| Identification |
|---|
| BMDB Protein ID
| BMDBP00849 |
| Secondary Accession Numbers
| None |
| Name
| UDP-glucuronosyltransferase 3A1 |
| Synonyms
|
Not Available
|
| Gene Name
| UGT3A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Carbohydrate transport and metabolism |
| Specific Function
| UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). |
| Pathways
|
- Androgen and Estrogen Metabolism
- Porphyrin Metabolism
- Retinol Metabolism
- Sphingolipid Metabolism
- Starch and Sucrose Metabolism
|
| Reactions
|
| Ceramide (d18:1/18:0) → Galactosylceramide (d18:1/16:0) |
details
|
| Testosterone → Testosterone glucuronide |
details
|
| Uridine diphosphate glucuronic acid → Isovalerylglucuronide + Uridine 5'-diphosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 20 |
| Locus
| Not Available |
| SNPs
| UGT3A1 |
| Gene Sequence
|
>1572 bp
ATGGCAGGGCAGCAGGCACTGCTTCTATTTGGATTTATACTGCCTGGGCTCCTGTTTTCA
GAGGCTGCCAAAATCCTAACTGTGTCCCTGGTGGGTGGAAGCCATTTTCTACTGATGCAT
CAGATCTCTCAGATTCTTCAAGATCATGGTCATAATGTCACCATGCTTCTCCAAAAGGGA
AATTTATTGCTACCAGGTTTTAAAGAGGAGGAGAAATCATACAAAGTTTTTAACTGGTTT
CTGCCTGAAGACTGTAATGAAGAATTTAAGAGGTCTTTTCATTCCTTTATGGAGAAAACT
TTTGGGGGCAGATGCAAATTTGAACACTTTTTAAATATTATGGAACTACTAGGGCATCAC
TGCAGTCATTTGCTAAGGAGAAAGGATGTCATGAAGTCTTTAAAGAATGAGAACTTCGAC
CTGGTGATAGTGGAAATGTTTGACTACTGTCCTTTCTTGGTTGCTGAGAAGCTTGGGAAG
CCATTTGTGGCCATTCTCCCTTCCGCACTGGGCACCGTGGACTTTGGGCTACCAAGCCCT
CTGTCTTATGTGCCAGTGTTCTACTCCTTGTTAACGGACCAGATGGACTTCTGGGGCCGA
GTAAAGAACTTCCTGATGTTCTTTGAGTTCTTCAAGAAGCAGTGGAAAATCCAGTCTGCA
TATGATGACACCATCAAGGAGCATTTCCCGGACGACTCTAGGCCAGTTTTGTCTCATCTT
CTAACAAAAGCAGAGCTGTGGTTTGTTAACACCGACTTTGCCTTTGATTTTGCTCGGCCC
CTGCTTCCCAACACTGTGTGTATTGGAGGTTTAATGTCCAAACCTGTTAAACCAGTACCA
CAAGAATTTGAGAATTTCATCACCAAATTTGGAGACTCTGGTTTTGTCCTTGTAAGCCTG
GGGTCCATGGTGAGTTTCATTCGGTCCCAGGAGGTTCTCAAAGAGATGAATGCTGCCTTT
GCTCATCTCCCTCAAGGGGTGATATGGAAGTATAATCCTTCTCATTGGCCCAAAGACATC
AAATTGGCCCCAAATGTGAAAATTGTGCACTGGCTTCCTCAGAATGACCTTCTGGGGCAC
CCTCGCATCCGCCTCTTTGTCAGCCATGGTGGGATGAATAGTATCATGGAGGCCATCCAA
CATGGTGTGCCCATGGTGGGGATTCCCCTCTTTGGAGACCAACATGAAAACCTGCTCCGA
GTTAAAGCCAAAAAGTTCGGTGTCTCTATCCAATTAAAGCAGATCAAGGCTGAGACACTG
GCTCTGAAGATGAAGCAAGTCATAGAGGACAAGAGGTACAAATCTGCCGCAGAGGCCGCC
AGCATCATCAGACGCTCGCAGCCCCTGACCCCTGCCCAGCGGCTGGTGGGCTGGATTAAC
CACATCCTTCAGACAGGGGGTGCAGCCCACCTCAAGCCCCATGCCTTCCAGCAGCCGTGG
TATGAGCAGTACCTACTGGACGTCTTCTTGTTCCTTCTGGTGGTCACCCTGGGCACCATG
TGGCTCTGTGGGAAGCTTCTGGGCCTGGTGGCCAGGTGGCTGTGTGGGGCCAGGAAGCTG
AAGAAGGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 523 |
| Molecular Weight
| 59682.0 |
| Theoretical pI
| 9.6 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>UDP-glucuronosyltransferase 3A1
MAGQQALLLFGFILPGLLFSEAAKILTVSLVGGSHFLLMHQISQILQDHGHNVTMLLQKG
NLLLPGFKEEEKSYKVFNWFLPEDCNEEFKRSFHSFMEKTFGGRCKFEHFLNIMELLGHH
CSHLLRRKDVMKSLKNENFDLVIVEMFDYCPFLVAEKLGKPFVAILPSALGTVDFGLPSP
LSYVPVFYSLLTDQMDFWGRVKNFLMFFEFFKKQWKIQSAYDDTIKEHFPDDSRPVLSHL
LTKAELWFVNTDFAFDFARPLLPNTVCIGGLMSKPVKPVPQEFENFITKFGDSGFVLVSL
GSMVSFIRSQEVLKEMNAAFAHLPQGVIWKYNPSHWPKDIKLAPNVKIVHWLPQNDLLGH
PRIRLFVSHGGMNSIMEAIQHGVPMVGIPLFGDQHENLLRVKAKKFGVSIQLKQIKAETL
ALKMKQVIEDKRYKSAAEAASIIRRSQPLTPAQRLVGWINHILQTGGAAHLKPHAFQQPW
YEQYLLDVFLFLLVVTLGTMWLCGKLLGLVARWLCGARKLKKA
|
| External Links |
|---|
| GenBank ID Protein
| AAI15989.1 |
| UniProtKB/Swiss-Prot ID
| Q1LZI1 |
| UniProtKB/Swiss-Prot Entry Name
| UD3A1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC115988 |
| GeneCard ID
| UGT3A1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
