarbon derivative
  • Organic oxygen compound
  • Organic oxide
  • Carbonyl group
  • Primary alcohol
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
StatusExpected but not Quantified
Origin
  • Endogenous
  • Exogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Cell membrane
  • Cytoplasm
  • Membrane
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP8.66ALOGPS
logP11.61ChemAxon
logS-7.5ALOGPS
pKa (Strongest Acidic)14.58ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area72.83 ŲChemAxon
Rotatable Bond Count32ChemAxon
Refractivity192.8 m³·mol⁻¹ChemAxon
Polarizability75.21 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (1 TMS) - 70eV, Positivesplash10-0pb9-4441925000-34bef546be5403c0a1b8View in MoNA
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (TBDMS_1_1) - 70eV, PositiveNot AvailableView in JSpectraViewer
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS ("DG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/0:0),1TMS,#1" TMS) - 70eV, PositiveNot AvailableView in JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-001i-0000009000-41ed6867d946c515aebaView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000j-0009063000-eb118cf31368548bb613View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0019-0009017000-bc3dc31d30d265eb8193View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000i-0000009000-615a30fbd964efd1b181View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000i-0000009000-615a30fbd964efd1b181View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0a4i-0009001000-62ec07d30004c0618e17View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-001i-0000009000-3d8ea9f544e62fbb777cView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000j-0009063000-9db91debbfc4b8664107View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0019-0009017000-b2a533b5e34d2ddc2b78View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-03di-6344296000-886e61b0fbc8c1e73432View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-03dr-5297130000-0577a3cf61397fa6352fView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0imr-2394000000-9543a744537e207d2c7dView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-03fr-2065009000-8587ef13aa98ec94d2ffView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-056r-5094000000-d94fbd738b32312247e4View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-2090000000-cd1a7a55f501dc4f231eView in MoNA
Biological Properties
Cellular Locations
  • Cell membrane
  • Cytoplasm
  • Membrane
Biospecimen Locations
  • All Tissues
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
All TissuesExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
 details
Abnormal Concentrations
Not Available
HMDB IDHMDB0007278
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB024471
KNApSAcK IDNot Available
Chemspider ID24766028
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound14275411
PDB IDNot Available
ChEBI IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

Enzyme Details
1. Ethanolaminephosphotransferase 1
General function:
Involved in ethanolaminephosphotransferase activity
Specific function:
Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the foramtion of phosphatidylethanolamine via 'Kennedy' pathway (By similarity).
Gene Name:
SELENOI
Uniprot ID:
Q17QM4
Molecular weight:
45214.0
Reactions
CDP-Ethanolamine + DG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/0:0) → Cytidine monophosphate + PE(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z))details
Enzyme Details
2. Diacylglycerol O-acyltransferase 1
General function:
Not Available
Specific function:
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. In liver, plays a role in esterifying exogenous fatty acids to glycerol.
Gene Name:
DGAT1
Uniprot ID:
Q8MK44
Molecular weight:
55602.0
Reactions
DG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/0:0) + Gamma-linolenoyl-CoA → TG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)) + Coenzyme Adetails
DG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/0:0) + Eicosanoyl-CoA → TG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/20:0)[iso3] + Coenzyme Adetails
DG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/0:0) + Gondoyl-CoA → TG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/20:1(11Z)) + Coenzyme Adetails
DG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/0:0) + 5Z,8Z,11Z,14Z-eicosatetraenonyl-CoA → TG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/20:4(5Z,8Z,11Z,14Z)) + Coenzyme Adetails
DG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/0:0) + Docosanoyl-CoA → TG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/22:0) + Coenzyme Adetails
DG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/0:0) + Erucoyl-CoA → TG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/22:1(13Z)) + Coenzyme Adetails
DG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/0:0) + Clupanodonyl CoA → TG(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)/22:5(7Z,10Z,13Z,16Z,19Z)) + Coenzyme Adetails