Identification |
BMDB Protein ID
| BMDBP01344 |
Secondary Accession Numbers
| None |
Name
| Calcium-activated potassium channel subunit alpha-1 |
Synonyms
|
Not Available
|
Gene Name
| KCNMA1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Inorganic ion transport and metabolism |
Specific Function
| Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX) (By similarity). |
Pathways
|
Not Available
|
Reactions
| Not Available |
GO Classification
|
Not Available
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| 28 |
Locus
| Not Available |
SNPs
| KCNMA1 |
Gene Sequence
|
>3501 bp
ATGGCAAATGGTGGCGGCGGCGGCGGCGGCGGCGGCGGAGGCAGCAGTCTTAGAATGAGC
AGCAATATCCACGCGAACCATCTCAGCCTAGACGCGTCCTCCTCCTCCTCTTCTTCCTCC
TCCTCCTCTTCCTCGTCGTCCTCGGTCCACGAGCCCAAGATGGATGCGCTCATCATCCCG
GTGACCATGGAGGTGCCGTGCGACAGCCGGGGCCAACGGATGTGGTGGGCTTTCCTGGCC
TCCTCCATGGTGACTTTCTTCGGCGGCCTCTTCATCATCTTGCTCTGGAGGACGCTCAAG
TACCTGTGGACCGTTTGCTGCCACTGCGGGGGCAAAACGAAGGAGGCCCAGAAGATTAAC
AATGGCTCAAGCCAGGCAGATGGCACTCTCAAGCCAGTGGATGAAAAAGAGGAGACGGTG
GCAGCCGAGGTCGGCTGGATGACCTCCGTGAAAGACTGGGCGGGGGTGATGATATCTGCC
CAGACGCTGACTGGCAGAGTCCTGGTTGTCTTAGTCTTTGCTCTCAGCATTGGTGCACTT
GTAATATACTTCATAGATTCGTCAAACCCAATAGAATCCTGCCAGAATTTCTACAAAGAT
TTCACATTACAGATCGACATGGCGTTCAACGTATTCTTCCTTCTCTACTTTGGCTTGCGG
TTTATTGCAGCCAACGATAAGCTATGGTTCTGGCTTGAAGTGAACTCTGTGGTAGATTTC
TTCACGGTCCCCCCTGTGTTTGTGTCCGTGTACTTAAACAGAAGTTGGCTTGGTTTGAGA
TTTTTAAGAGCTCTCAGACTGATCCAGTTTTCAGAAATTTTACAGTTTCTGAATATCCTG
AAAACAAGTAATTCCATCAAGCTGGTGAATCTGCTCTCCATTTTTATCAGCACGTGGCTC
ACAGCAGCCGGGTTCATCCATTTGGTGGAGAATTCAGGGGACCCATGGGAAAATTTCCAA
AACAACCAGGCTCTTACCTACTGGGAATGTGTCTATCTGCTCATGGTGACCATGTCCACT
GTTGGTTACGGGGATGTTTATGCAAAAACCACGCTCGGGCGTCTCTTCATGGTCTTCTTC
ATCCTCGGGGGACTGGCCATGTTTGCCAGCTACGTCCCTGAAATCATAGAGTTAATAGGA
AACCGCAAGAAATACGGGGGCTCCTATAGTGCGGTTAGTGGAAGAAAGCACATAGTGGTC
TGTGGACACATCACACTGGAGAGCGTTTCCAACTTCCTGAAGGACTTTCTGCACAAGGAC
CGGGACGATGTCAATGTGGAGATCGTCTTTCTTCACAACATCTCCCCTAACCTGGAGCTG
GAAGCCTTGTTCAAACGACATTTTACTCAGGTGGAGTTTTATCAGGGTTCAGTCCTCAAT
CCACATGATCTTGCAAGAGTCAAGATAGAGTCAGCAGATGCGTGCCTGATCCTTGCCAAT
AAGTACTGCGCAGACCCCGATGCTGAAGATGCCTCCAACATCATGAGAGTCATCTCCATA
AAGAACTACCACCCGAAGATAAGAATCATCACTCAGATGCTGCAGTATCACAATAAGGCC
CATCTGCTAAACATCCCGAGCTGGAATTGGAAAGAGGGGGATGATGCAATCTGCCTCGCA
GAACTGAAGCTGGGGTTCATCGCCCAGAGCTGCCTGGCTCAAGGGCTCTCCACCATGCTC
GCCAACCTCTTCTCCATGAGGTCATTCATAAAGATTGAGGAAGACACGTGGCAGAAATAC
TACTTGGAAGGAGTCTCAAATGAAATGTACACAGAATATCTCTCCAGTGCCTTCGTGGGT
CTGTCCTTCCCGACTGTTTGTGAGCTGTGTTTTGTGAAGCTCAAGCTTCTCATGATAGCC
ATTGAGTACAAGTCCGCCAATCGAGAGAGCCGTATATTAATTAATCCTGGAAACCATCTT
AAGATCCAAGAAGGTACTTTAGGATTTTTCATCGCAAGTGATGCCAAAGAAGTTAAAAGG
GCATTTTTTTACTGCAAGGCCTGTCATGATGACATCACGGATCCCAAAAGGATAAAAAAA
TGCGGCTGCAAACGGCTTGAAGATGAACAGCCGTCGACACTGTCACCCAAAAAAAAGCAG
CGCAACGGAGGCATGCGGAACTCACCCAGCTCGTCGCCCAAGCTGATGAGGCATGACCCC
TTGTTAATTCCTGGCAATGATCAGATTGACAACATGGACTCCAATGTGAAGAAATATGAC
TCTACTGGGATGTTTCACTGGTGTGCGCCCAAGGAGATAGAGAAAGTCATCCTGACCCGA
AGTGAAGCTGCCATGACCGTCCTGAGCGGCCACGTGGTGGTCTGCATCTTTGGCGACGTC
AGCTCTGCCCTGATTGGCCTTCGGAACCTGGTGATGCCGCTCCGTGCCAGCAACTTTCAC
TACCACGAGCTCAAGCACATCGTGTTTGTGGGCTCCATCGAGTACCTCAAGCGGGAATGG
GAGACACTGCATAACTTCCCCAAGGTTTCCATCTTGCCTGGTACGCCATTAAGTCGGGCT
GATTTAAGGGCCGTCAACATCAACCTCTGTGACATGTGCGTTATCCTGTCAGCCAATCAG
AATAATATTGATGATACTTCGCTGCAGGACAAGGAATGCATCTTGGCGTCACTCAACATC
AAATCTATGCAGTTTGATGACAGCATCGGGGTCTTGCAGGCTAATTCCCAAGGGTTCACA
CCTCCAGGAATGGACCGATCCTCACCAGATAACAGCCCGGTACATGGGATGTTACGCCAG
CCCTCCATCACTACTGGGGTCAACATCCCCATCATCACTGAACTAGTGAACGATACTAAT
GTTCAGTTTTTGGACCAAGACGATGACGATGACCCCGACACAGAACTGTACCTCACGCAG
CCGTTTGCATGTGGGACAGCGTTCGCCGTCAGTGTCCTGGATTCACTCATGAGCGCAACA
TACTTCAATGACAACATCCTTACCCTGATACGGACCCTGGTGACTGGAGGAGCCACACCA
GAGCTGGAGGCTTTGATCGCTGAGGAGAATGCACTCCGCGGGGGCTACAGCACCCCCCAG
ACGCTGGCCAACAGGGACCGCTGCCGTGTGGCCCAGTTAGCGCTGCTGGACGGGCCCTTT
GCGGACCTGGGGGATGGTGGTTGTTATGGTGATCTGTTCTGCAAAGCTCTGAAAACATAC
AATATGCTTTGTTTTGGAATTTATCGGCTGAGAGATGCTCACCTCAGCACCCCCAGCCAG
TGCACGAAGAGGTATGTCATCACCAACCCCCCGTACGAGTTTGAGCTCGTGCCGACGGAC
CTGATCTTCTGCTTAATGCAGTTTGACCACAACGCCGGCCAGTCCCGGGCCAGCCTCTCC
CATTCCTCCCACTCGTCCCAGTCCTCTAGCAAGAAGAGCTCCTCCGTCCACTCCATCCCA
TCCACGGCAAACCGACAGAACCGGCCCAAGTCCCGGGAGTCCCGAGACAAACAGAAGTAC
GTGCAGGAAGAGCGGCTCTGA
|
Protein Properties |
Number of Residues
| 1166 |
Molecular Weight
| 130063.0 |
Theoretical pI
| 6.76 |
Pfam Domain Function
|
Not Available |
Signals
|
|
Transmembrane Regions
|
- 75-95
- 167-187
- 203-223
- 228-248
- 253-273
- 289-309
- 356-376
|
Protein Sequence
|
>Calcium-activated potassium channel subunit alpha-1
MANGGGGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSVHEPKMDALIIP
VTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKIN
NGSSQADGTLKPVDEKEETVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGAL
VIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDF
FTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWL
TAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFF
ILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKD
RDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILAN
KYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLA
ELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVG
LSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKR
AFFYCKACHDDITDPKRIKKCGCKRLEDEQPSTLSPKKKQRNGGMRNSPSSSPKLMRHDP
LLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDV
SSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRA
DLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFT
PPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQ
PFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQ
TLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQ
CTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIP
STANRQNRPKSRESRDKQKYVQEERL
|
External Links |
GenBank ID Protein
| AAK54352.1 |
UniProtKB/Swiss-Prot ID
| Q28204 |
UniProtKB/Swiss-Prot Entry Name
| KCMA1_BOVIN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AY033472 |
GeneCard ID
| KCNMA1 |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| Not Available |