Showing Protein Nitric oxide synthase, endothelial (BMDBP00022)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP00022 | ||
| Secondary Accession Numbers | None | ||
| Name | Nitric oxide synthase, endothelial | ||
| Synonyms | Not Available | ||
| Gene Name | NOS3 | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Inorganic ion transport and metabolism | ||
| Specific Function | Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. | ||
| Pathways |
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| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 4 | ||
| Locus | Not Available | ||
| SNPs | NOS3 | ||
| Gene Sequence |
>3618 bp ATGGGCAACTTGAAGAGTGTGGGCCAGGAGCCCGGGCCCCCCTGCGGCCTGGGGCTGGGG CTGGGCCTCGGGCTATGCGGCAAGCAGGGCCCAGCCTCCCCGGCACCTGAGCCCAGCCGG GCCCCCGCACCCGCCACCCCGCACGCGCCAGACCACAGCCCAGCTCCCAACAGCCCCACG CTGACCCGGCCTCCGGAGGGGCCCAAGTTCCCTCGCGTGAAGAACTGGGAGCTGGGGAGC ATCACCTACGACACTCTGTGCGCGCAGTCCCAACAGGACGGGCCCTGCACTCCCAGGTGC TGCCTGGGCTCCCTGGTGTTGCCCCGGAAACTGCAGACCCGGCCCTCCCCGGGACCTCCA CCCGCTGAGCAGCTGCTGAGCCAGGCCAGGGACTTCATCAACCAGTACTACAGCTCCATC AAGAGGAGCGGCTCCCAGGCTCACGAGGAGCGGCTTCAGGAGGTGGAGGCCGAGGTGGCA TCCACGGGCACCTACCACCTCCGAGAGAGCGAGCTGGTGTTCGGGGCCAAGCAGGCCTGG CGCAACGCACCCCGCTGCGTGGGCCGCATCCAGTGGGGGAAGCTGCAGGTGTTTGATGCC CGGGACTGCAGCTCAGCACAGGAGATGTTCACCTACATCTGCAACCACATCAAGTACGCC ACCAACCGCGGCAACCTTCGCTCGGCCATCACAGTGTTCCCGCAGCGCGCCCCGGGCCGC GGAGACTTCCGGATCTGGAACAGCCAGCTGGTGCGCTACGCAGGCTACAGACAGCAGGAT GGCTCTGTGCGTGGGGACCCAGCCAATGTGGAGATCACGGAGCTCTGCATCCAGCACGGC TGGACCCCCGGAAACGGCCGCTTCGACGTGCTGCCCCTGCTGCTCCAGGCCCCAGACGAG GCTCCAGAGCTCTTTGTTCTGCCCCCCGAGCTGGTCCTTGAAGTGCCCCTGGAGCACCCC ACACTGGAGTGGTTCGCGGCCCTGGGCCTGCGATGGTATGCCCTCCCGGCCGTGTCCAAC ATGCTGCTGGAAATCGGGGGTCTGGAGTTCTCCGCGGCCCCCTTCAGCGGCTGGTACATG AGCACGGAGATTGGCACGCGGAACCTGTGTGACCCTCACCGCTACAATATCCTGGAGGAT GTGGCCGTCTGCATGGACCTCGACACGCGGACCACCTCGTCCCTGTGGAAGGACAAGGCG GCCGTGGAGATCAACCTGGCTGTGCTGCACAGCTTTCAGCTCGCCAAGGTGACCATCGTG GACCACCACGCCGCCACGGTGTCCTTCATGAAGCACCTGGACAACGAGCAGAAGGCCAGG GGGGGCTGCCCCGCCGACTGGGCCTGGATCGTGCCCCCCATCTCAGGCAGCCTCACGCCC GTCTTCCACCAGGAGATGGTCAACTACATCCTGTCCCCTGCCTTCCGCTACCAGCCAGAC CCCTGGAAAGGGAGCGCGACCAAGGGCGCAGGCATCACCAGGAAGAAGACCTTTAAGGAA GTGGCCAACGCGGTGAAGATCTCTGCCTCACTCATGGGCACCCTGATGGCCAAGCGAGTG AAAGCAACCATCCTGTACGCCTCTGAGACCGGCCGGGCCCAGAGCTACGCTCAGCAGCTG GGGAGGCTCTTCCGGAAGGCCTTCGATCCCCGGGTCCTGTGCATGGATGAGTATGACGTG GTGTCCCTGGAGCACGAGGCGCTGGTACTGGTGGTGACCAGCACCTTTGGGAATGGCGAT CCCCCGGAGAATGGAGAGAGTTTTGCAGCTGCCCTGATGGAGATGTCGGGGCCCTACAAC AGCTCCCCGCGGCCGGAACAGCACAAGAGTTACAAGATCCGCTTCAACAGCGTCTCCTGC TCAGACCCGCTGGTGTCCTCCTGGCGGCGGAAGAGAAAGGAGTCCAGCAACACAGACAGT GCGGGGGCCCTGGGGACCCTCAGGTTCTGTGTGTTCGGACTGGGCTCCCGGGCATACCCC CACTTCTGCGCCTTCGCGCGAGCGGTGGACACCCGGCTGGAAGAGCTTGGAGGGGAGCGG CTGCTGCAGCTGGGCCAGGGCGATGAGCTCTGCGGCCAGGAAGAGGCCTTCCGTGGTTGG GCAAAGGCGGCCTTCCAGGCCTCCTGTGAGACCTTCTGCGTTGGGGAGGAGGCCAAGGCC GCCGCCCAGGACATCTTCAGCCCCAAACGGAGCTGGAAACGCCAGAGGTACCGGCTGAGC ACCCAGGCCGAGGGCCTCCAGCTGCTGCCAGGCCTGATCCACGTGCACAGACGGAAGATG TTTCAGGCCACAGTCCTCTCGGTGGAAAATCTGCAAAGCAGCAAGTCCACCCGGGCCACC ATCCTGGTGCGCCTGGACACTGCAGGCCAGGAGGGGCTGCAGTACCAGCCGGGGGACCAC ATAGGCATCTGCCCGCCCAACCGGCCGGGCCTGGTGGAGGCGCTGCTGAGCCGCGTGGAG GACCCGCCACCGCCCACCGAGTCTGTGGCTGTGGAGCAGCTGGAGAAAGGCAGCCCAGGC GGCCCTCCTCCCAGCTGGGTGCGGGACCCACGGCTGCCCCCGTGCACGCTGCGCCAGGCT CTCACCTTCTTCCTGGACATCACCTCCCCACCCAGCCCCCGGCTTCTCCGACTGCTCAGC ACCCTGGCCGAAGAACCCAGCGAGCAGCAGGAGCTTGAGACCCTCAGTCAGGACCCCCGG CGCTACGAGGAGTGGAAGTGGTTCCGCTGCCCCACGCTGCTGGAGGTGCTGGAGCAGTTC CCGTCCGTGGCGCTGCCCGCCCCGCTGCTCCTCACCCAGCTGCCCCTGCTGCAGCCCCGG TACTACTCTGTCAGCTCGGCCCCCAACGCCCACCCCGGAGAGGTCCACCTCACAGTGGCC GTGCTGGCGTACAGGACCCAAGATGGGCTGGGCCCCCTACACTACGGGGTCTGCTCCACA TGGCTGAGCCAGCTCAAGACTGGAGACCCCGTGCCCTGCTTCATCAGGGGGGCTCCCTCC TTCCGGCTGCCGCCTGACCCCTACGTGCCCTGCATCCTCGTGGGCCCTGGCACTGGCATC GCCCCCTTCCGGGGATTTTGGCAGGAGAGGCTGCATGACATTGAGAGCAAAGGGCTGCAG CCCGCCCCCATGACCCTGGTGTTCGGCTGCCGCTGCTCCCAACTCGACCATCTCTACCGC GACGAGGTGCAGGACGCCCAGGAGCGCGGGGTGTTTGGCCGCGTCCTCACCGCCTTCTCC CGGGAACCTGACAGCCCCAAGACCTACGTACAGGACATCCTGAGAACCGAGCTGGCTGCC GAGGTGCACCGCGTGCTGTGCCTCGAGCGGGGCCACATGTTTGTCTGCGGCGATGTCACT ATGGCAACCAGCGTCCTGCAGACGGTGCAGCGCATCTTGGCGACAGAGGGCGACATGGAG CTGGACGAGGCGGGCGACGTCATCGGCGTGCTGCGGGATCAGCAACGCTATCACGAGGAC ATTTTCGGCCTCACGCTGCGCACCCAGGAGGTGACAAGCCGTATACGTACCCAGAGCTTT TCCCTGCAGGAGCGGCATCTGCGGGGCGCGGTGCCCTGGGCCTTCGACCCGCCCGGCCCA GACACCCCCGGCCCCTGA |
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| Protein Properties | |||
| Number of Residues | 1205 | ||
| Molecular Weight | 133287.0 | ||
| Theoretical pI | 6.92 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>Nitric oxide synthase, endothelial MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSRAPAPATPHAPDHSPAPNSPT LTRPPEGPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRCCLGSLVLPRKLQTRPSPGPP PAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVASTGTYHLRESELVFGAKQAW RNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGR GDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDE APELFVLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWYM STEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIV DHHAATVSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQPD PWKGSATKGAGITRKKTFKEVANAVKISASLMGTLMAKRVKATILYASETGRAQSYAQQL GRLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYN SSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYP HFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAKAAFQASCETFCVGEEAKA AAQDIFSPKRSWKRQRYRLSTQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSKSTRAT ILVRLDTAGQEGLQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPTESVAVEQLEKGSPG GPPPSWVRDPRLPPCTLRQALTFFLDITSPPSPRLLRLLSTLAEEPSEQQELETLSQDPR RYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPNAHPGEVHLTVA VLAYRTQDGLGPLHYGVCSTWLSQLKTGDPVPCFIRGAPSFRLPPDPYVPCILVGPGTGI APFRGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQERGVFGRVLTAFS REPDSPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDME LDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWAFDPPGP DTPGP |
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| External Links | |||
| GenBank ID Protein | AAA30667.1 | ||
| UniProtKB/Swiss-Prot ID | P29473 | ||
| UniProtKB/Swiss-Prot Entry Name | NOS3_BOVIN | ||
| PDB IDs |
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| GenBank Gene ID | M99057 | ||
| GeneCard ID | NOS3 | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||