Showing Protein Histidine--tRNA ligase, cytoplasmic (BMDBP01135)
| Identification | |||
|---|---|---|---|
| BMDB Protein ID | BMDBP01135 | ||
| Secondary Accession Numbers | None | ||
| Name | Histidine--tRNA ligase, cytoplasmic | ||
| Synonyms | Not Available | ||
| Gene Name | HARS1 | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Translation, ribosomal structure and biogenesis | ||
| Specific Function | Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance. | ||
| Pathways |
|
||
| Reactions |
|
||
| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 7 | ||
| Locus | Not Available | ||
| SNPs | HARS1 | ||
| Gene Sequence |
>1530 bp ATGGCTGATCGTGCGGCGCTGGAGGATCTGGTGCGAGTTCAGGGAGAGCGTGTGCGGGGC CTTAAGCAGCAGAAGGCCAGCGCGGAGCAGATCGAGGAGGAGGTGGCAAAACTACTGAAA CTGAAGGCACAGCTGGGCCCTGATGAAGGAAAACCGAAGTTTGTGCTCAAAACCCCCAAG GGCACAAGAGATTATAGTCCCCGGCAGATGGCAGTTCGAGAGAAGGTGTTTGATGTAATC ATCAGCTGCTTCAAGCGCCATGGTGCAGAAGTGATTGATACACCTGTATTTGAACTAAAG GAAACACTGACTGGAAAGTATGGAGAAGACTCTAAGCTTATCTATGACTTGAAGGACCAG GGTGGGGAGCTGCTCTCTCTTCGATATGACCTCACTGTTCCTTTTGCTCGATACTTGGCA ATGAATAAACTGACCAACATTAAACGCTACCACATAGCAAAAGTATATCGGCGGGATAAC CCAGCCATGACCCGAGGCCGATATCGGGAATTCTACCAATGTGATTTTGACATTGCTGGG CAGTTTGACCCCATGCTTCCTGATGCAGAGTGCCTGAAGATCATGTGTGAGATCCTGAGT TCACTCCAGATTGGCGACTTCCTGGTCAAGGTGAATGATCGGCGCATCTTAGATGGGATG TTTGCCATCTGTGGTGTTCCAGATAGCAAGTTCCGCACCATCTGCTCCTCTGTGGACAAG CTGGACAAGGTGTCCTGGGAGGAAGTAAAGAATGAGATGGTAGGAGAGAAGGGCCTGGCA CCTGAGGTGGCTGACCGCATTGGGGACTACGTCCAGCAACACGGTGGAGTATCCCTGGTG GAACAGCTGCTCCAGGATCCTAAACTGTCCCAGAACAAGCAGGCCCTCGAGGGCCTGGGA GACCTGAAGCTGCTATTTGAGTATCTGACCTTGTTTGGCATTGCTGACAAGATCTCCTTC GACCTGAGCCTTGCTCGAGGACTGGACTACTATACCGGCGTGATCTATGAGGCAGTGCTG CTACAGCCTCCAGCCCGAGCAGGGGAAGAACCCCTGGGTGTGGGCAGCGTGGCTGCTGGA GGGCGCTATGATGGGCTGGTGGGCATGTTTGATCCCAAAGGGCGCAAGGTGCCCTGTGTA GGGCTCAGCATTGGAGTAGAGCGGATCTTTTCCATCGTGGAGCAGAGGCTGGAGGCCTTG GAGGAGAAGGTACGGACCACAGAGACACAGGTGCTTGTGGCATCTGCACAGAAGAAGCTG CTGGAAGAGAGACTGAAGCTCATCTCAGAGTTATGGGATGCTGGGATCAAGGCAGAACTG CTCTACAAAAAGAACCCCAAGTTACTGAATCAGCTGCAGTACTGTGAGGAGACAGGCATC CCACTGGTGGCCATCATTGGTGAGCAAGAGCTCAAGGATGGGGTCATCAAGCTGCGCTCA GTGGCCAGCAGGGAAGAGGTGGACGTCCGAAGAGAAGACCTTGTGGAGGAAATCAAAAGG AGAACAAGCCAGCCGCTTTGCATCTGCTGA |
||
| Protein Properties | |||
| Number of Residues | 509 | ||
| Molecular Weight | 57285.0 | ||
| Theoretical pI | 5.75 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
|
||
| Transmembrane Regions | Not Available | ||
| Protein Sequence |
>Histidyl-tRNA synthetase, cytoplasmic MADRAALEDLVRVQGERVRGLKQQKASAEQIEEEVAKLLKLKAQLGPDEGKPKFVLKTPK GTRDYSPRQMAVREKVFDVIISCFKRHGAEVIDTPVFELKETLTGKYGEDSKLIYDLKDQ GGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAG QFDPMLPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVPDSKFRTICSSVDK LDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLG DLKLLFEYLTLFGIADKISFDLSLARGLDYYTGVIYEAVLLQPPARAGEEPLGVGSVAAG GRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKVRTTETQVLVASAQKKL LEERLKLISELWDAGIKAELLYKKNPKLLNQLQYCEETGIPLVAIIGEQELKDGVIKLRS VASREEVDVRREDLVEEIKRRTSQPLCIC |
||
| External Links | |||
| GenBank ID Protein | AAI12732.1 | ||
| UniProtKB/Swiss-Prot ID | Q2KI84 | ||
| UniProtKB/Swiss-Prot Entry Name | HARS1_BOVIN | ||
| PDB IDs | Not Available | ||
| GenBank Gene ID | BC112731 | ||
| GeneCard ID | HARS1 | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||