Identification
BMDB Protein ID BMDBP00149
Secondary Accession Numbers None
Name Cytosolic purine 5'-nucleotidase
Synonyms Not Available
Gene Name NT5C2
Protein Type Enzyme
Biological Properties
General Function Involved in 5'-nucleotidase activity
Specific Function May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.
Pathways
  • Nicotinate and Nicotinamide Metabolism
  • Purine Metabolism
  • Pyrimidine Metabolism
Reactions
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Hydrogen phosphate details
Guanosine monophosphate + Water → Guanosine + Hydrogen phosphate details
Xanthylic acid + Water → Xanthosine + Hydrogen phosphate details
Inosinic acid + Water → Inosine + Hydrogen phosphate details
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Hydrogen phosphate details
Nicotinamide riboside + Hydrogen phosphate → Nicotinamide ribotide + Water details
Nicotinic acid mononucleotide + Water → Nicotinate D-ribonucleoside + Hydrogen phosphate details
Uridine 5'-monophosphate + Water → Uridine + Hydrogen phosphate details
dCMP + Water → Deoxycytidine + Hydrogen phosphate details
5-Thymidylic acid + Water → Thymidine + Hydrogen phosphate details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 26
Locus Not Available
SNPs NT5C2
Gene Sequence
>1683 bp
ATGACAACCTCCTGGAGTGATCGGTTACAAAATGCAGCAGATATGCCTGCTAACATGGAT
AAACATGCCCTGAAAAAGTATCGGCGAGAAGCCTATCATCGGGTGTTTGTGAACCGGAGT
TTAGCCATGGAAAAAATAAAGTGTTTTGGGTTTGACATGGATTATACACTTGCTGTGTAC
AAGTCCCCGGAGTATGAGTCCCTTGGCTTTGAGCTTACTGTGGAGAGATTAGTTTCTATT
GGCTATCCTCAGGAACTTCTCAGCTTTGCATATGACTCTACATTCCCTACCAGGGGACTA
GTATTTGATACACTGTATGGAAATCTTTTGAAAGTTGATGCCTATGGAAACCTCTTGGTC
TGTGCACATGGATTTAACTTCATAAGGGGACCAGAAACTAGAGAGCAGTATCCAAATAAA
TTTATTCAACGAGATGACACTGAAAGATTTTACATTCTGAACACACTATTCAACCTACCA
GAGACCTACCTGTTGGCCTGCCTAGTAGATTTTTTTACTAATTGTCCCAGATACACCAGC
TGTGAAACAGGATTTAAAGATGGGGACCTCTTCATGTCTTACCGGAGTATGTTCCAGGAT
GTAAGAGACGCAGTTGACTGGGTTCATTACAAGGGTTCCCTTAAGGAAAAGACAGTTGAA
AATCTTGAGAAGTATGTAGTCAAAGATGGAAAACTGCCTTTGCTTCTGAGCCGGATGAAG
GAAGTAGGAAAAGTATTTCTTGCCACCAACAGTGACTATAAATATACAGATAAAATTATG
ACTTACCTGTTTGATTTCCCACATGGCCCCAAGCCTGGGAGCTCTCATCGGCCGTGGCAG
TCCTACTTTGACCTGATCTTGGTGGACGCACGGAAACCACTGTTCTTCGGAGAAGGCACA
GTACTGCGTCAGGTGGATACTAAAACTGGCAAGCTGAAAATTGGTACCTACACGGGCCCC
TTACAGCATGGCATCGTCTACTCTGGGGGTTCATCTGATACAGTTTGTGACCTGTTGGGA
GCCAAGGGCAAAGATATTTTGTATATTGGAGATCACATTTTTGGGGACATTTTAAAATCA
AAGAAACGGCAAGGGTGGCGAACTTTCTTGGTGATTCCTGAACTCGCACAGGAACTGCAT
GTCTGGACCGATAAGAGTTCACTTTTCGAAGAGCTTCAGAGCTTGGATATTTTCTTGGCT
GAACTCTACAAGCACCTTGACAGCAGCAGCAATGAGCGCCCAGATATCAGCTCCATCCAA
AGACGTATTAAGAAAGTAACTCACGACATGGACATGTGCTACGGGATGATGGGGAGCCTG
TTCCGCAGTGGCTCCCGGCAGACCCTTTTCGCCAGTCAGGTGATGCGCTATGCTGATCTC
TACGCAGCATCTTTCATCAACCTGCTGTACTACCCATTCAGCTACCTCTTCAGAGCGGCC
CACGTCTTGATGCCTCATGAGTCAACAGTGGAACACACACATGTAGATATCAATGAGATG
GAGTCCCCTCTCGCCACCCGGAACCGCACATCAGTGGATTTCAAAGATACCGACTACAAG
CGGCACCAACTGACACGGTCGATTAGTGAGATTAAGCCCCCCAACCTCTTCCCACTGGCC
CCCCAGGAAATTACACACTGCCATGACGAAGATGATGATGAGGAGGAAGAAGAGGAGGAG
TGA
Protein Properties
Number of Residues 560
Molecular Weight 64841.0
Theoretical pI 6.15
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • 86-106
  • 130-150
  • 287-306
  • 319-336
  • 771-790
  • 801-821
  • 842-864
  • 917-936
  • 950-968
  • 984-1004
Protein Sequence
>Cytosolic purine 5'-nucleotidase
MTTSWSDRLQNAADMPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVY
KSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLV
CAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTS
CETGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMK
EVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGT
VLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTVCDLLGAKGKDILYIGDHIFGDILKS
KKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQ
RRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAA
HVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLA
PQEITHCHDEDDDEEEEEEE
GenBank ID Protein AAC48784.1
UniProtKB/Swiss-Prot ID O46411
UniProtKB/Swiss-Prot Entry Name 5NTC_BOVIN
PDB IDs Not Available
GenBank Gene ID U73690
GeneCard ID NT5C2
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available