Identification |
BMDB Protein ID
| BMDBP01075 |
Secondary Accession Numbers
| |
Name
| Thiamin pyrophosphokinase 1 |
Synonyms
|
Not Available
|
Gene Name
| TPK1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Coenzyme transport and metabolism |
Specific Function
| Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate (By similarity). |
Pathways
|
- Cofactor biosynthesis
- Thiamine diphosphate biosynthesis
- Thiamine diphosphate from thiamine: step 1/1
|
Reactions
|
Adenosine triphosphate + Thiamine → Adenosine monophosphate + Thiamine pyrophosphate |
details
|
Adenosine triphosphate + Thiamine pyrophosphate → ADP + Thiamin triphosphate |
details
|
|
GO Classification
|
Not Available
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| 4 |
Locus
| Not Available |
SNPs
| TPK1 |
Gene Sequence
|
>732 bp
ATGGAGCATGCCATTACCCCGCTGGACCCCCTGCTTCCCTCTGGGAGTTTGAAATACTGC
CTTGTGATTCTGAACCAGCCTTTGGACAAATGTTTTCGTCATCTTTGGCACAAAGCTCTT
TTAAGAGCCTGTGCTGATGGAGGTGCCAACCACTTATATGACGTCACAGAAGGAGAGAGG
GAGAGCTTTCTGCCTGAATTCATCAGTGGAGACTTTGATTCTATTAGGCCTGAAGTTAGA
GAACACTACGCTATTAAGGGCTGTGAAATTATTTCAACTCCTGATCAAGACCATACTGAT
TTTACCAAGTGCCTTGAAGTGCTCCAAAAGAAGATAGAAGAAAAAGACCTACAGGTAGAT
ATGATCGTGACCTTGGGAGGACTTGCTGGACGCTTTGACCAGATCATGGCATCTGTGAGC
ACTTTGTTCCAAGCGCCTCAAATAACTTCTTTGCCAGTTATAATAATCCAAGAGGAATCT
CTCATCTACCTGCTCCAACCGGGAAAGCACAAATTGCATGTAGATACCGGGATGGAAGGT
GATTGGTGTGGCCTCATTCCTGTTGGACAGCCTTGCAATCAGGTGACCACAACAGGCCTA
AAGTGGAACCTTACACATCAGATGCTTGGCTTTGGAACACTAGTCAGCACGTCCAACACC
TACGACGGATCTGGTGTTGTGACTGTAGAGACGGACCATCCCCTGCTCTGGACCATGGCC
ATAAAAAACTGA
|
Protein Properties |
Number of Residues
| 243 |
Molecular Weight
| 27028.0 |
Theoretical pI
| 4.94 |
Pfam Domain Function
|
Not Available |
Signals
|
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Thiamin pyrophosphokinase 1
MEHAITPLDPLLPSGSLKYCLVILNQPLDKCFRHLWHKALLRACADGGANHLYDVTEGER
ESFLPEFISGDFDSIRPEVREHYAIKGCEIISTPDQDHTDFTKCLEVLQKKIEEKDLQVD
MIVTLGGLAGRFDQIMASVSTLFQAPQITSLPVIIIQEESLIYLLQPGKHKLHVDTGMEG
DWCGLIPVGQPCNQVTTTGLKWNLTHQMLGFGTLVSTSNTYDGSGVVTVETDHPLLWTMA
IKN
|
External Links |
GenBank ID Protein
| AAX08853.1 |
UniProtKB/Swiss-Prot ID
| Q5E9T4 |
UniProtKB/Swiss-Prot Entry Name
| TPK1_BOVIN |
PDB IDs
|
|
GenBank Gene ID
| BT020836 |
GeneCard ID
| TPK1 |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| Not Available |