| Identification |
|---|
| BMDB Protein ID
| BMDBP00410 |
| Secondary Accession Numbers
| |
| Name
| Acetylserotonin O-methyltransferase |
| Synonyms
|
Not Available
|
| Gene Name
| ASMT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Secondary metabolites biosynthesis, transport and catabolism |
| Specific Function
| Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). |
| Pathways
|
- Aromatic compound metabolism
- Melatonin biosynthesis
- Melatonin from serotonin: step 1/2
|
| Reactions
|
| 5-Hydroxyindoleacetic acid + S-Adenosylmethionine → 5-Methoxyindoleacetate + S-Adenosylhomocysteine |
details
|
| N-Acetylserotonin + S-Adenosylmethionine → Melatonin + S-Adenosylhomocysteine |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| Not Available |
| SNPs
| ASMT |
| Gene Sequence
|
>1053 bp
AGCCAGACCGGCCCAGAAGGAAGATGTGCTCCCAGGAGGGTGAGGGCTACAGTCTCCTGA
AGGAATACGCCAACGCGTTCATGGTCTCCCAGGTTCTCTTTGCTGCCTGTGAGCTGGGGG
TGTTTGAGCTCCTGGCAGAGGCCCTGGAGCCCCTGGACTCAGCAGCAGTGTCTTCACATC
TGGGCTCCAGCCCAGGGGACAGAGCTGCTACTGAACACCTGTGTGTCCCTGAAGCTGCTG
CAAGCCGACGTGAGGGGAGGAAAAGCTGTGTATGCAAACACGGAGCTCGCCAGCACCTAC
CTGGTGAGAGGCAGCCCCAGGTCCCAGCGGGACATGCTGCTGTACGCGGGCAGGACCGCT
TACGTCTGCTGGCGCCACCTGGCGAGGCAGTCAGGGAAGGGAGGAACCAGTATCTGAAAG
CCTTCGGGATCCCGTCCGAGGAGCTCTTCTCTGCCATCTACAGGTCTGAGGACGAAAGGC
TGCAGTTCATGCAGGGTCTGCAGGACGTGTGGAGGCTGGAGGGGGCGACGGTGCTGGCCG
CCTTCGACCTGTCCCCCTTCCCGCTCATCTGCGACCTGGGGGGCGGTTCTGGGGCTCTGG
CCAAGGCGTGCGTGTCCCTGTACCCGGGATGTCGGGCCATTGTGTTCGACATCCCAGGAG
TGGTGCAGATCGCCAAGAGACATTTCTCAGCCTCGGAGGACGAGCGCATCAGCTTCCATG
AAGGGGATTTCTTCAAAGACGCCCTCCCGGAGGCGGACCTGTATATCCTGGCCAGGGTCC
TGCATGACTGGACCGATGCCAAGTGCTCCCACCTGCTGCAGAGAGTCTATCGGGCCTGCA
GGACAGGTGGCGGCATCCTGGTCATCGAGAGCCTCCTGGACACGGACGGGCGGGGCCCTC
TGACCACGCTGCTGTACTCGCTGAACATGCTGGTGCAAACGGAGGGCCGTGAGCGGACCC
CCGGCCGAAGTACCGCGCGCTCCGTGGGCCCCGCCGCTTCCGAGACGTGCGGTGACGGAG
GACGGGGGGAACCTACGATGCTGTCTTGGCCAG
|
| Protein Properties |
|---|
| Number of Residues
| 345 |
| Molecular Weight
| 37924.0 |
| Theoretical pI
| 5.71 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Hydroxyindole O-methyltransferase
MCSQEGEGYSLLKEYANGFMVSQVLFAACELGVFELLAEALEPLDSAAVSSHLGSSPQGT
ELLLNTCVSLKLLQADVRGGKAVYANTELASTYLVRGSPRSQRDMLLYAGRTAYVCWRHL
AEAVREGRNQYLKAFGIPSEELFSAIYRSEDERLQFMQGLQDVWRLEGATVLAAFDLSPF
PLICDLGGGSGALAKACVSLYPGCRAIVFDIPGVVQIAKRHFSASEDERISFHEGDFFKD
ALPEADLYILARVLHDWTDAKCSHLLQRVYRACRTGGGILVIESLLDTDGRGPLTTLLYS
LNMLVQTEGRERTPAEYRALLGPAGFRDVRCRRTGGTYDAVLARK
|
| External Links |
|---|
| GenBank ID Protein
| AAA30565.1 |
| UniProtKB/Swiss-Prot ID
| P10950 |
| UniProtKB/Swiss-Prot Entry Name
| ASMT_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| J02671 |
| GeneCard ID
| ASMT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
