| Identification |
|---|
| BMDB Protein ID
| BMDBP00379 |
| Secondary Accession Numbers
| |
| Name
| Sepiapterin reductase |
| Synonyms
|
Not Available
|
| Gene Name
| SPR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin. |
| Pathways
|
Not Available
|
| Reactions
|
| Dyspropterin + NADP → NADPH + 1-hydroxy-2-Oxopropyl tetrahydropterin |
details
|
| Sepiapterin + NADPH → 7,8-Dihydroneopterin + NADP |
details
|
| 6-Lactoyltetrahydropterin + NADP → Tetrahydrobiopterin + NADPH |
details
|
| 6-Lactoyltetrahydropterin + NAD → 1-hydroxy-2-Oxopropyl tetrahydropterin + NADH |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| Not Available |
| SNPs
| SPR |
| Gene Sequence
|
>804 bp
ATGGAGGGCAGCGTCGGCAAGGTGGGCGGCCTGGGGCGCACCTTATGCGTGCTGACTGGG
GCTTCCCGGGGCTTCGGACGGACGCTGGCCCAAGTCCTGGCCCCGCTGATGTCGCCTCGC
TCCGTGCTGGTCCTAAGCGCCCGCAATGACGAGGCCCTGCGGCAGCTGGAGACCGAGCTG
GGCGCCGAGTGGCCGGGTCTGCGTATCGTGCGGGTGCCCGCCGACCTGGGCGCCGAGACC
GGCTTGCAGCAACTGGTCGGTGCTCTGTGCGACCTCCCCAGGCCCGAGGGCCTGCAGCGA
GTGCTGCTCATCAACAATGCGGGCACTCTTGGAGATGTATCCAAACGTTGGGTGGACCTG
ACTGACCCAACTGAAGTGAACAACTACTGGACTCTGAACTTGACTTCCACGCTCTGCCTG
ACTTCCAGTATCCTGCAGGCCTTCCCGGACAGTCCTGGCCTCAGCAGGACTGTGGTTAAC
ATCTCGTCCATCTGTGCCCTGCAGCCCTTCAAGGGCTGGGGACTGTACTGTGCTGGGAAG
GCTGCCCGTAACATGATGTTCCAGGTCCTGGCGGCGGAGGAACCTAGCGTGAGGGTGCTG
AGCTATGGCCCAGGTCCCCTGGACACTGACATGCAGCAGTTAGCCCGGGAGACCTCTGTG
GACCCAGACTTGCGAAAAAGCCTGCAGGAGCTGAAGAGAAAGGGGCAACTTGTGGATTGC
AAGATATCAGCCCAGAAACTTCTGAGCTTGCTGCAAAATGACAAGTTCGAGTCTGGAGCC
CATATTGACTTCTACGATGAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 267 |
| Molecular Weight
| 28939.0 |
| Theoretical pI
| 5.15 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Sepiapterin reductase
MEGSVGKVGGLGRTLCVLTGASRGFGRTLAQVLAPLMSPRSVLVLSARNDEALRQLETEL
GAEWPGLRIVRVPADLGAETGLQQLVGALCDLPRPEGLQRVLLINNAGTLGDVSKRWVDL
TDPTEVNNYWTLNLTSTLCLTSSILQAFPDSPGLSRTVVNISSICALQPFKGWGLYCAGK
AARNMMFQVLAAEEPSVRVLSYGPGPLDTDMQQLARETSVDPDLRKSLQELKRKGELVDC
KISAQKLLSLLQNDKFESGAHIDFYDE
|
| External Links |
|---|
| GenBank ID Protein
| ABI79460.1 |
| UniProtKB/Swiss-Prot ID
| Q17QK8 |
| UniProtKB/Swiss-Prot Entry Name
| SPRE_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| DQ978331 |
| GeneCard ID
| SPR |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
