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Record Information
Version1.0
Creation Date2016-10-03 17:41:28 UTC
Update Date2020-05-21 16:26:44 UTC
BMDB IDBMDB0009377
Secondary Accession Numbers
  • BMDB09377
Metabolite Identification
Common NamePE(20:3(8Z,11Z,14Z)/24:1(15Z))
DescriptionPE(20:3(8Z,11Z,14Z)/24:1(15Z)), also known as GPEtn(20:3/24:1) or GPEtn(44:4), belongs to the class of organic compounds known as phosphatidylethanolamines. These are glycerophosphoetahnolamines in which two fatty acids are bonded to the glycerol moiety through ester linkages. PE(20:3(8Z,11Z,14Z)/24:1(15Z)) is possibly soluble (in water) and a very strong basic compound (based on its pKa). PE(20:3(8Z,11Z,14Z)/24:1(15Z)) participates in a number of enzymatic reactions, within cattle. In particular, PE(20:3(8Z,11Z,14Z)/24:1(15Z)) can be biosynthesized from PS(20:3(8Z,11Z,14Z)/24:1(15Z)) through the action of the enzyme phosphatidylserine decarboxylase. Furthermore, Cytidine monophosphate and PE(20:3(8Z,11Z,14Z)/24:1(15Z)) can be biosynthesized from CDP-ethanolamine and DG(20:3(8Z,11Z,14Z)/24:1(15Z)/0:0) through the action of the enzyme choline/ethanolaminephosphotransferase. Furthermore, Cytidine monophosphate and PE(20:3(8Z,11Z,14Z)/24:1(15Z)) can be biosynthesized from CDP-ethanolamine and DG(20:3(8Z,11Z,14Z)/24:1(15Z)/0:0); which is mediated by the enzyme choline/ethanolaminephosphotransferase. Finally, PE(20:3(8Z,11Z,14Z)/24:1(15Z)) can be biosynthesized from PS(20:3(8Z,11Z,14Z)/24:1(15Z)) through the action of the enzyme phosphatidylserine decarboxylase. In cattle, PE(20:3(8Z,11Z,14Z)/24:1(15Z)) is involved in a couple of metabolic pathways, which include phosphatidylethanolamine biosynthesis pe(20:3(8Z,11Z,14Z)/24:1(15Z)) pathway and phosphatidylcholine biosynthesis PC(20:3(8Z,11Z,14Z)/24:1(15Z)) pathway.
Structure
Thumb
Synonyms
ValueSource
1-Homo-g-linolenoyl-2-nervonoyl-sn-glycero-3-phosphoethanolamineHMDB
1-Homo-gamma-linolenoyl-2-nervonoyl-sn-glycero-3-phosphoethanolamineHMDB
GPEtn(20:3/24:1)HMDB
GPEtn(20:3n6/24:1n9)HMDB
GPEtn(20:3W6/24:1W9)HMDB
GPEtn(44:4)HMDB
PE(20:3/24:1)HMDB
PE(20:3N6/24:1N9)HMDB
PE(20:3W6/24:1W9)HMDB
PE(44:4)HMDB
Phophatidylethanolamine(20:3/24:1)HMDB
Phophatidylethanolamine(20:3n6/24:1n9)HMDB
Phophatidylethanolamine(20:3W6/24:1W9)HMDB
Phophatidylethanolamine(44:4)HMDB
1-(8Z,11Z,14Z-Eicosatrienoyl)-2-(15Z-tetracosanoyl)-sn-glycero-3-phosphoethanolamineHMDB
PE(20:3(8Z,11Z,14Z)/24:1(15Z))Lipid Annotator
Chemical FormulaC49H90NO8P
Average Molecular Weight852.2146
Monoisotopic Molecular Weight851.640405373
IUPAC Name(2-aminoethoxy)[(2R)-3-[(8Z,11Z,14Z)-icosa-8,11,14-trienoyloxy]-2-[(15Z)-tetracos-15-enoyloxy]propoxy]phosphinic acid
Traditional Name2-aminoethoxy(2R)-3-[(8Z,11Z,14Z)-icosa-8,11,14-trienoyloxy]-2-[(15Z)-tetracos-15-enoyloxy]propoxyphosphinic acid
CAS Registry NumberNot Available
SMILES
[H][C@@](COC(=O)CCCCCC\C=C/C\C=C/C\C=C/CCCCC)(COP(O)(=O)OCCN)OC(=O)CCCCCCCCCCCCC\C=C/CCCCCCCC
InChI Identifier
InChI=1S/C49H90NO8P/c1-3-5-7-9-11-13-15-17-19-21-22-23-24-26-28-30-32-34-36-38-40-42-49(52)58-47(46-57-59(53,54)56-44-43-50)45-55-48(51)41-39-37-35-33-31-29-27-25-20-18-16-14-12-10-8-6-4-2/h12,14,17-20,27,29,47H,3-11,13,15-16,21-26,28,30-46,50H2,1-2H3,(H,53,54)/b14-12-,19-17-,20-18-,29-27-/t47-/m1/s1
InChI KeyGUMSBNXGPBAONF-UBRVPYPMSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as phosphatidylethanolamines. These are glycerophosphoetahnolamines in which two fatty acids are bonded to the glycerol moiety through ester linkages.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassGlycerophospholipids
Sub ClassGlycerophosphoethanolamines
Direct ParentPhosphatidylethanolamines
Alternative Parents
Substituents
  • Diacylglycero-3-phosphoethanolamine
  • Phosphoethanolamine
  • Fatty acid ester
  • Dialkyl phosphate
  • Dicarboxylic acid or derivatives
  • Organic phosphoric acid derivative
  • Phosphoric acid ester
  • Alkyl phosphate
  • Fatty acyl
  • Amino acid or derivatives
  • Carboxylic acid ester
  • Carboxylic acid derivative
  • Organopnictogen compound
  • Organic oxygen compound
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Primary aliphatic amine
  • Organic nitrogen compound
  • Primary amine
  • Carbonyl group
  • Organic oxide
  • Hydrocarbon derivative
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External DescriptorsNot Available
Ontology
StatusExpected but not Quantified
Origin
  • Endogenous
  • Exogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Cell membrane
  • Intracellular membrane
  • Membrane
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP9.72ALOGPS
logP14.34ChemAxon
logS-7.3ALOGPS
pKa (Strongest Acidic)1.87ChemAxon
pKa (Strongest Basic)10ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area134.38 ŲChemAxon
Rotatable Bond Count47ChemAxon
Refractivity250.68 m³·mol⁻¹ChemAxon
Polarizability104.98 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0udi-0003000090-dba18fb706269cb4500cView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0udi-0003000090-dba18fb706269cb4500cView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-15mi-0109020030-bac6845f5480c2df028eView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0udi-0000000190-51f14322a8d5057e2e4cView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0ik9-0001340970-79ffe2cec68fcbb4a5e3View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-03di-0001340930-739d6ec54b8fdee0f02cView in MoNA
Biological Properties
Cellular Locations
  • Cell membrane
  • Intracellular membrane
  • Membrane
Biospecimen Locations
  • All Tissues
  • Brain
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
All TissuesExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
details
BrainExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
details
Abnormal Concentrations
Not Available
HMDB IDHMDB0009377
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB026567
KNApSAcK IDNot Available
Chemspider ID24768828
KEGG Compound IDC00350
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound53479782
PDB IDNot Available
ChEBI IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

General function:
Involved in ethanolaminephosphotransferase activity
Specific function:
Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the foramtion of phosphatidylethanolamine via 'Kennedy' pathway (By similarity).
Gene Name:
SELENOI
Uniprot ID:
Q17QM4
Molecular weight:
45214.0
Reactions
CDP-Ethanolamine + DG(20:3(8Z,11Z,14Z)/24:1(15Z)/0:0) → Cytidine monophosphate + PE(20:3(8Z,11Z,14Z)/24:1(15Z))details