| Identification |
|---|
| BMDB Protein ID
| BMDBP00477 |
| Secondary Accession Numbers
| None |
| Name
| Bis(5'-adenosyl)-triphosphatase |
| Synonyms
|
Not Available
|
| Gene Name
| FHIT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity. Functions as tumor suppressor (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| Not Available |
| SNPs
| FHIT |
| Gene Sequence
|
>450 bp
ATGTCGTTCAGATTTGGCCAACATCTCATCAAGCCCTCGGTGGTGTTTCTCAAAACAGAA
CTGTCCTTTGCCCTGGTGAACAGGAAGCCTGTGGTACCTGGACATGTCCTCGTGTGTCCC
CTCCGGCCAGTGGAGCGCTTCCGAGACATGAGTCCTGAAGAAGTGGCTGACTTGTTTCAG
GCAGCACAGAGAGTCGGCACGGTGGTAGAGAAGCATTTCCAGGGCACCTCGCTCACGTTT
TCCATGCAGGATGGCCCCGAAGCCGGACAGACTGTGAAGCATGTTCACGTCCACATTCTT
CCAAGGAAGGCTGGAGACTTTCACAGGAATGACAGCATCTATGATGCGCTCGAGAAACAC
GACAGAGAGGATAAAGACTCCCCAGCCTTGTGGCGGTCAGAGGAGGAAATGGCAGCTGAG
GCTGCAGCGCTGAGGGTCTACTTTCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 149 |
| Molecular Weight
| 16951.0 |
| Theoretical pI
| 6.97 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Bis(5'-adenosyl)-triphosphatase
MSFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFRDMSPEEVADLFQ
AAQRVGTVVEKHFQGTSLTFSMQDGPEAGQTVKHVHVHILPRKAGDFHRNDSIYDALEKH
DREDKDSPALWRSEEEMAAEAAALRVYFQ
|
| External Links |
|---|
| GenBank ID Protein
| ABC61315.1 |
| UniProtKB/Swiss-Prot ID
| Q1KZG4 |
| UniProtKB/Swiss-Prot Entry Name
| FHIT_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| DQ335870 |
| GeneCard ID
| FHIT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
