Showing Protein cAMP-dependent protein kinase catalytic subunit beta (BMDBP01158)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 metabolites
Identification
BMDB Protein ID BMDBP01158
Secondary Accession Numbers
  • BMDBP03166
Name cAMP-dependent protein kinase catalytic subunit beta
Synonyms Not Available
Gene Name PRKACB
Protein Type Enzyme
Biological Properties
General Function Involved in ATP binding
Specific Function Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, and differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA.
Pathways Not Available
Reactions
Cyclic AMP → Cyclic AMP + cAMP-dependent protein kinase catalytic subunit beta details
Ethylene-responsive transcription factor ESR1 → Ethylene-responsive transcription factor ESR1 + Hydrogen phosphate details
Cyclic AMP-responsive element-binding protein 1 → Cyclic AMP-responsive element-binding protein 1 + Hydrogen phosphate details
Myosin light chain kinase, smooth muscle → Myosin light chain kinase, smooth muscle + Hydrogen phosphate details
Rho guanine nucleotide exchange factor 7 → Rho guanine nucleotide exchange factor 7 with phosphate details
RAC-alpha serine/threonine-protein kinase → RAC-alpha serine/threonine-protein kinase with phosphorylation details
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 3
Locus Not Available
SNPs PRKACB
Gene Sequence 
>1056 bp
CCTTCCTCCCATCGCCCCAGTCATGGGGAACGCGGCGACCGCCAAGAAAGGCAGCGAGGT
GGAGAGCGTGAAAGAGTTTCTAGCCAAAGCCAAAGAAGACTTTTTAAAAAAATGGGAAAA
TCCTGCTCCGAATAATGCTGGGCTGGAGGATTTTGAAAGGAAAAAAACCCTTGGAACAGG
TTCATTTGGAAGAGTCATGTTGGTGAAACACAAAGCCACTGAACAGTATTATGCCATGAA
GATCTTAGATAAGCAGAAGGTTGTTAAACTGAAGCAAATAGAGCATACTTTGAATGAGAA
AAGAATATTACAGGCAGTGAATTTTCCTTTTCTTGTTCGACTGGAATATGCTTTTAAGGA
TAATTCTAATTTATACATGGTTATGGAATATGTTCCTGGTGGTGAAATGTTTTCACATCT
AAGAAGAATTGGAAGGTTCAGTGAACCCCATGCACGGTTCTATGCAGCTCAGATAGTGCT
AACATTCGAGTACCTCCATTCACTAGACCTCATCTACAGAGATCTAAAACCTGAAAATCT
CTTAATTGACCACCAAGGTTATATCCAGGTCACAGACTTTGGGTTTGCCAAAAGAGTTAA
AGGCAGAACTTGGACATTATGTGGCACTCCAGAATATTTGGCTCCAGAAATCATTCTCAG
CAAGGGCTACAATAAGGCAGTGGATTGGTGGGCGTTAGGAGTGTTAATCTATGAAATGGC
GGCTGGCTACCCCCCATTCTTTGCAGACCAACCAATTCAGATTTATGAAAAAATTGTTTC
TGGAAAGGTTCGATTCCCTTCTCACTTCAGTTCAGATCTCAAGGACCTTCTAAGGAACCT
GCTGCAGGTAGACTTAACAAAGCGGTTTGGAAATCTAAAGAATGGTGTGAGTGACATAAA
AACTCACAAGTGGTTTGCCACAACAGACTGGATTGCTATTTACCAGAGAAAGGTTGAAGC
TCCATTCATACCAAAGTTCAGAGGCTCTGGAGATACCAGCAACTTTGATGACTATGAAGA
AGAAGATATCCGTGTCTCTATAACAGAAAAATGTGG
Protein Properties
Number of Residues 351
Molecular Weight 40594.0
Theoretical pI 9.06
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions Not Available
Protein Sequence 
>cAMP-dependent protein kinase catalytic subunit beta
MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPAPNNAGLEDFERKKTLGTGSFGRVML
VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFAT
TDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCGKEFCEF
GenBank ID Protein AAA30707.1
UniProtKB/Swiss-Prot ID P05131
UniProtKB/Swiss-Prot Entry Name KAPCB_BOVIN
PDB IDs
GenBank Gene ID J02647
GeneCard ID PRKACB
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available