Showing Protein Acyl-coenzyme A synthetase ACSM1, mitochondrial (BMDBP00509)
| Identification | |||
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| BMDB Protein ID | BMDBP00509 | ||
| Secondary Accession Numbers |
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| Name | Acyl-coenzyme A synthetase ACSM1, mitochondrial | ||
| Synonyms | Not Available | ||
| Gene Name | ACSM1 | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Lipid transport and metabolism | ||
| Specific Function | Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:11382754, PubMed:10561077). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:10561077, PubMed:11382754). Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (PubMed:11382754). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (PubMed:11382754). | ||
| Pathways | Not Available | ||
| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 25 | ||
| Locus | Not Available | ||
| SNPs | ACSM1 | ||
| Gene Sequence |
>1734 bp ATGCAAAGGCTGATGAAGTTTCGGGTCCTCTGGGGCATCCACATGTCCTGCCCTGGCTTC CACCATGCCCCTCAGCACCTGCGCTGCCGATCTTTATCAGGAGCTGGAACCCTAAGATGG AATGACTATGACAGACCTGAGGAATTTAACTTTGCAAGTGATGTACTGGACCACTGGACT CAAATGGAGAAGGAGGGCAAGAGAAGTCCAAACCCAGCCCTGTGGTGGGTGAACGATCAA GGGGATGAAGTGAAGTGGAGCTTCAGAGAGATGACAGACTTAACCTGTCGCACAGCCAAC GTCCTGACACAGACCTGCGGCCTTCAGACGGGAGACCGTCTAGCGTTGATTTTGCCTCGA GTGCCTGAGTGGTGGCTTGTGTGTGTGGGCTGCATCCGAACAGGGATCATCTTCATGCCA GGGACCACCCAGATGAAGGCCAAGGACATTCTCTACCGACTACAAGTATCTGGAGCCAAA GCCATCGTGACCACAGATACCCTTGCCCCAGAGGTGGAGTCTGTGGCACCTGAGTGTCCT TCTCTGAAAACCAAGCTCCTGGTGTCTGACCACAGCCGTGAAGGGTGGCTGGACTTCCGA TCACTGGTTAAATCAGCCTCCCCAGATCACATCTGTATTAAGTCAAAGACCCTGGACCCA ATGGCCATCTTCTTCACCAGTGGGACCACGGGCTTCCCCAAGATGGCAAAGCACAGCCAC GGATTCGCTTTACGATCCTATTTCCCAGCATGCAGGAAATTGTTGCAGCTGAAGATGTCT GATGTCTTCTGGTGCCTGTCAGACACAGGCTGGATTCTGGCTGCCTTGGGGTCCCTGCTT GAACCATGGACAGCGGGGTCTACAGTCTTTGCTCATCATCTGCCTCAGTTTGACCCTAAG GTCATTATAGAGACATTTTTCAAATATCCAATTACCCAATGCCTTGCTGCACCTTCTGTA TATCGAATGATTTTGCAGCAGAATTACACCAGTCTTAGGTTCCCCACTCTGGAACACTGC TGTACTGGTGGGGAAGCCCTGCTGCCCGAGGAGCAAGAACAGTGGAAAAGACAGACAGGT GTTCTGCTCTACCAGGCCTATGGACAGTCAGAAACGGGAATAAGCTGTGGCACTCTCCGG GGGATGAAGATCAAGCCAGGTTCCATGGGGAAGGCCATCCCACCCTTTGACATTCAGATC ATTGATGACAAGGGCAATATCCAGCCTCCCAACACGGAAGGAAACATTGGCATCAGGATC AAGCCCACCAGGCCCATAGGCCTCTTCATGTACTATGAGAATAACCCAGAGAAAACAGCT GAAGTGGAATGTGGGGACTTTTATAACACTGGGGACAGAGCAACTATTGACGAAGAGGGC TACTTCTGGTTCCTTGGGAGGAGTGACGATGTCATCAATGCATCCGGATACCGCGTTGGG CCAGCAGAAGTAGAGAATGCCCTGGCAGAGCACCCAGCGGTGGCTGAGTCTGCTGTGGTG AGCAGCCCGGACCCGGTTCGAGGGGAGGTAGTGAAGGCATTTATTGTCCTGAACCCGGAA TTCTCGAGCCGTGACCCAGGCGAGCTCACCAAGGAGCTGCAGCAGCATGTCAAGTCAGTG ACAGCCCCATACAAGTACCCGAGGAAGGTGGAGTTTGTCTCAGAGCTGCCCAAAACCATC ACTGGCAAGATAAAGAGAAGTGAGCTTCGGAAGAAGGAGTTTGGTCAGAAGTAG |
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| Protein Properties | |||
| Number of Residues | 577 | ||
| Molecular Weight | 64923.0 | ||
| Theoretical pI | 7.79 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>Acyl-coenzyme A synthetase ACSM1, mitochondrial MQRLMKFRVLWGIHMSCPGFHHAPQHLRCRSLSGAGTLRWNDYDRPEEFNFASDVLDHWT QMEKEGKRSPNPALWWVNDQGDEVKWSFREMTDLTCRTANVLTQTCGLQTGDRLALILPR VPEWWLVCVGCIRTGIIFMPGTTQMKAKDILYRLQVSGAKAIVTTDTLAPEVESVAPECP SLKTKLLVSDHSREGWLDFRSLVKSASPDHICIKSKTLDPMAIFFTSGTTGFPKMAKHSH GFALRSYFPACRKLLQLKMSDVFWCLSDTGWILAALGSLLEPWTAGSTVFAHHLPQFDPK VIIETFFKYPITQCLAAPSVYRMILQQNYTSLRFPTLEHCCTGGEALLPEEQEQWKRQTG VLLYQAYGQSETGISCGTLRGMKIKPGSMGKAIPPFDIQIIDDKGNIQPPNTEGNIGIRI KPTRPIGLFMYYENNPEKTAEVECGDFYNTGDRATIDEEGYFWFLGRSDDVINASGYRVG PAEVENALAEHPAVAESAVVSSPDPVRGEVVKAFIVLNPEFSSRDPGELTKELQQHVKSV TAPYKYPRKVEFVSELPKTITGKIKRSELRKKEFGQK |
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| External Links | |||
| GenBank ID Protein | AAD39140.1 | ||
| UniProtKB/Swiss-Prot ID | Q9BEA2 | ||
| UniProtKB/Swiss-Prot Entry Name | ACSM1_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | AF126145 | ||
| GeneCard ID | ACSM1 | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||