| Identification |
|---|
| BMDB Protein ID
| BMDBP01136 |
| Secondary Accession Numbers
| None |
| Name
| Histidine--tRNA ligase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| HARS2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Translation, ribosomal structure and biogenesis |
| Specific Function
| Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). |
| Pathways
|
|
| Reactions
|
| Adenosine triphosphate + L-Histidine + tRNA(His) → Adenosine monophosphate + Pyrophosphate + L-Histidyl-tRNA(His) |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| HARS2 |
| Gene Sequence
|
>1521 bp
ATGCCCCAGCTTGGACTCCTACCTGGGAGAGCCTGGACTGTGTTGCTTGGCCTACTCCGG
CCGCCGCCCGGTGCTCTGTGCATCAGGGCAGTCCGTTCTCACAGTCAGGTTGCAGAGGCA
CTGTTTGCATCCCAACTGAAACCTCATCAAGAGAAGTCAAATTTTACTATCAAGACCCCA
AAGGGTACCAGAGATCTTAGTCCCCAGCAGATGGTGGTGAGGGAGAAAATTCTTGATGTG
GTTGTTAGCTGCTTTAAACGTCATGGAGCAAAGGGGTTGGATACCCCGGCATTTGAACTA
AAGGAAATACTTACTGAGAAGTATGGAGAGGACTCTGGACTCATCTATGATCTGAAGGAT
CAGGGCGGAGAGCTGTTGTCATTGCGCTATGACCTTACTGTCCCTTTTGCTCGTTATCTG
GCCATGAATAAAGTGAAGAAGATGAAACGCTATCATGTTGGAAAAGTGTGGCGGCGGGAG
AGCCCAACCATAGTCCAAGGCCGCTACCGGGAGTTCTACCAGTGTGATTTTGACATTGCT
GGTCAATTTGACCCTATGATCCCTGATGCAGAATGTTTGAAGATCATGTGTGAAATCCTT
AGTGGATTGCACCTGGGGGATTTTCTCATTAAGGTCAGTGACCGACGGATTTTGGATGGG
ATATTTGCTGTCTGTGGTGTTCCTGAAAGCAAGTTCCATGCCATTTGCTCCTCGGTAGAC
AAACTAGATAAGATATCTTGGAAAGATGTGAGACATGAGATGGTGGTAAAGAAAGGCCTG
GCTCCTGAAGTGGCTGATCGAATTGGGGATTATGTCCAATGTCATGGTGGGATATCCTTG
GTGGAGCAAATGTTCCAGGATCCCAGACTATCCCAGAACAAGCAGGCCCTAGAGGGGTTG
GGAGACCTGAAGCTGCTGTTTGAATACCTGACTTTATTTGGAGTTGCTGAGAAGGTCTCC
TTTGACCTGAGCTTGGCTCGAGGCCTGGACTACTATACAGGAGTGATCTATGAAGCAGTG
CTGCTACAGACCCCAGTGCATGCTGAGGAGGAGCCCCTGAATATGGGCAGTGTGGCTGCT
GGTGGTCGCTATGATGGGCTGGTGGGCATGTTTGACCCCAGAGGCCACAAGGTGCCATGT
GTGGGGCTCAGCATTGGGGTAGAGCGAATCTTCTCCATTGTGGAGCAGAGGATAAAGACT
TTTGGTGAGAAGATACGGACCACAGAGACCCAAGTGTTTGTGGCCACACCACAGAAGAAC
TTTCTTCAAGAACGGTTGAAGCTAATTGCAGAGCTTTGGGATGCTGGGATCAAGGCAGAG
CTGATGTATAAGAACAACCCTAAACTACTACCCCAACTGCACTACTGTGAGAACATGGGA
ATTCCACTGGTGGTCATTATTGGTGAGCAAGAACTGAAGGAAGGGGTCATCAAGCTCCGT
TCAGTGGCCAGCAGGGAGGAGGTGGCCATTAAACGGGAAAATCTAGTGGCTGAAATTCAG
AAACGACTGTCTGAATCTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 506 |
| Molecular Weight
| 56914.0 |
| Theoretical pI
| 8.09 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Probable histidyl-tRNA synthetase, mitochondrial
MPQLGLLPGRAWTVLLGLLRPPPGALCIRAVRSHSQVAEALFASQLKPHQEKSNFTIKTP
KGTRDLSPQQMVVREKILDVVVSCFKRHGAKGLDTPAFELKEILTEKYGEDSGLIYDLKD
QGGELLSLRYDLTVPFARYLAMNKVKKMKRYHVGKVWRRESPTIVQGRYREFYQCDFDIA
GQFDPMIPDAECLKIMCEILSGLHLGDFLIKVSDRRILDGIFAVCGVPESKFHAICSSVD
KLDKISWKDVRHEMVVKKGLAPEVADRIGDYVQCHGGISLVEQMFQDPRLSQNKQALEGL
GDLKLLFEYLTLFGVAEKVSFDLSLARGLDYYTGVIYEAVLLQTPVHAEEEPLNMGSVAA
GGRYDGLVGMFDPRGHKVPCVGLSIGVERIFSIVEQRIKTFGEKIRTTETQVFVATPQKN
FLQERLKLIAELWDAGIKAELMYKNNPKLLPQLHYCENMGIPLVVIIGEQELKEGVIKLR
SVASREEVAIKRENLVAEIQKRLSES
|
| External Links |
|---|
| GenBank ID Protein
| AAI40700.1 |
| UniProtKB/Swiss-Prot ID
| A5D7V9 |
| UniProtKB/Swiss-Prot Entry Name
| SYHM_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC140699 |
| GeneCard ID
| HARS2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
