| Identification |
|---|
| BMDB Protein ID
| BMDBP00022 |
| Secondary Accession Numbers
| None |
| Name
| Nitric oxide synthase, endothelial |
| Synonyms
|
Not Available
|
| Gene Name
| NOS3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Inorganic ion transport and metabolism |
| Specific Function
| Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. |
| Pathways
|
- Arginine and Proline Metabolism
- Ion Channels and Their Functional Role in Vascular Endothelium
- Nitric Oxide Signaling Pathway
- Succinate Signalling During Inflammation
|
| Reactions
|
| 2 L-Arginine + 3 NADPH + 4 Oxygen →2 N-(o)-Hydroxyarginine +2 Nitric oxide +3 NADP +4 Water |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| Not Available |
| SNPs
| NOS3 |
| Gene Sequence
|
>3618 bp
ATGGGCAACTTGAAGAGTGTGGGCCAGGAGCCCGGGCCCCCCTGCGGCCTGGGGCTGGGG
CTGGGCCTCGGGCTATGCGGCAAGCAGGGCCCAGCCTCCCCGGCACCTGAGCCCAGCCGG
GCCCCCGCACCCGCCACCCCGCACGCGCCAGACCACAGCCCAGCTCCCAACAGCCCCACG
CTGACCCGGCCTCCGGAGGGGCCCAAGTTCCCTCGCGTGAAGAACTGGGAGCTGGGGAGC
ATCACCTACGACACTCTGTGCGCGCAGTCCCAACAGGACGGGCCCTGCACTCCCAGGTGC
TGCCTGGGCTCCCTGGTGTTGCCCCGGAAACTGCAGACCCGGCCCTCCCCGGGACCTCCA
CCCGCTGAGCAGCTGCTGAGCCAGGCCAGGGACTTCATCAACCAGTACTACAGCTCCATC
AAGAGGAGCGGCTCCCAGGCTCACGAGGAGCGGCTTCAGGAGGTGGAGGCCGAGGTGGCA
TCCACGGGCACCTACCACCTCCGAGAGAGCGAGCTGGTGTTCGGGGCCAAGCAGGCCTGG
CGCAACGCACCCCGCTGCGTGGGCCGCATCCAGTGGGGGAAGCTGCAGGTGTTTGATGCC
CGGGACTGCAGCTCAGCACAGGAGATGTTCACCTACATCTGCAACCACATCAAGTACGCC
ACCAACCGCGGCAACCTTCGCTCGGCCATCACAGTGTTCCCGCAGCGCGCCCCGGGCCGC
GGAGACTTCCGGATCTGGAACAGCCAGCTGGTGCGCTACGCAGGCTACAGACAGCAGGAT
GGCTCTGTGCGTGGGGACCCAGCCAATGTGGAGATCACGGAGCTCTGCATCCAGCACGGC
TGGACCCCCGGAAACGGCCGCTTCGACGTGCTGCCCCTGCTGCTCCAGGCCCCAGACGAG
GCTCCAGAGCTCTTTGTTCTGCCCCCCGAGCTGGTCCTTGAAGTGCCCCTGGAGCACCCC
ACACTGGAGTGGTTCGCGGCCCTGGGCCTGCGATGGTATGCCCTCCCGGCCGTGTCCAAC
ATGCTGCTGGAAATCGGGGGTCTGGAGTTCTCCGCGGCCCCCTTCAGCGGCTGGTACATG
AGCACGGAGATTGGCACGCGGAACCTGTGTGACCCTCACCGCTACAATATCCTGGAGGAT
GTGGCCGTCTGCATGGACCTCGACACGCGGACCACCTCGTCCCTGTGGAAGGACAAGGCG
GCCGTGGAGATCAACCTGGCTGTGCTGCACAGCTTTCAGCTCGCCAAGGTGACCATCGTG
GACCACCACGCCGCCACGGTGTCCTTCATGAAGCACCTGGACAACGAGCAGAAGGCCAGG
GGGGGCTGCCCCGCCGACTGGGCCTGGATCGTGCCCCCCATCTCAGGCAGCCTCACGCCC
GTCTTCCACCAGGAGATGGTCAACTACATCCTGTCCCCTGCCTTCCGCTACCAGCCAGAC
CCCTGGAAAGGGAGCGCGACCAAGGGCGCAGGCATCACCAGGAAGAAGACCTTTAAGGAA
GTGGCCAACGCGGTGAAGATCTCTGCCTCACTCATGGGCACCCTGATGGCCAAGCGAGTG
AAAGCAACCATCCTGTACGCCTCTGAGACCGGCCGGGCCCAGAGCTACGCTCAGCAGCTG
GGGAGGCTCTTCCGGAAGGCCTTCGATCCCCGGGTCCTGTGCATGGATGAGTATGACGTG
GTGTCCCTGGAGCACGAGGCGCTGGTACTGGTGGTGACCAGCACCTTTGGGAATGGCGAT
CCCCCGGAGAATGGAGAGAGTTTTGCAGCTGCCCTGATGGAGATGTCGGGGCCCTACAAC
AGCTCCCCGCGGCCGGAACAGCACAAGAGTTACAAGATCCGCTTCAACAGCGTCTCCTGC
TCAGACCCGCTGGTGTCCTCCTGGCGGCGGAAGAGAAAGGAGTCCAGCAACACAGACAGT
GCGGGGGCCCTGGGGACCCTCAGGTTCTGTGTGTTCGGACTGGGCTCCCGGGCATACCCC
CACTTCTGCGCCTTCGCGCGAGCGGTGGACACCCGGCTGGAAGAGCTTGGAGGGGAGCGG
CTGCTGCAGCTGGGCCAGGGCGATGAGCTCTGCGGCCAGGAAGAGGCCTTCCGTGGTTGG
GCAAAGGCGGCCTTCCAGGCCTCCTGTGAGACCTTCTGCGTTGGGGAGGAGGCCAAGGCC
GCCGCCCAGGACATCTTCAGCCCCAAACGGAGCTGGAAACGCCAGAGGTACCGGCTGAGC
ACCCAGGCCGAGGGCCTCCAGCTGCTGCCAGGCCTGATCCACGTGCACAGACGGAAGATG
TTTCAGGCCACAGTCCTCTCGGTGGAAAATCTGCAAAGCAGCAAGTCCACCCGGGCCACC
ATCCTGGTGCGCCTGGACACTGCAGGCCAGGAGGGGCTGCAGTACCAGCCGGGGGACCAC
ATAGGCATCTGCCCGCCCAACCGGCCGGGCCTGGTGGAGGCGCTGCTGAGCCGCGTGGAG
GACCCGCCACCGCCCACCGAGTCTGTGGCTGTGGAGCAGCTGGAGAAAGGCAGCCCAGGC
GGCCCTCCTCCCAGCTGGGTGCGGGACCCACGGCTGCCCCCGTGCACGCTGCGCCAGGCT
CTCACCTTCTTCCTGGACATCACCTCCCCACCCAGCCCCCGGCTTCTCCGACTGCTCAGC
ACCCTGGCCGAAGAACCCAGCGAGCAGCAGGAGCTTGAGACCCTCAGTCAGGACCCCCGG
CGCTACGAGGAGTGGAAGTGGTTCCGCTGCCCCACGCTGCTGGAGGTGCTGGAGCAGTTC
CCGTCCGTGGCGCTGCCCGCCCCGCTGCTCCTCACCCAGCTGCCCCTGCTGCAGCCCCGG
TACTACTCTGTCAGCTCGGCCCCCAACGCCCACCCCGGAGAGGTCCACCTCACAGTGGCC
GTGCTGGCGTACAGGACCCAAGATGGGCTGGGCCCCCTACACTACGGGGTCTGCTCCACA
TGGCTGAGCCAGCTCAAGACTGGAGACCCCGTGCCCTGCTTCATCAGGGGGGCTCCCTCC
TTCCGGCTGCCGCCTGACCCCTACGTGCCCTGCATCCTCGTGGGCCCTGGCACTGGCATC
GCCCCCTTCCGGGGATTTTGGCAGGAGAGGCTGCATGACATTGAGAGCAAAGGGCTGCAG
CCCGCCCCCATGACCCTGGTGTTCGGCTGCCGCTGCTCCCAACTCGACCATCTCTACCGC
GACGAGGTGCAGGACGCCCAGGAGCGCGGGGTGTTTGGCCGCGTCCTCACCGCCTTCTCC
CGGGAACCTGACAGCCCCAAGACCTACGTACAGGACATCCTGAGAACCGAGCTGGCTGCC
GAGGTGCACCGCGTGCTGTGCCTCGAGCGGGGCCACATGTTTGTCTGCGGCGATGTCACT
ATGGCAACCAGCGTCCTGCAGACGGTGCAGCGCATCTTGGCGACAGAGGGCGACATGGAG
CTGGACGAGGCGGGCGACGTCATCGGCGTGCTGCGGGATCAGCAACGCTATCACGAGGAC
ATTTTCGGCCTCACGCTGCGCACCCAGGAGGTGACAAGCCGTATACGTACCCAGAGCTTT
TCCCTGCAGGAGCGGCATCTGCGGGGCGCGGTGCCCTGGGCCTTCGACCCGCCCGGCCCA
GACACCCCCGGCCCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1205 |
| Molecular Weight
| 133287.0 |
| Theoretical pI
| 6.92 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Nitric oxide synthase, endothelial
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSRAPAPATPHAPDHSPAPNSPT
LTRPPEGPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRCCLGSLVLPRKLQTRPSPGPP
PAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVASTGTYHLRESELVFGAKQAW
RNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGR
GDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDE
APELFVLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWYM
STEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIV
DHHAATVSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQPD
PWKGSATKGAGITRKKTFKEVANAVKISASLMGTLMAKRVKATILYASETGRAQSYAQQL
GRLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYN
SSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYP
HFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAKAAFQASCETFCVGEEAKA
AAQDIFSPKRSWKRQRYRLSTQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSKSTRAT
ILVRLDTAGQEGLQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPTESVAVEQLEKGSPG
GPPPSWVRDPRLPPCTLRQALTFFLDITSPPSPRLLRLLSTLAEEPSEQQELETLSQDPR
RYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPNAHPGEVHLTVA
VLAYRTQDGLGPLHYGVCSTWLSQLKTGDPVPCFIRGAPSFRLPPDPYVPCILVGPGTGI
APFRGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQERGVFGRVLTAFS
REPDSPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDME
LDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWAFDPPGP
DTPGP
|
| External Links |
|---|
| GenBank ID Protein
| AAA30667.1 |
| UniProtKB/Swiss-Prot ID
| P29473 |
| UniProtKB/Swiss-Prot Entry Name
| NOS3_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| M99057 |
| GeneCard ID
| NOS3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
