Showing Protein Contactin-1 (BMDBP02586)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP02586 |
| Secondary Accession Numbers | None |
| Name | Contactin-1 |
| Synonyms | Not Available |
| Gene Name | CNTN1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in protein binding |
| Specific Function | Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 5 |
| Locus | Not Available |
| SNPs | CNTN1 |
| Gene Sequence |
>3057 bp ATGAAAATGTGGTTACTGTTCAGTCTCCTTGTAATAATATCTTTTAAAACTTGTCTATCA GAGTTTACATGGCACAGAAGGTATGGTCATGGAGTTTCTGAGGAAGACAAAGGATTTGGA CCAATTTTTGAAGAACAACCAATCAATACCATTTATCCAGAGGAGTCACCGGAAGGAAAA GTTTCACTAAACTGTAGGGCACGAGCCAGCCCTTTCCCAGTTTACAAATGGAGAATGAAT AATGGGGATATTGATCTGACAAGTGATCGGTACAGTATGGTAGGAGGAAACCTTGTTATC AACAATCCGGACAAACAGAAAGATGCTGGAATATATTACTGTTTAGCATCAAATAACTAT GGGATGGTCAGAAGCACTGAAGCAACCCTGAGTTTTGGATATCTTGATCCTTTCCCACCT GAGGAACGTCCTGAGGTCAGAGTGAAAGAAGGGAAGGGAATGGTGCTACTCTGTGACCCT CCATACCATTTCCCAGATGATCTTAGCTACCGCTGGCTTCTAAATGAATTTCCTGTATTT ATCACAATGGATAAACGAAGATTTGTGTCTCAGACAAATGGCAATCTCTACATTGCTAAT GTTGAGGCATCTGACAAAGGCAACTATTCTTGCTTTGTATCCAGTCCCTCTATTACAAAG AGTGTGTTCAGCAAATTTATCCCACTCATTCCACTACCTGAACGAACAACAAAACCATAT CCTGCTGATATTGTAGTTCAGTTCAAGGATGTATATGCATTGATGGGCCAAAACGTGACT TTAGAGTGTTTTGCACTTGGCAATCCTGTTCCTGATATCCGATGGCGAAAAGTCCTAGAA CCAATGCCAAGCACAGCTGAGATCAGCACCTCTGGAGCTGTCCTCAAGATCTTCAATATT CAGCTAGAAGATGAAGGCATATATGAATGCGAGGCTGAGAACAATAGAGGAAAGGATAAA CACCAGGCAAGAATTTATGTTCAAGCATTTCCTGAGTGGGTGGAACACATCAATGACACA GAAGTGGATATAGGCAGTGATCTCTACTGGCCTTGTGTGGCCACGGGGAAGCCCATTCCT ACCATCCGATGGCTGAAGAATGGATATTCGTACCATAGAGGGGAACTGAGGCTGTATGAC GTGACCTTTGAAAACGCTGGCATGTACCAGTGCATAGCTGAAAACACACATGGAGCAATT TACGCAAATGCCGAGTTGAAGATCCTGGCTTTGGCTCCAACTTTTGAAATGAATCCTATG AAGAAAAAGATCCTGGCTGCTAAAGGAGGACGGGTTATAATTGAATGCAAACCCAAAGCT GCACCCAAACCAACATTTTTATGGAGTAAAGGCACAGAGCGGCTTGTCAATAGCAGCAGA ATACTCATTTGGGAAGATGGTAGCTTAGAAATCAATAACATTACAAGGAGTGATGGAGGT GTCTATACATGCTTTGTGGAAAATAATAAAGGGAAGGCTAATAGCACTGGGACTCTTGTT ATCACAGATCCCACACGAATTATCTTGGCCCCGATTAACGCTGATATCACTGTTGGAGAA AATGCCACCATGCAGTGTGCCGCTTCCTTTGATCCTGCCCTGGATCTGACATTTGTTTGG TCCTTCAATGGTTATGTGATCGACTTTAACAAAGAGAACATTCATTACCAGCGGAATTTT ATGCTGGATTCCAATGGGGAGCTGCTCATCCGAAATGCCCAGTTGAAACACGCTGGGAGG TACACGTGCACAGCTCAGACAATTGTAGACAATTCTTCAGCCTCTGCTGACCTTGTTGTG CGAGGCCCTCCAGGCCCTCCAGGTGGTCTGCGAATAGAAGACATTAGAGCCACTTCGGTG GCACTTACTTGGAGCCGTGGTTCAGACAATCATAGTCCTATATCTAAGTACACTATCCAG ACGAAGACTATTCTTTCGGATGATTGGAAAGATGCGAAGACAGATCCCCCAATTATTGAA GGAAACATGGAGGCAGCGAGAGCAGTGGATTTAATCCCATGGATGGAATATGAATTTCGT GTGGTAGCAACCAATACATTGGGTATAGGAGAGCCCAGTATACCATCAAACAAAATTAAA ACAGATGGCGCTGCACCTAATGTGGCTCCTTCAGATGTAGGAGGTGGAGGTGGAAGCAAC AGAGAACTGACCATAACATGGGCGCCTTTGTCAAGAGAATACCATTACTTCAACAATTTT GGTTACATAGTGGCATTTAAGCCATTTGATGGGGAAGAATGGAAAAAAGTGACAGTTACT AATCCAGATACTGGCCGCTATGTCCATAAAGACGAGACCATGCGCCCTTCCACTGCATTT CAAGTCAAAGTCAAAGCTTTCAACAACAAAGGAGACGGACCCTACAGTCTCACAGCTGTC ATCCACTCCGCACAAGACGCTCCCAGTGAAGCCCCAACAGCAGTAGGAGTAAAAGTCTTA TCATCTTCTGAGATATCTGTTCATTGGGAGCATGTTGTAGAAAAAATAGTAGAAAGCTAT CAGATTCGGTACTGGGCTTCCCATGACAAAGAAGCAGCTGCACACAGAGTTCAAGTTGCT AGCCAAGAATACTCGGCCAGGCTGGAGAACCTTCTGCCTGACACCCAGTATTTTGTGGAA GTCAGGGCGTGCAATAGTGCAGGGTGTGGACCTCCCAGTGATATGACTGAGACCTTCACC AAGAAAGCACCTCCAAGCCAGCCTCCGCGGATCATCAGTTCCGTAAGGTCTGGTTCACGC TACATAATCACCTGGGATCATGTGGTTGCACTGTCAAATGAATCTACAGTGACGGGATAT AAGGTACTCTATAGACCTGATGGCCAGCATGATGGCAAGCTGTATTCAACTCATAAACAC TCCATAGAAGTCCCAATCCCCAGGGATGGAGAATATGTTGTAGAGGTTCGTGCACACAGT GATGGAGGAGATGGAGTGGTGTCTCAAGTCAAAATTTCAGGTGCATCCATCCTATCACCA TGTCTTCTCGGCTTCCTGCTGCCTGCCCTTGGCATCCTTGTCTACTTGGAATTCTGA |
| Protein Properties | |
| Number of Residues | 1018 |
| Molecular Weight | 113385.0 |
| Theoretical pI | 6.15 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Contactin-1 MKMWLLFSLLVIISFKTCLSEFTWHRRYGHGVSEEDKGFGPIFEEQPINTIYPEESPEGK VSLNCRARASPFPVYKWRMNNGDIDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNY GMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVF ITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPLPERTTKPY PADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNI QLEDEGIYECEAENNRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIP TIRWLKNGYSYHRGELRLYDVTFENAGMYQCIAENTHGAIYANAELKILALAPTFEMNPM KKKILAAKGGRVIIECKPKAAPKPTFLWSKGTERLVNSSRILIWEDGSLEINNITRSDGG VYTCFVENNKGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVW SFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVV RGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIE GNMEAARAVDLIPWMEYEFRVVATNTLGIGEPSIPSNKIKTDGAAPNVAPSDVGGGGGSN RELTITWAPLSREYHYFNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMRPSTAF QVKVKAFNNKGDGPYSLTAVIHSAQDAPSEAPTAVGVKVLSSSEISVHWEHVVEKIVESY QIRYWASHDKEAAAHRVQVASQEYSARLENLLPDTQYFVEVRACNSAGCGPPSDMTETFT KKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKH SIEVPIPRDGEYVVEVRAHSDGGDGVVSQVKISGASILSPCLLGFLLPALGILVYLEF |
| External Links | |
| GenBank ID Protein | BAA06861.1 |
| UniProtKB/Swiss-Prot ID | Q28106 |
| UniProtKB/Swiss-Prot Entry Name | CNTN1_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | D32135 |
| GeneCard ID | CNTN1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |