Showing Protein Acyl-CoA 6-desaturase (BMDBP00001)
| Identification | |||||
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| BMDB Protein ID | BMDBP00001 | ||||
| Secondary Accession Numbers | None | ||||
| Name | Acyl-CoA 6-desaturase | ||||
| Synonyms | Not Available | ||||
| Gene Name | FADS2 | ||||
| Protein Type | Enzyme | ||||
| Biological Properties | |||||
| General Function | Lipid transport and metabolism | ||||
| Specific Function | Acts as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (By similarity). Subsequently, in the biosynthetic pathway of HUFA n-3 series, desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). Desaturates palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum (By similarity). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity). | ||||
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| GO Classification | Not Available | ||||
| Cellular Location | Not Available | ||||
| Gene Properties | |||||
| Chromosome Location | 29 | ||||
| Locus | Not Available | ||||
| SNPs | FADS2 | ||||
| Gene Sequence |
>1335 bp ATGGGGAAGGGGGGAAACCAGGACGAGGGGGCCACCGAGCTTGAGGCGCCGATGCCTACC TTCCGCTGGGAGGAGATTCAGAAGCACAACCTGCGCACCGACAAGTGGCTGGTCATCGAT CGCAAGGTCTACAACATCACTAAATGGTCCAGCCGGCACCCCGGGGGCCAGCGGGTCATC GGGCACTATGCCGGGGAAGATGCTACGGACGCCTTCCTGGCCTTCCACCGCAACCTTGAT TTTGTGCGCAAGTTCATGAAGCCCCTGTTAATTGGCGAGCTGGCCCCTGAGGAGCCCAGC CAGGACCGCGGCAAGAATTCCCAGATCACCGAGGACTTCCGGGCCCTGAGGAAGACCGCT GAGGACATGAACCTGTTCAAGAGTAACCAGCTCTTCTTCCTTCTCCACCTGGCCCACATC ATCGCCATGGAGAGCATCGCCTGGTTCACTCTCTTCTACTTTGGCAACGGCTGGATTCCA ACCATCATTACGGCCTTCGTCCTTGCTACCTCTCAGGCCCAGGCTGGATGGCTGCAACAC GATTACGGCCACCTCTCTGTTTACAAGAAGTCCATGTGGAACCACATCGTCCACAAGTTC GTCATCGGTCACTTAAAGGGTGCCTCTGCCAACTGGTGGAACCATCGCCACTTCCAGCAC CATGCCAAACCCAACATCTTCCACAAGGATCCAGATGTGAACATGCTGCACGTGTTTGTC CTGGGCGAGTGGCAGCCCATTGAGTACGGCAAGAAGAAGCTGAAATACCTGCCTTACAAC CACCAGCATGAGTACTTCTTCCTGATCGGGCCGCCGCTGCTCATCCCTTTGTATTTCCAG TACCAGATCATCATGACCATGATCGTTCGCAAGTACTGGGCGGACTTGGCCTGGGCCATC AGCTACTACACCCGTTTCTTCATCACCTACATCCCTTTCTATGGTGTTCTGGGATCCATC CTTTTCCTCAACTTCATCAGGTTCCTGGAGAGCCACTGGTTTGTGTGGGTCACACAGATG AATCACATCGTCATGGAGATTGACCGAGAGCCCTACCGTGACTGGTTCAGCAGCCAGCTG GCAGCCACCTGCAATGTGGAGCAGTCCTTCTTCAATGACTGGTTCAGTGGGCACCTCAAC TTCCAGATCGAGCACCACCTTTTCCCCACCATGCCCCGGCACAACCTGCACAAGATCGCC CCCCTGGTGAGGTCCCTGTGCGCCAAGCACGGCATTGAGTACCAGGAGAAGCCGCTGCTC CGGGCCCTGCAAGACATCATCGGGTCCCTGAGGAAGTCTGGGCAGCTGTGGCTGGACGCC TACCTCCACAAATGA |
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| Protein Properties | |||||
| Number of Residues | 444 | ||||
| Molecular Weight | 52533.0 | ||||
| Theoretical pI | 9.31 | ||||
| Pfam Domain Function | Not Available | ||||
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Fatty acid desaturase 2 MGKGGNQDEGATELEAPMPTFRWEEIQKHNLRTDKWLVIDRKVYNITKWSSRHPGGQRVI GHYAGEDATDAFLAFHRNLDFVRKFMKPLLIGELAPEEPSQDRGKNSQITEDFRALRKTA EDMNLFKSNQLFFLLHLAHIIAMESIAWFTLFYFGNGWIPTIITAFVLATSQAQAGWLQH DYGHLSVYKKSMWNHIVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDVNMLHVFV LGEWQPIEYGKKKLKYLPYNHQHEYFFLIGPPLLIPLYFQYQIIMTMIVRKYWADLAWAI SYYTRFFITYIPFYGVLGSILFLNFIRFLESHWFVWVTQMNHIVMEIDREPYRDWFSSQL AATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIAPLVRSLCAKHGIEYQEKPLL RALQDIIGSLRKSGQLWLDAYLHK |
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| External Links | |||||
| GenBank ID Protein | AAI23736.1 | ||||
| UniProtKB/Swiss-Prot ID | A4FV48 | ||||
| UniProtKB/Swiss-Prot Entry Name | FADS2_BOVIN | ||||
| PDB IDs | Not Available | ||||
| GenBank Gene ID | BC123735 | ||||
| GeneCard ID | FADS2 | ||||
| GenAtlas ID | Not Available | ||||
| HGNC ID | Not Available | ||||
| References | |||||
| General References | Not Available | ||||