Showing Protein Folylpolyglutamate synthase, mitochondrial (BMDBP00169)
| Identification | |||||
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| BMDB Protein ID | BMDBP00169 | ||||
| Secondary Accession Numbers | None | ||||
| Name | Folylpolyglutamate synthase, mitochondrial | ||||
| Synonyms | Not Available | ||||
| Gene Name | FPGS | ||||
| Protein Type | Enzyme | ||||
| Biological Properties | |||||
| General Function | Coenzyme transport and metabolism | ||||
| Specific Function | Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. | ||||
| Pathways |
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| Reactions |
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| GO Classification | Not Available | ||||
| Cellular Location | Not Available | ||||
| Gene Properties | |||||
| Chromosome Location | 11 | ||||
| Locus | Not Available | ||||
| SNPs | FPGS | ||||
| Gene Sequence |
>1758 bp ATGTCTCGGGCACGCTGCCACGCTCTCTTCCTGGCAGCGGTTTCTCCGCGTGGTGCAACA ACCAGGGTCGCAGTGCGGCGAGGGTTGAGCGCGTGGCCTGTGCTGCAGGAGCCAGACATG GAGTATCAGGATGCCGTGCGTACACTCAACACCCTGCAGACCAATGCTAACTACTTGGAG ATGGTGAAGCGTAAGCGGGGTGACCCCCAGACACAGCTGGAAGCCATGAAGCTGTACTTG GCACGGAGTGGGCTGCAGGTGGAGGACTTGGACCAGCTGAACATTATCCACATCACTGGA ACCAAGGGGAAGGGCTCCACGTGTGCCTTCACTGAACGTATCCTCCGAAGCTATGGCCTG AAGACGGGGTTCTTTAGCTCTCCCCACCTGGTGCAGGTGCGTGAGCGGATCCGCATCAAT GGGCAGCCCATAAGCTCCGAGCTCTTCACCAAGCACTTCTGGCGCCTCTACCACCGGCTG GAGGAGACCAAGGACGACAGCAGCTGTGTCTCCATGCCCGGCTACTTCCGCTTCCTCACG CTCATGGCCTTCCACGTCTTCCTCCAAGAGAAGGTAGACCTGGCAGTGTTGGAAGTAGGC ATTGGCGGGGCTTACGACTGCACCAACATCATCAGGAAGCCTGTGGTGTGTGGGATCACC TCTCTTGGCATCGACCACACTGGCCTTCTGGGGGACACGATGGAGAAGATCGCATGGCAG AAAGGGGGCATTTTTAAGAGTGGCGTCCCTGCCTTCACCGTGCTCCAGCCTGACGAGCCG CTGGCGGTGCTAAGGGACAGGGCTCAGCAGATCTCATGTCCCCTCTACCTGTGCCCACCA CTACAAGCCCTGGAGGAAGGGGGGCCACCACTGACCCTGGGCCTGGAGGGAGAGCACCAG CGGTCCAATGCTGCCCTGGCCTTGCAGGTGGCCCGCTGCTGGCTGCAGCAGAAAGGTTAC CAGGATGCTGGGGAGCTGAAGGCATCCAGGCCCAGCCTCCCGGGGCAGCTGCCCCTGGCA CCTGTGTTCCAGCCCACGCCCCGCATGCAGCAGGGGCTTCGGCACACGGAATGGCCAGGT CGGACGCAGTTGCTGCGGCGCGGGCCTCTTACCTGGTACCTGGACGGCGCGCACACCACC AGCAGCATGCAAGCCTGTGTGCGCTGGTTCCGCCAGGCGCTGCACCGCTGCGAGAGGCCG GACAGCGGTTCCGAGGTGCGCGTCTTGCTCTTCAACTCCACTGGGGACCGGGATTCCGCG GCCCTGCTGAAGCTGCTGCAGCCCTGCCAGTTTGACTATGCCATTTTCTGCCCTAACCTG GCAGAGATGGCATCAACAGACAATGCAGACCAACAGAACTTCACAGTGACACTGGACCAG GTGCTGCTCCGCTGCCTCGCCCACCAACAGCACTGGAGTCGCCTGCATGAGGAGCAGGTC AGCCCGGACCCCTGGAGCACCCCCGGCCAGGAGCAGGATGGGCCCGCATCTCTGCTGCTG GCGCCTCACCCACCCCACACCCACAGTGCCAGCTCCCTCGTCTTCAGCTGCATCTCCCAT GCCTTGCAGTGGATCACCCAAGGCCGGGACCCTCTCTTTCAGCCGCCCAGTCCCCCACGG GGCCTCCTCGCCCACCCTGTGGCAGACAGTGGGGCCACGGTACTCCAAGAGGCTGCTGAC ATTCACGTGCTGGTCACAGGCAGCCTGCACCTGGTGGGCGGTGTCCTGAAGCTGCTGGAG CCCTCCCTGTCCCAGTAG |
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| Protein Properties | |||||
| Number of Residues | 585 | ||||
| Molecular Weight | 64900.0 | ||||
| Theoretical pI | 7.73 | ||||
| Pfam Domain Function | Not Available | ||||
| Signals |
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| Transmembrane Regions | Not Available | ||||
| Protein Sequence |
>Folylpolyglutamate synthase, mitochondrial MSRARCHALFLAAVSPRGATTRVAVRRGLSAWPVLQEPDMEYQDAVRTLNTLQTNANYLE MVKRKRGDPQTQLEAMKLYLARSGLQVEDLDQLNIIHITGTKGKGSTCAFTERILRSYGL KTGFFSSPHLVQVRERIRINGQPISSELFTKHFWRLYHRLEETKDDSSCVSMPGYFRFLT LMAFHVFLQEKVDLAVLEVGIGGAYDCTNIIRKPVVCGITSLGIDHTGLLGDTMEKIAWQ KGGIFKSGVPAFTVLQPDEPLAVLRDRAQQISCPLYLCPPLQALEEGGPPLTLGLEGEHQ RSNAALALQVARCWLQQKGYQDAGELKASRPSLPGQLPLAPVFQPTPRMQQGLRHTEWPG RTQLLRRGPLTWYLDGAHTTSSMQACVRWFRQALHRCERPDSGSEVRVLLFNSTGDRDSA ALLKLLQPCQFDYAIFCPNLAEMASTDNADQQNFTVTLDQVLLRCLAHQQHWSRLHEEQV SPDPWSTPGQEQDGPASLLLAPHPPHTHSASSLVFSCISHALQWITQGRDPLFQPPSPPR GLLAHPVADSGATVLQEAADIHVLVTGSLHLVGGVLKLLEPSLSQ |
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| External Links | |||||
| GenBank ID Protein | AAI46115.1 | ||||
| UniProtKB/Swiss-Prot ID | A6H751 | ||||
| UniProtKB/Swiss-Prot Entry Name | FOLC_BOVIN | ||||
| PDB IDs | Not Available | ||||
| GenBank Gene ID | BC146114 | ||||
| GeneCard ID | FPGS | ||||
| GenAtlas ID | Not Available | ||||
| HGNC ID | Not Available | ||||
| References | |||||
| General References | Not Available | ||||