| Identification |
|---|
| BMDB Protein ID
| BMDBP00507 |
| Secondary Accession Numbers
| None |
| Name
| Nucleoside diphosphate kinase B |
| Synonyms
|
Not Available
|
| Gene Name
| NME2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (By similarity). Exhibits histidine protein kinase activity (PubMed:12486123). |
| Pathways
|
|
| Reactions
|
| Adenosine triphosphate + Uridine 5'-diphosphate → ADP + Uridine triphosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| NME2 |
| Gene Sequence
|
>459 bp
ATGGCCCACGCGGAGCGCACCTTTATTGCTATCAAGCCGGACGGCGTGCAGCGCGGCCTG
GTGGGCGAGATCATCAAGCGCTTCGAGCAGAAGGGATTCCGCCTTGTGGCCATGAAGTTC
CTTCAGGCCTCTGAGGAACTCCTGAAGCAGCACTACATTGACCTGAAAGACCGCCCATTC
TTTCCCGGCCTGGTGAAGTACATGAACTCAGGGCCAGTTGTGGCCATGGTCTGGGAGGGC
CTGAATGTAGTGAAGACAGGACGAGTGATGCTTGGGGAGACCAACCCAGCAGATTCTAAG
CCGGGCACCATTCGTGGTGACTTCTGCATTCAAGTTGGCAGGAACATCATTCATGGCAGT
GATTCAGTAAAAAGTGCTGAGAAAGAGATCAACTTGTGGTTTAAGCCCGAAGAATTGATT
GAATACAAGCCTTGTGCTTTTGACTGGATATATGAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 152 |
| Molecular Weight
| 17316.0 |
| Theoretical pI
| 8.22 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Nucleoside diphosphate kinase B
MAHAERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLQASEELLKQHYIDLKDRPF
FPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGS
DSVKSAEKEINLWFKPEELIEYKPCAFDWIYE
|
| External Links |
|---|
| GenBank ID Protein
| AAI02301.1 |
| UniProtKB/Swiss-Prot ID
| Q3T0Q4 |
| UniProtKB/Swiss-Prot Entry Name
| NDKB_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC102300 |
| GeneCard ID
| NME2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
