Showing Protein 3-hydroxy-3-methylglutaryl-coenzyme A reductase (BMDBP02249)
| Identification | |||
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| BMDB Protein ID | BMDBP02249 | ||
| Secondary Accession Numbers |
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| Name | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | ||
| Synonyms | Not Available | ||
| Gene Name | HMGCR | ||
| Protein Type | Enzyme | ||
| Biological Properties | |||
| General Function | Lipid transport and metabolism | ||
| Specific Function | Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins. | ||
| Pathways |
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| Reactions |
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| GO Classification | Not Available | ||
| Cellular Location | Not Available | ||
| Gene Properties | |||
| Chromosome Location | 10 | ||
| Locus | Not Available | ||
| SNPs | HMGCR | ||
| Gene Sequence |
>2667 bp ATGCTGTCAAGACTTTTCCGAATGCATGGCCTCTTCGTGGCCTCCCATCCCTGGGAAGTC ATAGTGGGGACAGTGACGCTGACCATCTGCATGATGTCCATGAACATGTTTACTGGCAAC AATAAGATCTGCGGTTGGAATTATGAATGTCCGAAGTTGGAAGAGGATGTTTTGAGCAGC GACATCATAATTCTGACAATAACACGATGCATAGCAATATTGTATATTTACTTCCAGTTC CAGAATTTACGCCAACTTGGATCAAAATATATTTTGGGTATTGCTGGACTCTTCACAATT TTCTCCAGTTTCGTATTCAGTACAGTTGTCATTCATTTCTTAGATAAAGAATTGACAGGT TTGAATGAAGCTTTGCCCTTTTTCCTGCTGCTGGTCGACCTTTCTAGAGCAAGTGCGCTA GCCAAGTTCGCCCTCAGTTCTAACTCACAGGATGAAGTGAGGGAGAACATTGCTCGTGGG ATGGCGATTTTAGGTCCCACCTTCACCCTGGATGCTCTTGTAGAATGTCTTGTGATTGGA GTTGGTACCATGTCAGGGGTGCGTCAGCTCGAAATCATGTGCTGCTTTGGCTGCATGTCG GTTCTCGCCAACTACTTTGTGTTCATGACTTTCTTCCCAGCTTGTGTGTCCTTGGTTCTG GAGCTTTCTCGGGAAAGCCGCGAGGGCCGTCCAATCTGGCAGCTCAGCCATTTTGCCCGA GTCTTAGAAGAAGAAGAAAATAAGCCAAATCCTGTTACTCAGAGGGTTAAGATGATTATG TCTCTAGGCTTGGTTCTTGTTCACGCTCACAGTCGCTGGATAGCTGATCCTTCTCCTCAA AACAGCACAGCAGACAATTCTAAGGTCTCTTTAGGACTGGATGAAAATGTGTCCAAGAGA ATTGAACCGAGTGTTTCCCTCTGGCAATTTTATCTCTCTAAAATGATCAGCATGGATATT GAACAAGTTATTACCCTAAGTTTAGCTCTCCTTCTGGCTGTCAAGTACATCTTCTTTGAA CAAGCAGAGACAGAATCTACACTCTCGTTAAAAAATCCTATCACATCTCCTGTAGTGACC CAAAAGAAAATCACAGACGATTGTTGTAGACGTGACCCTGTACTGGTCAGAAATGACCAG AAATTCCATGCAATGGAGGAGGAGACCAGGAAAAACAGAGAAAGAAAAGTTGAGGTTATA AAACCCTTACTGGCAGAAAATGACACCTCACACAGAGCCACATTCGTGGTGGGGAACTCC TCCTTACTCGGTACTTCGCTGGAACTAGAGACACAGGAGCCTGAAATGGAACTCCCTGTG GAGCCTCGGCCTAATGAAGAGTGTCTGCAGATTCTTGAGAATGCAGAGAAAGGTGCAAAA TTCCTTAGTGATGCTGAGATCATCCAGTTGGTCAATGCAAAGCATATCCCAGCTTACAAA TTGGAAACTCTGATGGAAACCCATGAGCGAGGTGTATCTATTCGCCGACAGCTACTTTCC AAAAAACTTCCAGAGCCTTCTTCTCTCCAGTATCTACCTTACAGGGACTATAATTACTCC TTGGTGATGGGAGCTTGCTGTGAGAACGTTATTGGATATATGCCCATCCCTGTTGGAGTG GCAGGACCTCTGTGCTTGGATGGAAAAGAATTTCAGGTTCCAATGGCAACAACAGAAGGC TGTCTTGTGGCCAGCACTAATAGAGGCTGCAGAGCAATAGGCCTTGGTGGAGGTGCCAGC AGCCGAGTCCTTGCAGACGGGATGACTCGTGGCCCAGTGGTGCGTTTTCCCCGTGCTTGT GACTCTGCAGAAGTGAAGGCCTGGCTTGAGACGCCTGAAGGGTTCACAGTGATAAAGGAA GCCTTCGACAGCACCAGCAGGGTTGCACGTCTACAGAAACTGCATATGAGTGTGGCCGGA CGCAACCTTTACATCCGTTTTCAGTCCAGGTCAGGTGATGCCATGGGGATGAACATGATT TCAAAGGGTACAGAGAAAGCACTGTCCAAACTTCAGGAGTATTTCCCCGAAATGCAGATT TTGGCCGTCAGTGGGAACTATTGTACAGACAAGAAACCTGCGGCCATCAACTGGATAGAG GGACGAGGAAAGTCTGTGGTCTGTGAAGCTGTCATTCCAGCCAAGGTTGTCAGAGAAGTA TTAAAGACTACAACAGAGGCTATGATTGAGGTCAACATTAATAAAAACCTGGTGGGCTCT GCCATGGCTGGGAGCATCGGCGGCTACAACGCCCACGCAGCGAACATTGTAACTGCCATC TACATTGCCTGTGGACAGGATGCAGCACAGAATGTTGGTAGTTCGAACTGTATTACTTTA ATGGAAGCAAGCGGTCCCACGAACGAAGACCTGTACATCAGCTGCACCATGCCATCTATA GAAATAGGAACCGTGGGCGGGGGCACCAACTTGCTGCCTCAGCAGGCCTGCCTGCAGATG CTAGGCGTCCAAGGAGCATGCAGAGACAACCCCGGGGAAAATGCGCGGCAGCTGGCCCGA ATCGTGTGCGGCACGGTGATGGCTGGGGAGCTGTCTCTGATGGCAGCACTGGCAGCAGGC CATCTGGTCAGAAGTCACATGATTCACAACAGGTCAAAGATAAATTTGCAAGACCTCCAA GGAACTTGCACTAAGAAGGCAGCTTGA |
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| Protein Properties | |||
| Number of Residues | 888 | ||
| Molecular Weight | 97727.0 | ||
| Theoretical pI | 6.66 | ||
| Pfam Domain Function | Not Available | ||
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>HMGCR protein MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKLEEDVLSS DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG LNEALPFFLLLVDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADNSKVSLGLDENVSKR IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQAETESTLSLKNPITSPVVT QKKITDDCCRRDPVLVRNDQKFHAMEEETRKNRERKVEVIKPLLAENDTSHRATFVVGNS SLLGTSLELETQEPEMELPVEPRPNEECLQILENAEKGAKFLSDAEIIQLVNAKHIPAYK LETLMETHERGVSIRRQLLSKKLPEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV AGPLCLDGKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRFPRAC DSAEVKAWLETPEGFTVIKEAFDSTSRVARLQKLHMSVAGRNLYIRFQSRSGDAMGMNMI SKGTEKALSKLQEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACRDNPGENARQLAR IVCGTVMAGELSLMAALAAGHLVRSHMIHNRSKINLQDLQGTCTKKAA |
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| External Links | |||
| GenBank ID Protein | AAI53263.1 | ||
| UniProtKB/Swiss-Prot ID | A7Z064 | ||
| UniProtKB/Swiss-Prot Entry Name | HMDH_BOVIN | ||
| PDB IDs | |||
| GenBank Gene ID | DAAA02027738 | ||
| GeneCard ID | HMGCR | ||
| GenAtlas ID | Not Available | ||
| HGNC ID | Not Available | ||
| References | |||
| General References | Not Available | ||