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| Identification |
|---|
| BMDB Protein ID
| BMDBP00149 |
| Secondary Accession Numbers
| None |
| Name
| Cytosolic purine 5'-nucleotidase |
| Synonyms
|
Not Available
|
| Gene Name
| NT5C2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in 5'-nucleotidase activity |
| Specific Function
| May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. |
| Pathways
|
- Nicotinate and Nicotinamide Metabolism
- Purine Metabolism
- Pyrimidine Metabolism
|
| Reactions
|
| 2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Hydrogen phosphate |
details
|
| Guanosine monophosphate + Water → Guanosine + Hydrogen phosphate |
details
|
| Xanthylic acid + Water → Xanthosine + Hydrogen phosphate |
details
|
| Inosinic acid + Water → Inosine + Hydrogen phosphate |
details
|
| Deoxyadenosine monophosphate + Water → Deoxyadenosine + Hydrogen phosphate |
details
|
| Nicotinamide riboside + Hydrogen phosphate → Nicotinamide ribotide + Water |
details
|
| Nicotinic acid mononucleotide + Water → Nicotinate D-ribonucleoside + Hydrogen phosphate |
details
|
| Uridine 5'-monophosphate + Water → Uridine + Hydrogen phosphate |
details
|
| dCMP + Water → Deoxycytidine + Hydrogen phosphate |
details
|
| 5-Thymidylic acid + Water → Thymidine + Hydrogen phosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 26 |
| Locus
| Not Available |
| SNPs
| NT5C2 |
| Gene Sequence
|
>1683 bp
ATGACAACCTCCTGGAGTGATCGGTTACAAAATGCAGCAGATATGCCTGCTAACATGGAT
AAACATGCCCTGAAAAAGTATCGGCGAGAAGCCTATCATCGGGTGTTTGTGAACCGGAGT
TTAGCCATGGAAAAAATAAAGTGTTTTGGGTTTGACATGGATTATACACTTGCTGTGTAC
AAGTCCCCGGAGTATGAGTCCCTTGGCTTTGAGCTTACTGTGGAGAGATTAGTTTCTATT
GGCTATCCTCAGGAACTTCTCAGCTTTGCATATGACTCTACATTCCCTACCAGGGGACTA
GTATTTGATACACTGTATGGAAATCTTTTGAAAGTTGATGCCTATGGAAACCTCTTGGTC
TGTGCACATGGATTTAACTTCATAAGGGGACCAGAAACTAGAGAGCAGTATCCAAATAAA
TTTATTCAACGAGATGACACTGAAAGATTTTACATTCTGAACACACTATTCAACCTACCA
GAGACCTACCTGTTGGCCTGCCTAGTAGATTTTTTTACTAATTGTCCCAGATACACCAGC
TGTGAAACAGGATTTAAAGATGGGGACCTCTTCATGTCTTACCGGAGTATGTTCCAGGAT
GTAAGAGACGCAGTTGACTGGGTTCATTACAAGGGTTCCCTTAAGGAAAAGACAGTTGAA
AATCTTGAGAAGTATGTAGTCAAAGATGGAAAACTGCCTTTGCTTCTGAGCCGGATGAAG
GAAGTAGGAAAAGTATTTCTTGCCACCAACAGTGACTATAAATATACAGATAAAATTATG
ACTTACCTGTTTGATTTCCCACATGGCCCCAAGCCTGGGAGCTCTCATCGGCCGTGGCAG
TCCTACTTTGACCTGATCTTGGTGGACGCACGGAAACCACTGTTCTTCGGAGAAGGCACA
GTACTGCGTCAGGTGGATACTAAAACTGGCAAGCTGAAAATTGGTACCTACACGGGCCCC
TTACAGCATGGCATCGTCTACTCTGGGGGTTCATCTGATACAGTTTGTGACCTGTTGGGA
GCCAAGGGCAAAGATATTTTGTATATTGGAGATCACATTTTTGGGGACATTTTAAAATCA
AAGAAACGGCAAGGGTGGCGAACTTTCTTGGTGATTCCTGAACTCGCACAGGAACTGCAT
GTCTGGACCGATAAGAGTTCACTTTTCGAAGAGCTTCAGAGCTTGGATATTTTCTTGGCT
GAACTCTACAAGCACCTTGACAGCAGCAGCAATGAGCGCCCAGATATCAGCTCCATCCAA
AGACGTATTAAGAAAGTAACTCACGACATGGACATGTGCTACGGGATGATGGGGAGCCTG
TTCCGCAGTGGCTCCCGGCAGACCCTTTTCGCCAGTCAGGTGATGCGCTATGCTGATCTC
TACGCAGCATCTTTCATCAACCTGCTGTACTACCCATTCAGCTACCTCTTCAGAGCGGCC
CACGTCTTGATGCCTCATGAGTCAACAGTGGAACACACACATGTAGATATCAATGAGATG
GAGTCCCCTCTCGCCACCCGGAACCGCACATCAGTGGATTTCAAAGATACCGACTACAAG
CGGCACCAACTGACACGGTCGATTAGTGAGATTAAGCCCCCCAACCTCTTCCCACTGGCC
CCCCAGGAAATTACACACTGCCATGACGAAGATGATGATGAGGAGGAAGAAGAGGAGGAG
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 560 |
| Molecular Weight
| 64841.0 |
| Theoretical pI
| 6.15 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 86-106
- 130-150
- 287-306
- 319-336
- 771-790
- 801-821
- 842-864
- 917-936
- 950-968
- 984-1004
|
| Protein Sequence
|
>Cytosolic purine 5'-nucleotidase
MTTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVY
KSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLV
CAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTS
CETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMK
EVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGT
VLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTVCDLLGAKGKDILYIGDHIFGDILKS
KKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQ
RRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAA
HVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLA
PQEITHCHDEDDDEEEEEEE
|
| External Links |
|---|
| GenBank ID Protein
| AAC48784.1 |
| UniProtKB/Swiss-Prot ID
| O46411 |
| UniProtKB/Swiss-Prot Entry Name
| 5NTC_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U73690 |
| GeneCard ID
| NT5C2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
