Showing Protein Arachidonate 15-lipoxygenase (BMDBP00685)
| Identification | |||||||||
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| BMDB Protein ID | BMDBP00685 | ||||||||
| Secondary Accession Numbers |
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| Name | Arachidonate 15-lipoxygenase | ||||||||
| Synonyms | Not Available | ||||||||
| Gene Name | ALOX15 | ||||||||
| Protein Type | Enzyme | ||||||||
| Biological Properties | |||||||||
| General Function | Involved in arachidonate 12-lipoxygenase activity | ||||||||
| Specific Function | Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass. | ||||||||
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| GO Classification | Not Available | ||||||||
| Cellular Location | Not Available | ||||||||
| Gene Properties | |||||||||
| Chromosome Location | 19 | ||||||||
| Locus | Not Available | ||||||||
| SNPs | ALOX15 | ||||||||
| Gene Sequence |
>1992 bp ATGGGTCTCTACCGCGTCCGCGTGTCCACCGGGTCCTCGTTCTGCGCGGGCTCCAATAAC CAGGTGCACCTGTGGCTGGTCGGCGAGCACGGGGAGGCGGCGCTCGGGTGGGCCGTGCGG CCGGCGAGGGGGAAGGAGGTGGAATTCCAGGTGGACGTGTCCGAGTACCTGGGGCGGCTG CTGTTCGTGAAATTGCGCAAACGGCACCTCCTCTCGGATGATGCGTGGTTCTGCAACTGG ATCTCCGTGCAGGGCCCCGGGGCCAGTGGGAACGAGTTCAGGTTCCCGTGCTATCGCTGG GTGGAGGGCGATGGCATCCTGAGCCTGCCCGAGGGCACCGGTCGCACTGTGGTCGATGAC CCTCAAGGTCTGTTCAAGAAACACAGGGAAGAGGAGCTGGCAGAGAGAAGGAAGCTGTAC CGGTGGGGTAACTGGAAGGACGGGTTAATTCTGAATATAGCTGGGGCCACAATAAATGAC CTTCCTGTAGATGAGAGATTTCTAGAGGACAAAAGAATTGACTTTGAGGCCTCACTGACC AAGGGGCTGGCAGACCTAGCCATCAAAGACTCTTTAAACATTCTGACTTGCTGGAAAAGT CTGGATGACTTCAACAGGATTTTCTGGTGTGGCCAGAGCAAGCTGGCTGAGCGGGTGCGG GATTCCTGGAAGGAGGATGCCTTATTTGGGTACCAGTTTCTCAACGGCACCAACCCCATG TTGCTGAGACGCTCCGTTCGCCTTCCTGCCCGCCTGGAGTTTCCTCCAGGGATGGGGGAG CTGCAGGCCGAGCTGGAGAAGGAGCTCCAGCAAGGCACGCTATTTGAAGCTGACTTCTCC TTGCTGATGGGGATCAAGGCCAACGTCATCCTGTGTACCCAGCAGTATGTGGCTGCCCCT CTGGTTATGCTGAAACTGCAGCCCGATGGGAAACTCTTACCCATGGCCATCCAGCTCCAA CTGCCACACAAGGGGTCCCCACCACCACCGCTTTTCCTGCCCACGGATCCCCCGATGACC TGGCTCCTGGCCAAATGCTGGGTCCGGAGCTCTGACTTCCAGCTTCACGAGCTGCACTCT CATCTCCTGAGGGGACACTTGGTGGCTGAGGTCATCGCTGTGGCCACCATGAGGTGCCTT CCGTCTATACATCCTATGTTCAAGCTTCTCATTCCGCACCTGCGATACACCATGGAAATT AACATCCGGGCCAGGACTGGGCTGGTCTCTGACTCGGGAGTCTTCGACCAGGTGGTGAGC ACAGGTGGGGGCGGCCATGTGGAGCTGCTCCAGCGAGCAGGAGCCTTTCTAACCTATAGC TCCTTCTGTCCCCCTGATGACCTGGCTGACCGGGGGCTCCTGGGAGTCAAGTCTTCTTTC TATGCCCAAGATGCCCTGAGGCTCTGGGAAATTCTCTCTCGCTACGTGGAGGGGATTGTG AGTCTCCACTATAAGACGGACGAGTCTGTGAGAGACGACATTGAGCTGCAGGCCTGGTGT CGAGATATCACTGAGATTGGGCTGCTGGGTGCCCAGGACCGAGGGTTTCCCGTCACCCTA CAGTCCAAGGACCAGCTTTGCCACTTTGTGACCATGTGTATCTTCACCTGCACTGGTCAG CACTCCTCCACTCACCTGGGCCAGCTGGACTGGTACTCTTGGGTCCCTAACGCACCCTGC ACAATGCGGCTGCCCCCACCGACCACCAAGGATGTGACACTGGAGAAAGTGATGGCAACA CTGCCGAACTTCCATCAGGCTTCTCTCCAGATGTCCATCACTTGGCAACTGGGCAGACGC CAGCCCATCATGGTGGCTCTGGGTCAGCATGAGGAAGAGTACTTCTCAGGCCCTGAGCCC AAGGCTGTGCTAAAGAAGTTCAGGGAGGAGCTGGCTGCCCTGGAAAAAGACATAGAGATC CGGAATGCCCAGCTGGACTGGCCCTACGAATACCTGCGGCCCAGCCTGGTGGAAAACAGC GTGGCCATATGA |
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| Protein Properties | |||||||||
| Number of Residues | 663 | ||||||||
| Molecular Weight | 75124.0 | ||||||||
| Theoretical pI | 6.51 | ||||||||
| Pfam Domain Function | Not Available | ||||||||
| Signals |
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| Transmembrane Regions | Not Available | ||||||||
| Protein Sequence |
>Arachidonate 12-lipoxygenase, 12S-type MGLYRVRVSTGSSFCAGSNNQVHLWLVGEHGEAALGWAVRPARGKEVEFQVDVSEYLGRL LFVKLRKRHLLSDDAWFCNWISVQGPGASGNEFRFPCYRWVEGDGILSLPEGTGRTVVDD PQGLFKKHREEELAERRKLYRWGNWKDGLILNIAGATINDLPVDERFLEDKRIDFEASLT KGLADLAIKDSLNILTCWKSLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGTNPM LLRRSVRLPARLEFPPGMGELQAELEKELQQGTLFEADFSLLMGIKANVILCTQQYVAAP LVMLKLQPDGKLLPMAIQLQLPHKGSPPPPLFLPTDPPMTWLLAKCWVRSSDFQLHELHS HLLRGHLVAEVIAVATMRCLPSIHPMFKLLIPHLRYTMEINIRARTGLVSDSGVFDQVVS TGGGGHVELLQRAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEILSRYVEGIV SLHYKTDESVRDDIELQAWCRDITEIGLLGAQDRGFPVTLQSKDQLCHFVTMCIFTCTGQ HSSTHLGQLDWYSWVPNAPCTMRLPPPTTKDVTLEKVMATLPNFHQASLQMSITWQLGRR QPIMVALGQHEEEYFSGPEPKAVLKKFREELAALEKDIEIRNAQLDWPYEYLRPSLVENS VAI |
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| External Links | |||||||||
| GenBank ID Protein | AAC41614.1 | ||||||||
| UniProtKB/Swiss-Prot ID | P27479 | ||||||||
| UniProtKB/Swiss-Prot Entry Name | LOX15_BOVIN | ||||||||
| PDB IDs | Not Available | ||||||||
| GenBank Gene ID | M62516 | ||||||||
| GeneCard ID | ALOX15 | ||||||||
| GenAtlas ID | Not Available | ||||||||
| HGNC ID | Not Available | ||||||||
| References | |||||||||
| General References | Not Available | ||||||||