Showing Protein Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (BMDBP00521)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP00521 |
| Secondary Accession Numbers | None |
| Name | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial |
| Synonyms | Not Available |
| Gene Name | IDH3A |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Energy production and conversion |
| Specific Function | Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 21 |
| Locus | Not Available |
| SNPs | IDH3A |
| Gene Sequence |
>1101 bp ATGGCAGGGCCCGCGTGGATCTCCAAGGTCTCTCGGCTGCTGGGGGCATTCCACAACCAA AAACAGGTGACCAGAGGTTTTGCTGGTGGTGTTAAGACAGTAACTTTAATTCCAGGAGAT GGAATTGGCCCAGAAATTTCTGCTGCAGTTATGAAGATTTTTGATGCTGCCAAAGCACCT ATTCAGTGGGAGGAGCGAAACGTCGCCGCCATTCAAGGTCCGGGAGGCAAGTGGATGATC CCTCCAGAAGCCAAAGAGTCCATGGATAAGAACAAGATGGGCTTGAAAGGCCCTTTAAAA ACACCAATAGCTGCTGGTCACCCATCTATGAATTTATTGCTGCGTAAAACATTTGACCTT TATGCAAATGTCCGACCATGTGTCTCAATCGAAGGCTATAAAACCCCTTACCATGATGTA AATATTGTCACCATTCGAGAGAACACGGAAGGAGAATACAGTGGAATCGAGCATGTGATC GTGGATGGAGTTGTGCAGAGTATCAAGCTCATCACCGAGGCAGCGAGCAAGCGCATCGCG GAGTTTGCATTTGAATACGCACGGAACAACCACCGGAGCAACGTCACAGCCGTGCACAAA GCCAACATCATGCGAATGTCAGATGGGCTTTTTCTGCAAAAATGCAGGGAAGTTGCAGAA AACTGTAAAGATATTAAATTTAATGAGATGTACCTTGATACAGTATGTTTGAATATGGTC CAAGACCCGTCCCAGTTTGATGTTCTTGTTATGCCAAATTTGTATGGAGACATCCTTAGT GACCTGTGTGCGGGATTGATTGGAGGTCTTGGTGTGACACCAAGCGGCAACATTGGAGCC AACGGAGTTGCAATCTTCGAGTCGGTTCACGGGACCGCCCCGGACATTGCGGGCAAGGAC ATGGCCAATCCCACAGCCCTCCTGCTCAGCGCCGTGATGATGCTGCGCCACATGGGGCTT TTTGACCACGCTGCGAAGATTGAGACGGCGTGTTTTGCTACAATTAAGGATGGAAAGAGC TTAACCAAAGATTTGGGAGGCAATTCAAAGTGCTCGGACTTCACAGAAGAAATCTGTCGC CGAGTAAAAGATTTAGATTAA |
| Protein Properties | |
| Number of Residues | 366 |
| Molecular Weight | 39668.0 |
| Theoretical pI | 7.22 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial MAGPAWISKVSRLLGAFHNQKQVTRGFAGGVKTVTLIPGDGIGPEISAAVMKIFDAAKAP IQWEERNVAAIQGPGGKWMIPPEAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDL YANVRPCVSIEGYKTPYHDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEAASKRIA EFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMV QDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKD MANPTALLLSAVMMLRHMGLFDHAAKIETACFATIKDGKSLTKDLGGNSKCSDFTEEICR RVKDLD |
| External Links | |
| GenBank ID Protein | AAC18425.1 |
| UniProtKB/Swiss-Prot ID | P41563 |
| UniProtKB/Swiss-Prot Entry Name | IDH3A_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | U07980 |
| GeneCard ID | IDH3A |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |