| Identification |
|---|
| BMDB Protein ID
| BMDBP00001 |
| Secondary Accession Numbers
| None |
| Name
| Acyl-CoA 6-desaturase |
| Synonyms
|
Not Available
|
| Gene Name
| FADS2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Acts as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (By similarity). Subsequently, in the biosynthetic pathway of HUFA n-3 series, desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). Desaturates palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum (By similarity). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity). |
| Pathways
|
- Alpha Linolenic Acid and Linoleic Acid Metabolism
- Lipid metabolism
- Polyunsaturated fatty acid biosynthesis
|
| Reactions
|
| Linoleic acid → Gamma-Linolenic acid |
details
|
| 8,11,14-Eicosatrienoic acid → Arachidonic acid |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 29 |
| Locus
| Not Available |
| SNPs
| FADS2 |
| Gene Sequence
|
>1335 bp
ATGGGGAAGGGGGGAAACCAGGACGAGGGGGCCACCGAGCTTGAGGCGCCGATGCCTACC
TTCCGCTGGGAGGAGATTCAGAAGCACAACCTGCGCACCGACAAGTGGCTGGTCATCGAT
CGCAAGGTCTACAACATCACTAAATGGTCCAGCCGGCACCCCGGGGGCCAGCGGGTCATC
GGGCACTATGCCGGGGAAGATGCTACGGACGCCTTCCTGGCCTTCCACCGCAACCTTGAT
TTTGTGCGCAAGTTCATGAAGCCCCTGTTAATTGGCGAGCTGGCCCCTGAGGAGCCCAGC
CAGGACCGCGGCAAGAATTCCCAGATCACCGAGGACTTCCGGGCCCTGAGGAAGACCGCT
GAGGACATGAACCTGTTCAAGAGTAACCAGCTCTTCTTCCTTCTCCACCTGGCCCACATC
ATCGCCATGGAGAGCATCGCCTGGTTCACTCTCTTCTACTTTGGCAACGGCTGGATTCCA
ACCATCATTACGGCCTTCGTCCTTGCTACCTCTCAGGCCCAGGCTGGATGGCTGCAACAC
GATTACGGCCACCTCTCTGTTTACAAGAAGTCCATGTGGAACCACATCGTCCACAAGTTC
GTCATCGGTCACTTAAAGGGTGCCTCTGCCAACTGGTGGAACCATCGCCACTTCCAGCAC
CATGCCAAACCCAACATCTTCCACAAGGATCCAGATGTGAACATGCTGCACGTGTTTGTC
CTGGGCGAGTGGCAGCCCATTGAGTACGGCAAGAAGAAGCTGAAATACCTGCCTTACAAC
CACCAGCATGAGTACTTCTTCCTGATCGGGCCGCCGCTGCTCATCCCTTTGTATTTCCAG
TACCAGATCATCATGACCATGATCGTTCGCAAGTACTGGGCGGACTTGGCCTGGGCCATC
AGCTACTACACCCGTTTCTTCATCACCTACATCCCTTTCTATGGTGTTCTGGGATCCATC
CTTTTCCTCAACTTCATCAGGTTCCTGGAGAGCCACTGGTTTGTGTGGGTCACACAGATG
AATCACATCGTCATGGAGATTGACCGAGAGCCCTACCGTGACTGGTTCAGCAGCCAGCTG
GCAGCCACCTGCAATGTGGAGCAGTCCTTCTTCAATGACTGGTTCAGTGGGCACCTCAAC
TTCCAGATCGAGCACCACCTTTTCCCCACCATGCCCCGGCACAACCTGCACAAGATCGCC
CCCCTGGTGAGGTCCCTGTGCGCCAAGCACGGCATTGAGTACCAGGAGAAGCCGCTGCTC
CGGGCCCTGCAAGACATCATCGGGTCCCTGAGGAAGTCTGGGCAGCTGTGGCTGGACGCC
TACCTCCACAAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 444 |
| Molecular Weight
| 52533.0 |
| Theoretical pI
| 9.31 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 123-143
- 148-168
- 265-285
- 306-326
|
| Protein Sequence
|
>Fatty acid desaturase 2
MGKGGNQDEGATELEAPMPTFRWEEIQKHNLRTDKWLVIDRKVYNITKWSSRHPGGQRVI
GHYAGEDATDAFLAFHRNLDFVRKFMKPLLIGELAPEEPSQDRGKNSQITEDFRALRKTA
EDMNLFKSNQLFFLLHLAHIIAMESIAWFTLFYFGNGWIPTIITAFVLATSQAQAGWLQH
DYGHLSVYKKSMWNHIVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDVNMLHVFV
LGEWQPIEYGKKKLKYLPYNHQHEYFFLIGPPLLIPLYFQYQIIMTMIVRKYWADLAWAI
SYYTRFFITYIPFYGVLGSILFLNFIRFLESHWFVWVTQMNHIVMEIDREPYRDWFSSQL
AATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIAPLVRSLCAKHGIEYQEKPLL
RALQDIIGSLRKSGQLWLDAYLHK
|
| External Links |
|---|
| GenBank ID Protein
| AAI23736.1 |
| UniProtKB/Swiss-Prot ID
| A4FV48 |
| UniProtKB/Swiss-Prot Entry Name
| FADS2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC123735 |
| GeneCard ID
| FADS2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
