| Identification |
|---|
| BMDB Protein ID
| BMDBP00069 |
| Secondary Accession Numbers
| None |
| Name
| Nitric oxide synthase, inducible |
| Synonyms
|
Not Available
|
| Gene Name
| NOS2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Inorganic ion transport and metabolism |
| Specific Function
| Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| NOS2 |
| Gene Sequence
|
>3471 bp
ATGGCCTGTCCCTGGCAGTTTCTGTTCAAAATCAAATCCCAAAAGGTGGACTTGGCTACG
GAACTGGACATCAACAACAATGTGGGAAAATTCTACCAGCCCCCGTCCAGTCCAGTGACA
CAGGATGACCCCAAACGTCACAGCCCGGGCAAGCACGGGAATGAGTCTCCCCAGCCCCTC
ACGGGGACAGTAAAGACGTCTCCAGAATCCCTGAGCAAGCTGGACGCGCCCCCGTCAGCC
TGTCCACGGCATGTGAGGATCAAAAACTGGGGCAGCGGAGTGACTTTCCAAGACACGCTT
CACCAGAAGGCCAAAGGGGATCTCTCTTGCAAGTCCAAGTCTTGCCTGGCATCCATCATG
AACCCCAAAAGTTTGACCATAGGACCCCGGGACAAGCCAACCCCCCCAGACGAGCTTCTA
CCTCAAGCTATCGAATTTGTCAACCAGTATTACGGCTCCTTCAAAGAGGCAAAAATAGAG
GAACATCTGGCCAGGGTGGAAGCAGTAACAAAGGAGATAGAAACAACAGGAACCTACCAG
CTGACGGGAGATGAGCTCATCTTCGCCACCAAGCAGGCCTGGCGCAACGCCCCCCGCTGC
ATCGGAAGGATCCAGTGGTCGAACCTGCAGGTCTTTGACGCCCGGAGCTGTTCCACGGCC
CAGGAAATGTTCGAACACATCTGCAGACACGTGCGTTATGCCACCAACAACGGCAACATC
AGGTCGGCCATCACTGTGTTCCCCCAGCGGAGCGATGGGAAGCATGACTTCCGGGTCTGG
AACGCCCAGCTCATCCGCTATGCCGGCTACCAGATGCCAGATGGCAGCATCAGAGGGGAC
CCCGCCAACGTGGAGTTCACACAGCTGTGCATCGACCTGGGCTGGAAGCCCAAGTACGGC
CGCTTCGACGTGTTGCCTCTAGTCCTGCAGGCTGACGGCCGTGACCCAGAGCTCTTCGAA
ATCCCCCCTGACCTTGTTCTCGAGGTGCCCATGGAACATCCCAGGTACGAATGGTTCCGG
GAGCTGGAGCTCAAGTGGTACGCCCTGCCAGCCGTGGCCAACATGCTGCTTGAGGTGGGC
GGCCTCGAGTTCCCAGGGTGCCCCTTCAACGGGTGGTACATGGGCACAGAAGTTGGAGTC
CGGGACTTCTGCGACGCCCAGCGATACAACATCCTGGAGGAAGTGGGCAGAAGGATGGGC
CTGGAAACGCACAAGGTGGCCTCACTCTGGAAGGACCGGGCTGTCGTTGAGATCAACGTC
GCTGTGCTCCACAGTTTCCAGAAGCAGAACGTGACCATCATGGACCACCACTCCGCTGCA
GAGTCCTTCATGAAGTACATGCAGAATGAGTACCGCTCCCGAGGGGGCTGCCCAGCTGAC
TGGATTTGGCTGGTCCCCCCGATCTCTGGAAGCATCACCCCCGTGTTCCACCAGGAGATG
TTAAATTACGTCCTGTCCCCTTTCTACTACTACCAGGTGGAGCCCTGGAAAACCCACGTC
TGGCAGGACGAGAGGCGGAGACCCCAGAGAAGAGAAATTCGATTCAAAGTCTTGGTCAAA
GCCGTGTTCTTCGCCTCGGTGCTGATGCATAAGGCCATGGCATCCCGGGTCAGAGCCACG
ATCCTCTTTGCAACAGAGACGGGGAGATCGGAAACGCTGGCCCAGGACCTGGGGGCTTTG
TTCAGCTGTGCCTTCAACCCCAAGGTTCTCTGCATGGATCAGTACCAGCTGAGCCATCTG
GAGGAGGARCAGCTGCTGCTGGTGGTGACCAGCACTTTTGGCAACGGAGACTCCCCTGGC
AACGGAGAGAAACTGAAGAAGTCCCTCTTGATGCTGAAAGAACTCACCAACACGTTCCGG
TACGCCGTGTTTGGCCTTGGCTCCAGCATGTACCCTCAGTTCTGCGCTTTTGCTCATGAC
ATTGACCAGAAGTTGTCCCAGCTGGGGGCTTCTCAGCTTGCCCCAACCGGGGAAGGGGAC
GAACTCAGCGGGCAGGAGGAGGCCTTTCGCAGCTGGGCCGTGCAAACCTTCAAGGCAGCC
TGTGAGACATTCGATGTCAGCGGCAAGCACCACATTGAGATCCCCAAGCTCTACACTTCC
AATGTGACCTGGGACCCGCAGCACTACAGGCTCGTGCAGGACTCAGAGCCTCTGGACCTC
AACAAAGCCCTGAGCAGTATGCACGCCAAGCATGTGTTCACCATGAGGCTCAAATCGCAG
CAGAATCTGCAGAGTCCGAAATCCAGCCGCACCACCCTCCTGGTGGAACTCTCCTGTGAG
GGCAGCCAAGCTCCAAGCTACCTGCCGGGAGAGCACCTCGGAGTTTTCCCATGCAACCAG
CCGGCCCTGGTTCAAGGCATCCTTGAGCGAGTGGTGGATGGCCCTGCCCCGCACCAGCCT
GTGCGCCTGGAGACCCTCTGTGAGAATGGCAGCTATTGGGTCAAGGATAAGCGGCTGCCA
CCTTGCTCACTCAGCCAGGCTCTCACCTATTTCCTGGACATCACCACCCCGCCAACCCAG
CTGCTGCTCCGAAAGCTGGCCCAGCTGGCCACAGAAGAGGCTGAGAAGCAGAGGCTGGAG
ACCCTATGCCAGCCCTCAGATTACAACAAGTGGAAGTTCACCAACAGCCCCACATTTCTG
GAGGTGCTGGAGGAGTTCCCGTCCCTGCGGGTGTCTGCCAGCTTCCTGCTCTCCCAGCTC
CCTATTCTGAAGCCCCGGTACTACTCCATCAGCTCCTCCAGGGACCTCACACCCACGGAG
ATCCACCTCACTGTGGCCGTGCTCACGTACCGCACCCGAGATGGCCAAGGTCCCCTGCAC
CATGGTGTCTGCAGCACGTGGCTCAGCAGCTTGAAGCCCCAAGACCCGGTGCCCTGCTTT
GTGCGAAGTGCCAGYGGCTTCCAGCTTCCCGAGGACCGCTCCCGTCCTTGCATCCTCATT
GGGCCCGGCACGGGCATCGCCCCCTTCCGCAGTTTCTGGCAGCAGCGGCTCCATGAGGCT
GAGCACAAAGGGCTCCAGGGCGGCCGCATGACCCTGGTTTTCGGGTGCCGCCGCCCAGAA
GAGGACCACCTCTACTGGGAGGAGATGCTGGAGATGGCCCGCAAGGGGGTGCTGCACGAG
GTGCACACCGCCTATTCCCGCCTGCCTGACCAGCCCAAGGTCTATGTTCAAGACATCCTG
CGGCAGCGGCTGGCGGGCGAGGTGCTTCGCGTGCTCCATGAGGAGCAAGGTCACCTCTAT
GTCTGTGGGGATGTGCGCATGGCCCGGGACGTGGCCCGCACCCTGAAGCAGCTGATGGCT
ACTGCGCTGAGCCTGAACGAGGAACAGGTGGAGGACTATTTCTTCCAGCTCAAGAACCAG
AAGCGCTATCATGAAGACATCTTTGGTGCTGTATTTCCCTATGAGGTGAAAAAGGATGGG
GCAGCAGGGCTGCCCAGCAATCCCAGAGCTCCAGGCGCCCACAGAAGTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1156 |
| Molecular Weight
| 131208.0 |
| Theoretical pI
| 7.42 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Nitric oxide synthase, inducible
MACPWQFLFKIKSQKVDLATELDINNNVGKFYQPPSSPVTQDDPKRHSPGKHGNESPQPL
TGTVKTSPESLSKLDAPPSACPRHVRIKNWGSGVTFQDTLHQKAKGDLSCKSKSCLASIM
NPKSLTIGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ
LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAQEMFEHICRHVRYATNNGNI
RSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYG
RFDVLPLVLQADGRDPELFEIPPDLVLEVPMEHPRYEWFRELELKWYALPAVANMLLEVG
GLEFPGCPFNGWYMGTEVGVRDFCDAQRYNILEEVGRRMGLETHKVASLWKDRAVVEINV
AVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPISGSITPVFHQEM
LNYVLSPFYYYQVEPWKTHVWQDERRRPQRREIRFKVLVKAVFFASVLMHKAMASRVRAT
ILFATETGRSETLAQDLGALFSCAFNPKVLCMDQYQLSHLEEEQLLLVVTSTFGNGDSPG
NGEKLKKSLLMLKELTNTFRYAVFGLGSSMYPQFCAFAHDIDQKLSQLGASQLAPTGEGD
ELSGQEEAFRSWAVQTFKAACETFDVSGKHHIEIPKLYTSNVTWDPQHYRLVQDSEPLDL
NKALSSMHAKHVFTMRLKSQQNLQSPKSSRTTLLVELSCEGSQAPSYLPGEHLGVFPCNQ
PALVQGILERVVDGPAPHQPVRLETLCENGSYWVKDKRLPPCSLSQALTYFLDITTPPTQ
LLLRKLAQLATEEAEKQRLETLCQPSDYNKWKFTNSPTFLEVLEEFPSLRVSASFLLSQL
PILKPRYYSISSSRDLTPTEIHLTVAVLTYRTRDGQGPLHHGVCSTWLSSLKPQDPVPCF
VRSASGFQLPEDRSRPCILIGPGTGIAPFRSFWQQRLHEAEHKGLQGGRMTLVFGCRRPE
EDHLYWEEMLEMARKGVLHEVHTAYSRLPDQPKVYVQDILRQRLAGEVLRVLHEEQGHLY
VCGDVRMARDVARTLKQLMATALSLNEEQVEDYFFQLKNQKRYHEDIFGAVFPYEVKKDG
AAGLPSNPRAPGAHRS
|
| External Links |
|---|
| GenBank ID Protein
| ABG74910.1 |
| UniProtKB/Swiss-Prot ID
| Q27995 |
| UniProtKB/Swiss-Prot Entry Name
| NOS2_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| DQ676956 |
| GeneCard ID
| NOS2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
