| Identification |
|---|
| BMDB Protein ID
| BMDBP00839 |
| Secondary Accession Numbers
| |
| Name
| Adenosine deaminase |
| Synonyms
|
Not Available
|
| Gene Name
| ADA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (By similarity). Plays an important role in purine metabolism and in adenosine homeostasis (By similarity). Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events (By similarity). Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (PubMed:23240012). Enhances CD4+ T-cell differentiation and proliferation (By similarity). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (By similarity). Stimulates plasminogen activation (By similarity). Plays a role in male fertility (By similarity). Plays a protective role in early postimplantation embryonic development (By similarity). |
| Pathways
|
Not Available
|
| Reactions
|
| Adenosine + Water → Inosine + Ammonia |
details
|
| Deoxyadenosine + Water → Deoxyinosine + Ammonia |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| Not Available |
| SNPs
| ADA |
| Gene Sequence
|
>1092 bp
ATGGCCCAGACGCCCGCCTTCAACAAGCCCAAAGTAGAACTGCATGTCCACCTGGATGGA
GCCATCAAGCCCGAAACCATCTTATATTATGGCAGGAAGAGGGGCATCGCCCTCCCCGCC
GACACGCCAGAGGAGCTACAGAACATCATCGGCATGGACAAGCCACTTAGCCTCCCAGAG
TTCCTGGCCAAGTTCGACTACTACATGCCTGCCATTGCGGGCTGCCGGGAGGCTGTCAAA
AGGATTGCCTACGAGTTTGTGGAGATGAAGGCCAAGGACGGCGTGGTGTATGTGGAGGTG
CGCTACAGCCCACACCTGCTGGCCAACTCCAAGGTGGAGCCGATCCCCTGGAACCAGGCT
GAAGGGGACCTCACCCCGGATGAGGTGGTGTCACTGGTGAACCAGGGCCTGCAGGAGGGG
GAGCGGGACTTCGGCGTGAAGGTGCGGTCCATCCTGTGCTGCATGCGCCACCAGCCCAGC
TGGTCCTCTGAGGTGGTGGAGCTGTGTAAGAAGTACCGAGAGCAGACCGTGGTGGCCATT
GACCTGGCTGGAGATGAGACCATTGAAGGCAGCAGCCTCTTCCCTGGACATGTGAAGGCC
TATGCGGAGGCCGTGAAGAGCGGCGTCCACCGCACGGTCCACGCCGGGGAAGTGGGCTCG
GCCAATGTGGTGAAAGAGGCCGTGGACACACTCAAGACCGAGAGGCTGGGGCATGGCTAC
CACACCCTGGAGGATGCCACCCTTTACAACAGGCTGCGGCAGGAAAACATGCACTTCGAG
GTCTGCCCCTGGTCCAGCTACCTCACCGGCGCCTGGAAGCCCGACACGGAACACCCGGTT
GTTCGGTTCAAAAACGACCAGGTTAACTACTCGCTCAACACGGATGACCCGCTCATCTTC
AAGTCCACGCTGGACACGGATTACCAGATGACCAAGAATGAAATGGGCTTCACCGAAGAG
GAGTTTAAGAGACTGAACATCAATGCGGCCAAGTCCAGTTTCCTCCCTGAAGATGAGAAG
AAGGAGCTTCTTGATCTGCTCTATAAGGCCTACGGGATGCCCTCTCCGGCCTCTGCAGAG
CAGTGTCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 363 |
| Molecular Weight
| 40919.0 |
| Theoretical pI
| 5.2 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Adenosine deaminase
MAQTPAFNKPKVELHVHLDGAIKPETILYYGRKRGIALPADTPEELQNIIGMDKPLSLPE
FLAKFDYYMPAIAGCREAVKRIAYEFVEMKAKDGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVSLVNQGLQEGERDFGVKVRSILCCMRHQPSWSSEVVELCKKYREQTVVAI
DLAGDETIEGSSLFPGHVKAYAEAVKSGVHRTVHAGEVGSANVVKEAVDTLKTERLGHGY
HTLEDATLYNRLRQENMHFEVCPWSSYLTGAWKPDTEHPVVRFKNDQVNYSLNTDDPLIF
KSTLDTDYQMTKNEMGFTEEEFKRLNINAAKSSFLPEDEKKELLDLLYKAYGMPSPASAE
QCL
|
| External Links |
|---|
| GenBank ID Protein
| AAF91430.1 |
| UniProtKB/Swiss-Prot ID
| P56658 |
| UniProtKB/Swiss-Prot Entry Name
| ADA_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| AF280603 |
| GeneCard ID
| ADA |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
