Showing Protein 3-ketoacyl-CoA thiolase, mitochondrial (BMDBP00369)
| Identification | |||||
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| BMDB Protein ID | BMDBP00369 | ||||
| Secondary Accession Numbers |
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| Name | 3-ketoacyl-CoA thiolase, mitochondrial | ||||
| Synonyms | Not Available | ||||
| Gene Name | ACAA2 | ||||
| Protein Type | Enzyme | ||||
| Biological Properties | |||||
| General Function | Lipid transport and metabolism | ||||
| Specific Function | In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies. Also displays hydrolase activity on various fatty acyl-CoAs (By similarity). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (By similarity). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (By similarity). | ||||
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| Reactions |
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| GO Classification | Not Available | ||||
| Cellular Location | Not Available | ||||
| Gene Properties | |||||
| Chromosome Location | 24 | ||||
| Locus | Not Available | ||||
| SNPs | ACAA2 | ||||
| Gene Sequence |
>1194 bp ATGGCCCTGCTCCGAGGTGTGTTCATCGTCGCTGCTAAGCGGACCCCCTTTGGAGCTTAT GGGGGTCTTCTGAAAGACTTCACACCTACTGACATGGCTGAGTTTGCTGCCAGGGCTGCC TTGTCTGCTGGCAGAGTCTCACCGGAAACTGTCGACAGTGTCGTCGTAGGCAATGTCATG CAGAGTTCTTCAGATGCTATATACTTGGCAAGACATGTTGGTTTGCGTGTGGGAATCCCA AAAGAGACCCCAGCTATCACTATTAACAGGCTCTGTGGCTCTGGTTTCCAGTCCATTGTG AGTGGATGTCAGGAAATTTGTTCTAGAGACTCTGAAGTTGTCCTGTGTGGAGGAACTGAA AGCATGAGCCAGGCTCCCTACTGTGTCAGAAATATTCGTTTTGGAACTAAGCTTGGATCA GAGCTCAAGCTGGAAGACACTCTGTGGACAGGATTAACAGATACGCATGTCCAAATGCCG ATGGCAATTACTGCAGAGAATCTTGCTGTAAAACATCAAATAAGCAGAGAAGATTGTGAC AGATACGCCCTGCAATCACAGCAGAGGTGGAAAACTGCTAATGATGCTGGCTACTTTGAT AATGAGATGGCACCAGTTGAGGTGAAGACAAGGAAAGGAAAACAGACAATGCAAGTAGAT GAACATCCTCGGCCCCAAACAACCATGGAGCAGTTAAATAAACTTCCTCCAGTGTTCAAG AAAGAAGGAACCGTTACTGCAGGGAATGCGTCGGGGGTTTCCGATGGTGCTGGAGCTGTT ATCATAGCTAGTGAAGATGCTGTTAAAAAACATAACTTCACACCACTGGCAAGAATTGTG GGCTATTTTGTGTCTGGATGTGATCCCACTATCATGGGTATTGGTCCCGTCCCTGCTATC AGTGGAGCACTGAAGAAAACAGGGCTGAGTCTTAAGGATATGGATTTGGTAGAAGTGAAT GAAGCTTTTGCTCCTCAGTACTTGGCAGTTGAAAAGAGTTTGAATCTTGACCCAAGTAAG ACCAATGTGAATGGAGGGGCCATTGCTTTGGGTCACCCATTAGCAGGATCTGGGTCAAGA ATTACTGCACACCTGGTTCATGAATTAAGGCGTCGGGGTGGAAAATATGCTGTAGGATCA GCCTGCATTGGAGGTGGCCAAGGAATTGCGGTCATCATCGAGAACACAGCCTGA |
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| Protein Properties | |||||
| Number of Residues | 397 | ||||
| Molecular Weight | 42131.0 | ||||
| Theoretical pI | 8.01 | ||||
| Pfam Domain Function | Not Available | ||||
| Signals |
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| Transmembrane Regions | Not Available | ||||
| Protein Sequence |
>3-ketoacyl-CoA thiolase, mitochondrial MALLRGVFIVAAKRTPFGAYGGLLKDFTPTDMAEFAARAALSAGRVSPETVDSVVVGNVM QSSSDAIYLARHVGLRVGIPKETPAITINRLCGSGFQSIVSGCQEICSRDSEVVLCGGTE SMSQAPYCVRNIRFGTKLGSELKLEDTLWTGLTDTHVQMPMAITAENLAVKHQISREDCD RYALQSQQRWKTANDAGYFDNEMAPVEVKTRKGKQTMQVDEHPRPQTTMEQLNKLPPVFK KEGTVTAGNASGVSDGAGAVIIASEDAVKKHNFTPLARIVGYFVSGCDPTIMGIGPVPAI SGALKKTGLSLKDMDLVEVNEAFAPQYLAVEKSLNLDPSKTNVNGGAIALGHPLAGSGSR ITAHLVHELRRRGGKYAVGSACIGGGQGIAVIIENTA |
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| External Links | |||||
| GenBank ID Protein | ABU62844.1 | ||||
| UniProtKB/Swiss-Prot ID | Q3T0R7 | ||||
| UniProtKB/Swiss-Prot Entry Name | THIM_BOVIN | ||||
| PDB IDs | Not Available | ||||
| GenBank Gene ID | EF583004 | ||||
| GeneCard ID | ACAA2 | ||||
| GenAtlas ID | Not Available | ||||
| HGNC ID | Not Available | ||||
| References | |||||
| General References | Not Available | ||||