Showing Protein Cytochrome P450 2U1 (BMDBP00042)
| Identification | |||||
|---|---|---|---|---|---|
| BMDB Protein ID | BMDBP00042 | ||||
| Secondary Accession Numbers | None | ||||
| Name | Cytochrome P450 2U1 | ||||
| Synonyms | Not Available | ||||
| Gene Name | CYP2U1 | ||||
| Protein Type | Enzyme | ||||
| Biological Properties | |||||
| General Function | Secondary metabolites biosynthesis, transport and catabolism | ||||
| Specific Function | A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May downregulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin. | ||||
| Pathways |
|
||||
| Reactions |
|
||||
| GO Classification | Not Available | ||||
| Cellular Location | Not Available | ||||
| Gene Properties | |||||
| Chromosome Location | 6 | ||||
| Locus | Not Available | ||||
| SNPs | CYP2U1 | ||||
| Gene Sequence |
>1632 bp ATGGCCTCCCCCGGGCTTCCCCAGCCCCCCACCGAGGACGCGGCCTGGCCTCTGCGCCTC CTGCACGCGCCCCCGGGGCTGCTGCGGCTGGACCCCACGGGCGGCGCGCTGCTGCTGCTC GTCCTCGCCGCGCTGCTGGGCTGGAGCTGGCTGTGGCGGCTCCCGGAGCGGGGCATCCCC CCCGGGCCCGCGCCCTGGCCCGTGGTGGGCAACTTCGGCTTCGTGCTGCTGCCGCGTTTT CTCCGAAGGAAGAGCTGGCCGTATCGCCGAGCGAGAAACGGAGGAATGAATGCCTCGGGC CAGGGCGTGCAGTTGCTCCTGGCCGACCTGGGCCGTGTGTACGGCAACATCTTTAGCTTC CTCATCGGCCACTACCTGGTGGTGGTCCTCAACGACTTCCACAGCGTGCGGGAGGCGCTG GTGCAGCAGGCCGAGGTCTTCAGCGACCGCCCGCGGGTGCCGCTGACCTCCATCATGACC AAGGGAAAGGGGATTGTATTTGCACATTATGGTCCAGTCTGGAGACAACAGAGGAAGTTC TCTCATTCAACTCTTCGTCATTTTGGCTTGGGAAAGCTTAGCTTGGAGCCCAAGATTATT GAGGAGTTCAGATATGTGAAAGAGGAAATGCAAAAGCACGGAGACGCCCCTTTCAATCCT TTCCCCATTGTCAACAACGCCGTCTCTAACATCATCTGCTCCTTGTGCTTTGGTCGGCGC TTTGATTACACTAATAGTGAATTTAAGCAAATGCTTAATTTTATGTCACGAGCATTAGAA GTTTGTCTGAACACCCAGCTCCTCCTGGTCAACATATGCTCCTGGCTTTATTACCTTCCT TTTGGACCATTTAAGGAATTAAGACAGATTGAAAAGGATTTAACCCTTTTCCTTAAAAAA ATCATCAAAGATCATCGAGAGTCTTTGGATGTAGAGAACCCTCAGGACTTCATAGACATG TATCTTCTCCATGTGGAGGAGGAGAAGAAAAATAACAGCAATAGTGGGTTTGATGAAGAT TACTTATTTTACATCATCGGCGATCTCTTCATTGCTGGCACTGATACCACAACTAACTCT TTGCTTTGGTGCCTCCTGTATATGTCACTGCACCCCAACATTCAAGAAAAGATTCATGAA GAAATTGCAAGGGTCATTGGTGCTGACCGCGCCCCCTCCCTCACTGACAAGGCGCAGATG CCCTACACAGAAGCCACCATCATGGAGGTGCAGAGGCTGAGCACTGTGGTGCCGCTATCC ATCCCTCACATGACCTCAGAGAAAACAGTGCTCCAAGGTTTTACCATTCCTAAAGGCACA ATAATATTACCCAACCTATGGTCAGTACACAGAGACCCAGCCATCTGGGAGAAACCAAAT GATTTCTACCCTGATCGATTTCTGGATGATCAAGGACAACTTATTAAAAAGGAAACGTTT ATTCCTTTTGGGATAGGGAAGCGGGTGTGTATGGGAGAGCAGCTGGCAAAGATGGAGTTG TTCCTGATGTTCGTGAGCCTAATGCAGAGTTTCACGTTTGTTTTACCTAAGGATTCAAAG CCAATCCTGACTGGGAAATATGGTCTAACTTTAGCCCCACATCCATTTAATATAATCATT TCAAAGAGATAA |
||||
| Protein Properties | |||||
| Number of Residues | 543 | ||||
| Molecular Weight | 61997.0 | ||||
| Theoretical pI | 8.87 | ||||
| Pfam Domain Function | Not Available | ||||
| Signals |
|
||||
| Transmembrane Regions |
|
||||
| Protein Sequence |
>Cytochrome P450 2U1 MASPGLPQPPTEDAAWPLRLLHAPPGLLRLDPTGGALLLLVLAALLGWSWLWRLPERGIP PGPAPWPVVGNFGFVLLPRFLRRKSWPYRRARNGGMNASGQGVQLLLADLGRVYGNIFSF LIGHYLVVVLNDFHSVREALVQQAEVFSDRPRVPLTSIMTKGKGIVFAHYGPVWRQQRKF SHSTLRHFGLGKLSLEPKIIEEFRYVKEEMQKHGDAPFNPFPIVNNAVSNIICSLCFGRR FDYTNSEFKQMLNFMSRALEVCLNTQLLLVNICSWLYYLPFGPFKELRQIEKDLTLFLKK IIKDHRESLDVENPQDFIDMYLLHVEEEKKNNSNSGFDEDYLFYIIGDLFIAGTDTTTNS LLWCLLYMSLHPNIQEKIHEEIARVIGADRAPSLTDKAQMPYTEATIMEVQRLSTVVPLS IPHMTSEKTVLQGFTIPKGTIILPNLWSVHRDPAIWEKPNDFYPDRFLDDQGQLIKKETF IPFGIGKRVCMGEQLAKMELFLMFVSLMQSFTFVLPKDSKPILTGKYGLTLAPHPFNIII SKR |
||||
| External Links | |||||
| GenBank ID Protein | AAI22664.1 | ||||
| UniProtKB/Swiss-Prot ID | Q0IIF9 | ||||
| UniProtKB/Swiss-Prot Entry Name | CP2U1_BOVIN | ||||
| PDB IDs | Not Available | ||||
| GenBank Gene ID | BC122663 | ||||
| GeneCard ID | CYP2U1 | ||||
| GenAtlas ID | Not Available | ||||
| HGNC ID | Not Available | ||||
| References | |||||
| General References | Not Available | ||||