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Showing Protein Nitric oxide synthase, inducible (BMDBP00069)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00069 |
| Secondary Accession Numbers | None |
| Name | Nitric oxide synthase, inducible |
| Synonyms | Not Available |
| Gene Name | NOS2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Inorganic ion transport and metabolism |
| Specific Function | Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 19 |
| Locus | Not Available |
| SNPs | NOS2 |
| Gene Sequence |
>3471 bp ATGGCCTGTCCCTGGCAGTTTCTGTTCAAAATCAAATCCCAAAAGGTGGACTTGGCTACG GAACTGGACATCAACAACAATGTGGGAAAATTCTACCAGCCCCCGTCCAGTCCAGTGACA CAGGATGACCCCAAACGTCACAGCCCGGGCAAGCACGGGAATGAGTCTCCCCAGCCCCTC ACGGGGACAGTAAAGACGTCTCCAGAATCCCTGAGCAAGCTGGACGCGCCCCCGTCAGCC TGTCCACGGCATGTGAGGATCAAAAACTGGGGCAGCGGAGTGACTTTCCAAGACACGCTT CACCAGAAGGCCAAAGGGGATCTCTCTTGCAAGTCCAAGTCTTGCCTGGCATCCATCATG AACCCCAAAAGTTTGACCATAGGACCCCGGGACAAGCCAACCCCCCCAGACGAGCTTCTA CCTCAAGCTATCGAATTTGTCAACCAGTATTACGGCTCCTTCAAAGAGGCAAAAATAGAG GAACATCTGGCCAGGGTGGAAGCAGTAACAAAGGAGATAGAAACAACAGGAACCTACCAG CTGACGGGAGATGAGCTCATCTTCGCCACCAAGCAGGCCTGGCGCAACGCCCCCCGCTGC ATCGGAAGGATCCAGTGGTCGAACCTGCAGGTCTTTGACGCCCGGAGCTGTTCCACGGCC CAGGAAATGTTCGAACACATCTGCAGACACGTGCGTTATGCCACCAACAACGGCAACATC AGGTCGGCCATCACTGTGTTCCCCCAGCGGAGCGATGGGAAGCATGACTTCCGGGTCTGG AACGCCCAGCTCATCCGCTATGCCGGCTACCAGATGCCAGATGGCAGCATCAGAGGGGAC CCCGCCAACGTGGAGTTCACACAGCTGTGCATCGACCTGGGCTGGAAGCCCAAGTACGGC CGCTTCGACGTGTTGCCTCTAGTCCTGCAGGCTGACGGCCGTGACCCAGAGCTCTTCGAA ATCCCCCCTGACCTTGTTCTCGAGGTGCCCATGGAACATCCCAGGTACGAATGGTTCCGG GAGCTGGAGCTCAAGTGGTACGCCCTGCCAGCCGTGGCCAACATGCTGCTTGAGGTGGGC GGCCTCGAGTTCCCAGGGTGCCCCTTCAACGGGTGGTACATGGGCACAGAAGTTGGAGTC CGGGACTTCTGCGACGCCCAGCGATACAACATCCTGGAGGAAGTGGGCAGAAGGATGGGC CTGGAAACGCACAAGGTGGCCTCACTCTGGAAGGACCGGGCTGTCGTTGAGATCAACGTC GCTGTGCTCCACAGTTTCCAGAAGCAGAACGTGACCATCATGGACCACCACTCCGCTGCA GAGTCCTTCATGAAGTACATGCAGAATGAGTACCGCTCCCGAGGGGGCTGCCCAGCTGAC TGGATTTGGCTGGTCCCCCCGATCTCTGGAAGCATCACCCCCGTGTTCCACCAGGAGATG TTAAATTACGTCCTGTCCCCTTTCTACTACTACCAGGTGGAGCCCTGGAAAACCCACGTC TGGCAGGACGAGAGGCGGAGACCCCAGAGAAGAGAAATTCGATTCAAAGTCTTGGTCAAA GCCGTGTTCTTCGCCTCGGTGCTGATGCATAAGGCCATGGCATCCCGGGTCAGAGCCACG ATCCTCTTTGCAACAGAGACGGGGAGATCGGAAACGCTGGCCCAGGACCTGGGGGCTTTG TTCAGCTGTGCCTTCAACCCCAAGGTTCTCTGCATGGATCAGTACCAGCTGAGCCATCTG GAGGAGGARCAGCTGCTGCTGGTGGTGACCAGCACTTTTGGCAACGGAGACTCCCCTGGC AACGGAGAGAAACTGAAGAAGTCCCTCTTGATGCTGAAAGAACTCACCAACACGTTCCGG TACGCCGTGTTTGGCCTTGGCTCCAGCATGTACCCTCAGTTCTGCGCTTTTGCTCATGAC ATTGACCAGAAGTTGTCCCAGCTGGGGGCTTCTCAGCTTGCCCCAACCGGGGAAGGGGAC GAACTCAGCGGGCAGGAGGAGGCCTTTCGCAGCTGGGCCGTGCAAACCTTCAAGGCAGCC TGTGAGACATTCGATGTCAGCGGCAAGCACCACATTGAGATCCCCAAGCTCTACACTTCC AATGTGACCTGGGACCCGCAGCACTACAGGCTCGTGCAGGACTCAGAGCCTCTGGACCTC AACAAAGCCCTGAGCAGTATGCACGCCAAGCATGTGTTCACCATGAGGCTCAAATCGCAG CAGAATCTGCAGAGTCCGAAATCCAGCCGCACCACCCTCCTGGTGGAACTCTCCTGTGAG GGCAGCCAAGCTCCAAGCTACCTGCCGGGAGAGCACCTCGGAGTTTTCCCATGCAACCAG CCGGCCCTGGTTCAAGGCATCCTTGAGCGAGTGGTGGATGGCCCTGCCCCGCACCAGCCT GTGCGCCTGGAGACCCTCTGTGAGAATGGCAGCTATTGGGTCAAGGATAAGCGGCTGCCA CCTTGCTCACTCAGCCAGGCTCTCACCTATTTCCTGGACATCACCACCCCGCCAACCCAG CTGCTGCTCCGAAAGCTGGCCCAGCTGGCCACAGAAGAGGCTGAGAAGCAGAGGCTGGAG ACCCTATGCCAGCCCTCAGATTACAACAAGTGGAAGTTCACCAACAGCCCCACATTTCTG GAGGTGCTGGAGGAGTTCCCGTCCCTGCGGGTGTCTGCCAGCTTCCTGCTCTCCCAGCTC CCTATTCTGAAGCCCCGGTACTACTCCATCAGCTCCTCCAGGGACCTCACACCCACGGAG ATCCACCTCACTGTGGCCGTGCTCACGTACCGCACCCGAGATGGCCAAGGTCCCCTGCAC CATGGTGTCTGCAGCACGTGGCTCAGCAGCTTGAAGCCCCAAGACCCGGTGCCCTGCTTT GTGCGAAGTGCCAGYGGCTTCCAGCTTCCCGAGGACCGCTCCCGTCCTTGCATCCTCATT GGGCCCGGCACGGGCATCGCCCCCTTCCGCAGTTTCTGGCAGCAGCGGCTCCATGAGGCT GAGCACAAAGGGCTCCAGGGCGGCCGCATGACCCTGGTTTTCGGGTGCCGCCGCCCAGAA GAGGACCACCTCTACTGGGAGGAGATGCTGGAGATGGCCCGCAAGGGGGTGCTGCACGAG GTGCACACCGCCTATTCCCGCCTGCCTGACCAGCCCAAGGTCTATGTTCAAGACATCCTG CGGCAGCGGCTGGCGGGCGAGGTGCTTCGCGTGCTCCATGAGGAGCAAGGTCACCTCTAT GTCTGTGGGGATGTGCGCATGGCCCGGGACGTGGCCCGCACCCTGAAGCAGCTGATGGCT ACTGCGCTGAGCCTGAACGAGGAACAGGTGGAGGACTATTTCTTCCAGCTCAAGAACCAG AAGCGCTATCATGAAGACATCTTTGGTGCTGTATTTCCCTATGAGGTGAAAAAGGATGGG GCAGCAGGGCTGCCCAGCAATCCCAGAGCTCCAGGCGCCCACAGAAGTTAA |
| Protein Properties | |
| Number of Residues | 1156 |
| Molecular Weight | 131208.0 |
| Theoretical pI | 7.42 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Nitric oxide synthase, inducible MACPWQFLFKIKSQKVDLATELDINNNVGKFYQPPSSPVTQDDPKRHSPGKHGNESPQPL TGTVKTSPESLSKLDAPPSACPRHVRIKNWGSGVTFQDTLHQKAKGDLSCKSKSCLASIM NPKSLTIGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAQEMFEHICRHVRYATNNGNI RSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYG RFDVLPLVLQADGRDPELFEIPPDLVLEVPMEHPRYEWFRELELKWYALPAVANMLLEVG GLEFPGCPFNGWYMGTEVGVRDFCDAQRYNILEEVGRRMGLETHKVASLWKDRAVVEINV AVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPISGSITPVFHQEM LNYVLSPFYYYQVEPWKTHVWQDERRRPQRREIRFKVLVKAVFFASVLMHKAMASRVRAT ILFATETGRSETLAQDLGALFSCAFNPKVLCMDQYQLSHLEEEQLLLVVTSTFGNGDSPG NGEKLKKSLLMLKELTNTFRYAVFGLGSSMYPQFCAFAHDIDQKLSQLGASQLAPTGEGD ELSGQEEAFRSWAVQTFKAACETFDVSGKHHIEIPKLYTSNVTWDPQHYRLVQDSEPLDL NKALSSMHAKHVFTMRLKSQQNLQSPKSSRTTLLVELSCEGSQAPSYLPGEHLGVFPCNQ PALVQGILERVVDGPAPHQPVRLETLCENGSYWVKDKRLPPCSLSQALTYFLDITTPPTQ LLLRKLAQLATEEAEKQRLETLCQPSDYNKWKFTNSPTFLEVLEEFPSLRVSASFLLSQL PILKPRYYSISSSRDLTPTEIHLTVAVLTYRTRDGQGPLHHGVCSTWLSSLKPQDPVPCF VRSASGFQLPEDRSRPCILIGPGTGIAPFRSFWQQRLHEAEHKGLQGGRMTLVFGCRRPE EDHLYWEEMLEMARKGVLHEVHTAYSRLPDQPKVYVQDILRQRLAGEVLRVLHEEQGHLY VCGDVRMARDVARTLKQLMATALSLNEEQVEDYFFQLKNQKRYHEDIFGAVFPYEVKKDG AAGLPSNPRAPGAHRS |
| External Links | |
| GenBank ID Protein | ABG74910.1 |
| UniProtKB/Swiss-Prot ID | Q27995 |
| UniProtKB/Swiss-Prot Entry Name | NOS2_BOVIN |
| PDB IDs | |
| GenBank Gene ID | DQ676956 |
| GeneCard ID | NOS2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |