Showing Protein Steroid 17-alpha-hydroxylase/17,20 lyase (BMDBP00040)
| Identification | |||||||||
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| BMDB Protein ID | BMDBP00040 | ||||||||
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| Name | Steroid 17-alpha-hydroxylase/17,20 lyase | ||||||||
| Synonyms | Not Available | ||||||||
| Gene Name | CYP17A1 | ||||||||
| Protein Type | Enzyme | ||||||||
| Biological Properties | |||||||||
| General Function | Secondary metabolites biosynthesis, transport and catabolism | ||||||||
| Specific Function | A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). | ||||||||
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| GO Classification | Not Available | ||||||||
| Cellular Location | Not Available | ||||||||
| Gene Properties | |||||||||
| Chromosome Location | 26 | ||||||||
| Locus | 26q22-q31 | ||||||||
| SNPs | CYP17A1 | ||||||||
| Gene Sequence |
>1530 bp GACTGCTGCCACCCAGACACAATGTGGCTGCTCCTGGCTGTCTTTCTGCTCACCCTCGCC TATTTATTTTGGCCCAAGACCAAGCACTCTGGTGCCAAGTACCCCAGGAGCCTCCCATCC CTGCCCCTGGTGGGCAGCCTGCCGTTCCTCCCCAGACGTGGCCAGCAGCACAAGAACTTC TTCAAGCTGCAGGAAAAATATGGCCCCATCTATTCCTTTCGTTTGGGTTCCAAGACGACT GTGATGATTGGACACCACCAGTTGGCCAGGGAGGTGCTTCTCAAGAAGGGCAAGGAATTC TCTGGGCGTCCCAAAGTGGCCACTCTAGACATCCTGTCAGACAACCAAAAGGGCATTGCC TTTGCCGACCATGGTGCCCACTGGCAGCTGCATCGGAAGCTGGCACTGAATGCCTTTGCC CTGTTCAAGGATGGCAACCTGAAGTTAGAGAAGATCATTAATCAGGAAGCCAATGTGCTC TGTGATTTCCTGGCCACCCAGCATGGAGAGGCCATAGATCTGTCCGAGCCTCTCTCTCTG GCGGTGACCAACATAATCAGCTTTATCTGCTTCAACTTCTCCTTCAAGAATGAGGATCCT GCCCTGAAGGCCATACAAAATGTCAATGATGGCATCCTGGAGGTTCTGAGCAAGGAAGTT CTGTTAGACATATTCCCTGTGCTGAAGATTTTCCCCAGCAAAGCCATGGAAAAGATGAAG GGTTGTGTTCAAACGCGAAATGAATTGCTGAATGAAATCCTTGAAAAATGTCAGGAGAAC TTCAGCAGTGATTCCATCACTAACTTGCTGCACATACTGATCCAAGCCAAGGTGAATGCA GACAATAACAATGCTGGCCCAGACCAGGATTCAAAGCTGCTTTCAAATAGACACATGCTC GCTACTATAGGGGACATCTTCGGGGCTGGTGTGGAGACCACCACGTCTGTGATAAAGTGG ATCGTGGCCTACCTGCTACACCATCCTTCGTTGAAGAAGAGGATCCAGGATGACATTGAC CAGATTATAGGTTTCAATCGCACCCCAACCATCAGTGACCGGAACCGCCTTGTCCTGCTG GAGGCGACCATCAGAGAAGTGCTCCGAATCCGGCCTGTGGCCCCTACGCTGATCCCCCAC AAGGCTGTCATTGACTCCAGCATTGGCGACCTTACCATTGACAAAGGCACAGACGTTGTG GTCAACCTGTGGGCACTGCATCACAGTGAGAAGGAGTGGCAGCATCCCGACCTGTTCATG CCCGAGCGCTTCTTGGACCCCACGGGGACGCAACTCATCTCGCCATCATTAAGCTACTTG CCCTTTGGAGCAGGACCCCGCTCCTGCGTAGGTGAGATGCTAGCCCGCCAGGAGCTCTTC CTCTTCATGTCCCGGCTGCTGCAGAGGTTCAACCTGGAGATCCCGGATGATGGGAAGCTA CCTTCTCTGGAGGGCCATGCCAGTCTCGTCTTGCAGATCAAACCTTTCAAGGTGAAGATC GAGGTGCGCCAGGCCTGGAAGGAAGCCCAG |
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| Protein Properties | |||||||||
| Number of Residues | 509 | ||||||||
| Molecular Weight | 57244.0 | ||||||||
| Theoretical pI | 8.9 | ||||||||
| Pfam Domain Function | Not Available | ||||||||
| Signals |
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| Transmembrane Regions | Not Available | ||||||||
| Protein Sequence |
>Steroid 17-alpha-hydroxylase/17,20 lyase MWLLLAVFLLTLAYLFWPKTKHSGAKYPRSLPSLPLVGSLPFLPRRGQQHKNFFKLQEKY GPIYSFRLGSKTTVMIGHHQLAREVLLKKGKEFSGRPKVATLDILSDNQKGIAFADHGAH WQLHRKLALNAFALFKDGNLKLEKIINQEANVLCDFLATQHGEAIDLSEPLSLAVTNIIS FICFNFSFKNEDPALKAIQNVNDGILEVLSKEVLLDIFPVLKIFPSKAMEKMKGCVQTRN ELLNEILEKCQENFSSDSITNLLHILIQAKVNADNNNAGPDQDSKLLSNRHMLATIGDIF GAGVETTTSVIKWIVAYLLHHPSLKKRIQDDIDQIIGFNRTPTISDRNRLVLLEATIREV LRIRPVAPTLIPHKAVIDSSIGDLTIDKGTDVVVNLWALHHSEKEWQHPDLFMPERFLDP TGTQLISPSLSYLPFGAGPRSCVGEMLARQELFLFMSRLLQRFNLEIPDDGKLPSLEGHA SLVLQIKPFKVKIEVRQAWKEAQAEGSTP |
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| External Links | |||||||||
| GenBank ID Protein | AAA30485.1 | ||||||||
| UniProtKB/Swiss-Prot ID | P05185 | ||||||||
| UniProtKB/Swiss-Prot Entry Name | CP17A_BOVIN | ||||||||
| PDB IDs | Not Available | ||||||||
| GenBank Gene ID | M12547 | ||||||||
| GeneCard ID | CYP17A1 | ||||||||
| GenAtlas ID | Not Available | ||||||||
| HGNC ID | Not Available | ||||||||
| References | |||||||||
| General References | Not Available | ||||||||