| Identification |
|---|
| BMDB Protein ID
| BMDBP00169 |
| Secondary Accession Numbers
| None |
| Name
| Folylpolyglutamate synthase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| FPGS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Coenzyme transport and metabolism |
| Specific Function
| Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. |
| Pathways
|
- Cofactor biosynthesis
- Folate Metabolism
- Tetrahydrofolylpolyglutamate biosynthesis
|
| Reactions
|
| Tetrahydrofolic acid + L-Glutamic acid + Adenosine triphosphate → Tetrahydrofolyl-[Glu](2) + ADP + Hydrogen phosphate |
details
|
| Tetrahydrofolyl-[Glu](2) + Adenosine triphosphate + L-Glutamic acid → Tetrahydrofolyl-[Glu](n) + ADP + Hydrogen phosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| Not Available |
| SNPs
| FPGS |
| Gene Sequence
|
>1758 bp
ATGTCTCGGGCACGCTGCCACGCTCTCTTCCTGGCAGCGGTTTCTCCGCGTGGTGCAACA
ACCAGGGTCGCAGTGCGGCGAGGGTTGAGCGCGTGGCCTGTGCTGCAGGAGCCAGACATG
GAGTATCAGGATGCCGTGCGTACACTCAACACCCTGCAGACCAATGCTAACTACTTGGAG
ATGGTGAAGCGTAAGCGGGGTGACCCCCAGACACAGCTGGAAGCCATGAAGCTGTACTTG
GCACGGAGTGGGCTGCAGGTGGAGGACTTGGACCAGCTGAACATTATCCACATCACTGGA
ACCAAGGGGAAGGGCTCCACGTGTGCCTTCACTGAACGTATCCTCCGAAGCTATGGCCTG
AAGACGGGGTTCTTTAGCTCTCCCCACCTGGTGCAGGTGCGTGAGCGGATCCGCATCAAT
GGGCAGCCCATAAGCTCCGAGCTCTTCACCAAGCACTTCTGGCGCCTCTACCACCGGCTG
GAGGAGACCAAGGACGACAGCAGCTGTGTCTCCATGCCCGGCTACTTCCGCTTCCTCACG
CTCATGGCCTTCCACGTCTTCCTCCAAGAGAAGGTAGACCTGGCAGTGTTGGAAGTAGGC
ATTGGCGGGGCTTACGACTGCACCAACATCATCAGGAAGCCTGTGGTGTGTGGGATCACC
TCTCTTGGCATCGACCACACTGGCCTTCTGGGGGACACGATGGAGAAGATCGCATGGCAG
AAAGGGGGCATTTTTAAGAGTGGCGTCCCTGCCTTCACCGTGCTCCAGCCTGACGAGCCG
CTGGCGGTGCTAAGGGACAGGGCTCAGCAGATCTCATGTCCCCTCTACCTGTGCCCACCA
CTACAAGCCCTGGAGGAAGGGGGGCCACCACTGACCCTGGGCCTGGAGGGAGAGCACCAG
CGGTCCAATGCTGCCCTGGCCTTGCAGGTGGCCCGCTGCTGGCTGCAGCAGAAAGGTTAC
CAGGATGCTGGGGAGCTGAAGGCATCCAGGCCCAGCCTCCCGGGGCAGCTGCCCCTGGCA
CCTGTGTTCCAGCCCACGCCCCGCATGCAGCAGGGGCTTCGGCACACGGAATGGCCAGGT
CGGACGCAGTTGCTGCGGCGCGGGCCTCTTACCTGGTACCTGGACGGCGCGCACACCACC
AGCAGCATGCAAGCCTGTGTGCGCTGGTTCCGCCAGGCGCTGCACCGCTGCGAGAGGCCG
GACAGCGGTTCCGAGGTGCGCGTCTTGCTCTTCAACTCCACTGGGGACCGGGATTCCGCG
GCCCTGCTGAAGCTGCTGCAGCCCTGCCAGTTTGACTATGCCATTTTCTGCCCTAACCTG
GCAGAGATGGCATCAACAGACAATGCAGACCAACAGAACTTCACAGTGACACTGGACCAG
GTGCTGCTCCGCTGCCTCGCCCACCAACAGCACTGGAGTCGCCTGCATGAGGAGCAGGTC
AGCCCGGACCCCTGGAGCACCCCCGGCCAGGAGCAGGATGGGCCCGCATCTCTGCTGCTG
GCGCCTCACCCACCCCACACCCACAGTGCCAGCTCCCTCGTCTTCAGCTGCATCTCCCAT
GCCTTGCAGTGGATCACCCAAGGCCGGGACCCTCTCTTTCAGCCGCCCAGTCCCCCACGG
GGCCTCCTCGCCCACCCTGTGGCAGACAGTGGGGCCACGGTACTCCAAGAGGCTGCTGAC
ATTCACGTGCTGGTCACAGGCAGCCTGCACCTGGTGGGCGGTGTCCTGAAGCTGCTGGAG
CCCTCCCTGTCCCAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 585 |
| Molecular Weight
| 64900.0 |
| Theoretical pI
| 7.73 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Folylpolyglutamate synthase, mitochondrial
MSRARCHALFLAAVSPRGATTRVAVRRGLSAWPVLQEPDMEYQDAVRTLNTLQTNANYLE
MVKRKRGDPQTQLEAMKLYLARSGLQVEDLDQLNIIHITGTKGKGSTCAFTERILRSYGL
KTGFFSSPHLVQVRERIRINGQPISSELFTKHFWRLYHRLEETKDDSSCVSMPGYFRFLT
LMAFHVFLQEKVDLAVLEVGIGGAYDCTNIIRKPVVCGITSLGIDHTGLLGDTMEKIAWQ
KGGIFKSGVPAFTVLQPDEPLAVLRDRAQQISCPLYLCPPLQALEEGGPPLTLGLEGEHQ
RSNAALALQVARCWLQQKGYQDAGELKASRPSLPGQLPLAPVFQPTPRMQQGLRHTEWPG
RTQLLRRGPLTWYLDGAHTTSSMQACVRWFRQALHRCERPDSGSEVRVLLFNSTGDRDSA
ALLKLLQPCQFDYAIFCPNLAEMASTDNADQQNFTVTLDQVLLRCLAHQQHWSRLHEEQV
SPDPWSTPGQEQDGPASLLLAPHPPHTHSASSLVFSCISHALQWITQGRDPLFQPPSPPR
GLLAHPVADSGATVLQEAADIHVLVTGSLHLVGGVLKLLEPSLSQ
|
| External Links |
|---|
| GenBank ID Protein
| AAI46115.1 |
| UniProtKB/Swiss-Prot ID
| A6H751 |
| UniProtKB/Swiss-Prot Entry Name
| FOLC_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC146114 |
| GeneCard ID
| FPGS |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
