| Identification |
|---|
| BMDB Protein ID
| BMDBP01158 |
| Secondary Accession Numbers
| |
| Name
| cAMP-dependent protein kinase catalytic subunit beta |
| Synonyms
|
Not Available
|
| Gene Name
| PRKACB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, and differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA. |
| Pathways
|
Not Available
|
| Reactions
|
| Cyclic AMP → Cyclic AMP + cAMP-dependent protein kinase catalytic subunit beta |
details
|
| Ethylene-responsive transcription factor ESR1 → Ethylene-responsive transcription factor ESR1 + Hydrogen phosphate |
details
|
| Cyclic AMP-responsive element-binding protein 1 → Cyclic AMP-responsive element-binding protein 1 + Hydrogen phosphate |
details
|
| Myosin light chain kinase, smooth muscle → Myosin light chain kinase, smooth muscle + Hydrogen phosphate |
details
|
| Rho guanine nucleotide exchange factor 7 → Rho guanine nucleotide exchange factor 7 with phosphate |
details
|
| RAC-alpha serine/threonine-protein kinase → RAC-alpha serine/threonine-protein kinase with phosphorylation |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| PRKACB |
| Gene Sequence
|
>1056 bp
CCTTCCTCCCATCGCCCCAGTCATGGGGAACGCGGCGACCGCCAAGAAAGGCAGCGAGGT
GGAGAGCGTGAAAGAGTTTCTAGCCAAAGCCAAAGAAGACTTTTTAAAAAAATGGGAAAA
TCCTGCTCCGAATAATGCTGGGCTGGAGGATTTTGAAAGGAAAAAAACCCTTGGAACAGG
TTCATTTGGAAGAGTCATGTTGGTGAAACACAAAGCCACTGAACAGTATTATGCCATGAA
GATCTTAGATAAGCAGAAGGTTGTTAAACTGAAGCAAATAGAGCATACTTTGAATGAGAA
AAGAATATTACAGGCAGTGAATTTTCCTTTTCTTGTTCGACTGGAATATGCTTTTAAGGA
TAATTCTAATTTATACATGGTTATGGAATATGTTCCTGGTGGTGAAATGTTTTCACATCT
AAGAAGAATTGGAAGGTTCAGTGAACCCCATGCACGGTTCTATGCAGCTCAGATAGTGCT
AACATTCGAGTACCTCCATTCACTAGACCTCATCTACAGAGATCTAAAACCTGAAAATCT
CTTAATTGACCACCAAGGTTATATCCAGGTCACAGACTTTGGGTTTGCCAAAAGAGTTAA
AGGCAGAACTTGGACATTATGTGGCACTCCAGAATATTTGGCTCCAGAAATCATTCTCAG
CAAGGGCTACAATAAGGCAGTGGATTGGTGGGCGTTAGGAGTGTTAATCTATGAAATGGC
GGCTGGCTACCCCCCATTCTTTGCAGACCAACCAATTCAGATTTATGAAAAAATTGTTTC
TGGAAAGGTTCGATTCCCTTCTCACTTCAGTTCAGATCTCAAGGACCTTCTAAGGAACCT
GCTGCAGGTAGACTTAACAAAGCGGTTTGGAAATCTAAAGAATGGTGTGAGTGACATAAA
AACTCACAAGTGGTTTGCCACAACAGACTGGATTGCTATTTACCAGAGAAAGGTTGAAGC
TCCATTCATACCAAAGTTCAGAGGCTCTGGAGATACCAGCAACTTTGATGACTATGAAGA
AGAAGATATCCGTGTCTCTATAACAGAAAAATGTGG
|
| Protein Properties |
|---|
| Number of Residues
| 351 |
| Molecular Weight
| 40594.0 |
| Theoretical pI
| 9.06 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>cAMP-dependent protein kinase catalytic subunit beta
MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPAPNNAGLEDFERKKTLGTGSFGRVML
VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFAT
TDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCGKEFCEF
|
| External Links |
|---|
| GenBank ID Protein
| AAA30707.1 |
| UniProtKB/Swiss-Prot ID
| P05131 |
| UniProtKB/Swiss-Prot Entry Name
| KAPCB_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| J02647 |
| GeneCard ID
| PRKACB |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
