Showing Protein Cleavage and polyadenylation specificity factor subunit 5 (BMDBP02090)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP02090 |
| Secondary Accession Numbers | None |
| Name | Cleavage and polyadenylation specificity factor subunit 5 |
| Synonyms | Not Available |
| Gene Name | NUDT21 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in hydrolase activity |
| Specific Function | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7. Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function. Binds to chromatin. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 18 |
| Locus | Not Available |
| SNPs | NUDT21 |
| Gene Sequence |
>684 bp ATGTCCGTGGTGCCGCCCAATCGCTCGCAGACCGGCTGGCCCCGGGGAGTCACCCAGTTC GGCAACAAGTATATCCAGCAGACCAAGCCCCTCACCCTGGAGCGCACCATCAACCTGTAC CCTCTTACCAATTACACTTTTGGTACAAAAGAACCCCTCTATGAGAAGGACAGCTCTGTT GCAGCCAGATTTCAGCGCATGAGGGAGGAATTTGATAAAATTGGCATGAGGAGGACTGTA GAAGGGGTTTTGATTGTCCATGAGCACCGGCTACCCCATGTGTTACTGCTACAGCTGGGA ACAACGTTCTTCAAATTACCTGGTGGTGAGCTTAATCCAGGAGAAGATGAAGTTGAAGGA CTAAAACGCTTAATGACAGAGATATTGGGTCGTCAAGATGGAGTCCTGCAAGACTGGGTT ATCGATGACTGCATTGGCAACTGGTGGAGACCAAATTTTGAGCCTCCTCAGTATCCATAT ATTCCTGCACATATTACAAAACCTAAGGAACATAAGAAGTTGTTTCTGGTTCAGCTTCAA GAGAAAGCCTTGTTTGCAGTCCCTAAAAATTACAAGCTGGTAGCTGCACCGCTATTTGAA CTGTATGACAATGCACCTGGATATGGACCCATCATTTCTAGTCTCCCCCAGCTTTTGAGC AGGTTCAATTTTATATACAACTGA |
| Protein Properties | |
| Number of Residues | 227 |
| Molecular Weight | 26227.0 |
| Theoretical pI | 9.18 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Cleavage and polyadenylation specificity factor subunit 5 MSVVPPNRSQTGWPRGVTQFGNKYIQQTKPLTLERTINLYPLTNYTFGTKEPLYEKDSSV AARFQRMREEFDKIGMRRTVEGVLIVHEHRLPHVLLLQLGTTFFKLPGGELNPGEDEVEG LKRLMTEILGRQDGVLQDWVIDDCIGNWWRPNFEPPQYPYIPAHITKPKEHKKLFLVQLQ EKALFAVPKNYKLVAAPLFELYDNAPGYGPIISSLPQLLSRFNFIYN |
| External Links | |
| GenBank ID Protein | AAI02698.1 |
| UniProtKB/Swiss-Prot ID | Q3ZCA2 |
| UniProtKB/Swiss-Prot Entry Name | CPSF5_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC102697 |
| GeneCard ID | NUDT21 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |