Showing Protein Cytosolic phospholipase A2 (BMDBP00783)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 7 metabolites
Identification
BMDB Protein ID BMDBP00783
Secondary Accession Numbers
  • BMDBP03035
Name Cytosolic phospholipase A2
Synonyms Not Available
Gene Name PLA2G4A
Protein Type Enzyme
Biological Properties
General Function Involved in calcium ion binding
Specific Function Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (By similarity). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (By similarity). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway. In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophopholipids to release free bioactive eicosanoids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific. Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides. Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (By similarity).
Pathways Not Available
Reactions
PC(14:0/20:4(5Z,8Z,11Z,14Z)) + Water → Arachidonic acid + LysoPC(14:0) details
PE(16:0/16:0) → LysoPE(16:0/0:0) details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 16
Locus Not Available
SNPs PLA2G4A
Gene Sequence 
>2250 bp
ATGTCATTTATAGATCCTTATCAACACATTATAGTGGAGCACCATTATTCCCACAAGTTC
ACAGTAGTGGTGCTGCGTGCCACAAAAGTGACAAAGGGAACCTTTGGTGACATGCTTGAC
ACTCCAGACCCCTATGTGGAACTTTTCATCTCTTCAACCCCCGACAGCAGGAAGAGAACA
AGACACTTCAATAATGACATAAACCCTGTGTGGAATGAGACCTTTGAATTTATTTTGGAT
CCTAATCAGGAAAATATTTTGGAGATCACTTTAATGGATGCCAATTATGTTATGGATGAA
ACTCTTGGGACGACAACGTTTCCCATATCTTCTATGAAAGTGGGAGAGAAGAAACAGGTT
CCTTTTATTTTCAATCAAGTCACTGAAATGATTCTGGAAATGTCTCTTGAAGTTTGTTCA
TCCCCAGACCTCCGGTTTAGTATGGCTCTGTGTGACCAGGAGAAAGCTTTCAGACAACAG
AGAAAGGAAAACATAAAGGAAAACATGAAGAAACTGCTGGGTCCAAAGAATAGTGAAGGC
TTGCATTCTACACGTGATGTGCCTGTGGTGGCCATACTGGGCTCAGGTGGGGGATTTCGA
GCCATGGTAGGATTCTCTGGTGTGATGAAGGCACTGTATGAGTCAGGGATTTTGGACTGT
GCTACCTACATTGCTGGTCTTTCTGGATCCACATGGTATATGTCGACCTTATATTCTCAC
CCTGATTTTCCAGAGAAAGGGCCAGAGGAGATTAACAAAGAGCTAATGAAAAATGTCAGC
CACAACCCTCTTTTACTTCTCACACCACAGAAAATTAAAAGATATGTTGAGTCTTTATGG
AGGAAAAAAAGTTCTGGACAACCTGTCACCTTTACTGATATCTTCGGGATGTTAATAGGA
GAAACACTAATTCACAATAGAATGAACACTACCCTGAGTAGTTTGAAGGAAAAAGTCAAT
ACTGGGCAGTGTCCTCTGCCGCTTTTCACCTGTCTCCATGTCAAACCCGATGTCTCAGAG
CTGATGTTTGCAGATTGGGTTGAATTTAGTCCATTTGAGATTGGCATGGCTAAATATGGT
ACTTTTATGGCGCCTGACTTATTTGGAAGCAAATTTTTTATGGGAACAGTTGTAAAGAAA
TACGAAGAAAACCCCTTGCATTTCTTAATGGGTGTCTGGGGTAGTGCCTTTTCTATATTG
TTCAACAGAGTCTTGGGAGTTTCTGGATCACAAAGTAAAGGTTCCACAATGGAAGAAGAA
CTAGAAAATATTACAGCAAAGCATATTGTGAGTAATGATAGCTCAGACAGTGATGACGAA
TCACAAGGACCCAAAGGCACTGAACATGAAGAAGCAGAAAGGGAATACCAAAATGATAAT
CAAGCAAGTTGGGTCCAACGTATGCTCATGGCCTTGGTGAGTGACTCAGCTTTGTTCAAT
ACCAGAGAAGGACGTGCCGGGAAGGTGCACAACTTCATGCTGGGCTTGAATCTCAATACA
TCCTATCCAATGTCTCCTTTGAGAGACTTTACCATGCAAGAGTCCCTGGATGAAGACGAA
TTGGATGCCGCTGTCGCAGATCCTGATGAATTTGAGCAGATATATGAGCCTTTGGATGTC
AAAAGTAAAAAGATTCATGTGGTGGACAGTGGCCTCACATTTAACCTTCCATACCCTTTG
ATCCTGAGACCTCAGAGGGGAGTTGATCTCATCATCTCCTTTGACTTTTCTGCAAGACCA
GGTGACTCCAGTCCTCCGTTCAAGGAACTTCTACTTGCAGAAAAGTGGGCTAAAATGAAC
AAGCTCCCCTTTCCAAAGATTGATCCTTACGTATTCGATCGAGAAGGACTGAAGGAATGC
TATGTTTTTAAACCCAAGAATCCTGATGTCGAGAAAGATTGCCCGACTATCATTCACTTT
GTTCTGGCCAACATCAACTTCAGAAAGTACAAGGCTCCAGGTGTTCCAAGAGAAACTAAT
GAAGAGAAAGAAATAGCTGATTTTGATATTTTTGATGACCCTGAATCACCGTTTTCGACC
TTCAACTTTCAATATCCCAATCAAGCATTTAAAAGGCTGCATGATCTCATGTACTTCAAT
ACCCTGAACAACATTGATGTAATAAAGAATGCTATAGTCGAAAGCATCGAATATAGAAGG
CAGAATCCGTCTCGTTGCTCTGTTTCCCTCAGTAGTGTTGAGGCAAGAAGATTCTTCAAC
AAGGAGTTTCTAAGCAAACCCACAGCATAG
Protein Properties
Number of Residues 749
Molecular Weight 85350.0
Theoretical pI 5.18
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • 12-31
  • 67-88
  • 100-117
  • 137-158
  • 170-198
  • 204-222
Protein Sequence 
>Cytosolic phospholipase A2
MSFIDPYQHIIVEHHYSHKFTVVVLRATKVTKGTFGDMLDTPDPYVELFISSTPDSRKRT
RHFNNDINPVWNETFEFILDPNQENILEITLMDANYVMDETLGTTTFPISSMKVGEKKQV
PFIFNQVTEMILEMSLEVCSSPDLRFSMALCDQEKAFRQQRKENIKENMKKLLGPKNSEG
LHSTRDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYIAGLSGSTWYMSTLYSH
PDFPEKGPEEINKELMKNVSHNPLLLLTPQKIKRYVESLWRKKSSGQPVTFTDIFGMLIG
ETLIHNRMNTTLSSLKEKVNTGQCPLPLFTCLHVKPDVSELMFADWVEFSPFEIGMAKYG
TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSKGSTMEEE
LENITAKHIVSNDSSDSDDESQGPKGTEHEEAEREYQNDNQASWVQRMLMALVSDSALFN
TREGRAGKVHNFMLGLNLNTSYPMSPLRDFTMQESLDEDELDAAVADPDEFEQIYEPLDV
KSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMN
KLPFPKIDPYVFDREGLKECYVFKPKNPDVEKDCPTIIHFVLANINFRKYKAPGVPRETN
EEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMYFNTLNNIDVIKNAIVESIEYRR
QNPSRCSVSLSSVEARRFFNKEFLSKPTA
GenBank ID Protein AAR17479.1
UniProtKB/Swiss-Prot ID A4IFJ5
UniProtKB/Swiss-Prot Entry Name PA24A_BOVIN
PDB IDs
GenBank Gene ID AY363688
GeneCard ID PLA2G4A
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available