Showing Protein Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (BMDBP00260)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 11 metabolites
Identification
BMDB Protein ID BMDBP00260
Secondary Accession Numbers None
Name Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
Synonyms Not Available
Gene Name ALDH6A1
Protein Type Enzyme
Biological Properties
General Function Energy production and conversion
Specific Function Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.
Pathways
  • beta-Alanine Metabolism
  • Propanoate Metabolism
  • Valine, Leucine, and Isoleucine Degradation
Reactions
Malonic semialdehyde + Coenzyme A + NAD → Acetyl-CoA + Carbon dioxide + NADH details
(S)-Methylmalonic acid semialdehyde + Water + NAD + Coenzyme A → Propionyl-CoA + NADH + Hydrogen carbonate details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 10
Locus Not Available
SNPs ALDH6A1
Gene Sequence 
>1614 bp
ATGGCGGCTGTGGCGGTGGCGGCGGCGGCGGCTGCATTGCGGGCCCGGATCCTGCAGGTC
TCTTCCAAGGTGAATTCCAGTTGGCAGCCAGCATCCTCCTTCTCTTCGTCTTCAGTGCCA
ACTGTAAAACTCTTCATTGATGGGAAATTTATTGAATCCAAAAGTGACAAATGGATCGAC
ATCCACAATCCCGCCACCAATGAGGTCATTGGTCGGGTCCCTGAGTCCACCAAGGCCGAA
ATGGATGCAGCAGTTTCTTCCTGCAAACGTACTTTTCCCGCGTGGGCAGACACTTCAATA
TTAAGCCGTCAGCAGGTCCTGCTCCGCTACCAACAACTCATTAAAGAAAATTTGAAAGAA
ATTGCCAGGTTGATCATGCTGGAACAAGGGAAGACCCTGGCGGATGCTGAAGGAGATGTG
TTTCGAGGCCTCCAGGTGGTTGAGCATGCCTGCAGTGTGACATCCCTCATGCTGGGGGAC
ACCATGCCATCCATCACCAAAGACATGGACCTTTATTCCTACCGTCTGCCTCTGGGGGTA
TGCGCAGGCATTGCTCCGTTCAATTTTCCTGCCATGATCCCCCTTTGGATGTTTCCCATG
GCCATGGTGTGTGGAAATACCTTCCTGATGAAACCATCAGAGCGAGTCCCTGGAGCAACT
ATGCTTCTCGCCAAGCTGTTTCAGGACTCTGGTGCCCCTGATGGAACACTGAATATCATC
CATGGACAACATGAAGCTGTAAATTTTATTTGCGATCATCCGGATATCAAAGCAATCAGC
TTTGTGGGATCCAACCAGGCAGGAGAGTACATCTTCGAGCGAGGGTCAAGACATGGCAAG
AGAGTTCAAGCCAATATGGGAGCCAAGAACCATGGAGTAGTCATGCCAGATGCGAATAAG
GAAAACACCCTGAACCAGTTGGTTGGGGCAGCATTTGGAGCTGCTGGTCAGCGCTGCATG
GCTCTTTCAACAGCAATCCTTGTGGGAGAAGCTAAGAAGTGGCTGCCAGAGCTGGTAGAA
CGTGCCAAAAAACTAAGAGTGAATGCAGGAGACCAGCCTGGAGCTGATCTTGGCCCTCTG
ATCACCCCCCAGGCAAAAGAGCGTGTCTGTAATCTGATTGATAGTGGAACAAAGGAAGGA
GCTTCCATCCTTCTTGACGGGCGAAGTATTAAAGTCAAAGGTTATGAAAATGGGAACTTT
GTTGGGCCAACCATCATTTCAAATGTCAAGCCAAACATGACCTGTTACAAGGAGGAGATT
TTTGGCCCAGTTCTTGTAGTTCTGGAAACAGACACTTTGGATGAAGCCATCAAGATTGTA
AATGACAACCCATATGGAAATGGAACAGCCATCTTCACCACCAATGGAGCCACTGCTCGG
AAATATTCCCACCTGGTGGATGTTGGACAGGTTGGGGTGAATGTGCCCATTCCAGTGCCT
TTGCCAATGTTCTCATTCACGGGCTCTCGCGCTTCCTTCAGGGGAGACACCAATTTCTAT
GGCAAACAGGGCATCCAATTCTATACTCAGCTAAAGACTATCACTTCTCAATGGAAAGAA
GAAGATGCTTCTCTTTCCTCACCTGCTGTAGTCATGCCTACCATGGGCCGTTAG
Protein Properties
Number of Residues 537
Molecular Weight 58063.0
Theoretical pI 8.2
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence 
>Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
MAAVAVAAAAAALRARILQVSSKVNSSWQPASSFSSSSVPTVKLFIDGKFIESKSDKWID
IHNPATNEVIGRVPESTKAEMDAAVSSCKRTFPAWADTSILSRQQVLLRYQQLIKENLKE
IARLIMLEQGKTLADAEGDVFRGLQVVEHACSVTSLMLGDTMPSITKDMDLYSYRLPLGV
CAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLFQDSGAPDGTLNII
HGQHEAVNFICDHPDIKAISFVGSNQAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANK
ENTLNQLVGAAFGAAGQRCMALSTAILVGEAKKWLPELVERAKKLRVNAGDQPGADLGPL
ITPQAKERVCNLIDSGTKEGASILLDGRSIKVKGYENGNFVGPTIISNVKPNMTCYKEEI
FGPVLVVLETDTLDEAIKIVNDNPYGNGTAIFTTNGATARKYSHLVDVGQVGVNVPIPVP
LPMFSFTGSRASFRGDTNFYGKQGIQFYTQLKTITSQWKEEDASLSSPAVVMPTMGR
GenBank ID Protein AAA30650.1
UniProtKB/Swiss-Prot ID Q07536
UniProtKB/Swiss-Prot Entry Name MMSA_BOVIN
PDB IDs Not Available
GenBank Gene ID L08643
GeneCard ID ALDH6A1
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available