Showing Protein General transcription factor II-I (BMDBP02594)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP02594 |
| Secondary Accession Numbers | None |
| Name | General transcription factor II-I |
| Synonyms | Not Available |
| Gene Name | GTF2I |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Not Available |
| Specific Function | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 25 |
| Locus | Not Available |
| SNPs | GTF2I |
| Gene Sequence |
>2937 bp ATGGCCCAAGTAGCAGTGTCTACCCTGCCTGTCGAAGACGAGGAGTCCTCAGAGAGCAGG ATGGTGGTGACGTTCCTCATGTCTGCTCTTGAGTCCATGTGTAAAGAACTGGCCAAGTCC AAGGCGGAAGTAGCGTGCATCGCAGTGTATGAGACAGACGTGTTTGTTGTTGGAACCGAG AGAGGACGTGCTTTTGTCAACACTAGAAAGGACTTTCAGAAAGATTTTGTAAAATACTGT GTTGAAGAAGAAGAAAAGGCTGCAGAGATGCATAAAATGAAATCTACAGCCCAGGCAAAT CGGATGAGTGTCGATGCTGTGGAGATAGAAACACTCAGAAAAACAGTTGAGGACTATTTC TGCTTTTGCTATGGGAAAGCTTTAGGCAAGTCAACAGTGGTGCCTGTTCCATATGAAAAG ATGCTCCGAGATCAGTCGGCCGTGGTGGTGCAGGGGCTTCCAGAAGGAGTAGCCTTCAAA CACCCTGAAAACTATGATCTTGCAACCCTGAAGTGGATTTTGGAGAACAAAGCAGGGATT TCATTTATCATTAAAAGACCTTTCCTAGAGCCAAAGAAGCACCTAGGTGGTCGTGTGATG GTTACAGATGCTGAAAGGTCAATGATATCTCCAAGTGGAAGCTGTGGCCCCGTCAAAGTA AAAACAGAACCCTCAGAGGATTCTGGCATTTCTCTGGAAATGGCAGCTGTGACAGTGAAG GAAGAATCTGAAGATCCTGATTACTATCAATATAACATTCAAGCAGGCCCTTCTGAAACT GATGATGTTGATGACAAACTCCCCCTTTCGAAGTCTTTGCAAGGAAGCCATCATTCTTCA GAGGGCAATGAAGGAACAGAAATGGAAGTACCAGCAGAAGATGATGACTATCCTCCACCT GCCAAGAGACCAAAGAGCAGTGAACCTCCCCAGCCACCCGTCACAGAACCTGCGAATGCC GGCAAACGGAAAGTGAGGGAGTTCAACTTCGAGAAATGGAATGCTCGAATTACTGATCTG CGTAAACAAGTTGAAGAGTTGTTTGAAAGAAAGTATGCTCAAGCTATAAAAGCCAAAGGT CCTGTGACGATCCCGTACCCTCTTTTCCAGTCCCATGTGGAAGATCTTTATGTAGAAGGA CTTCCAGAAGGAATCCCCTTTAGAAGGCCATCAACTTATGGAATCCCTCGCCTTGAGAGG ATATTACTTGCAAAGGAAAGGATTCGTTTTGTGATTAAGAAGCATGAACTTTTGAATTCA ACACGTGAAGACTTACAGCTTGATAAACCAGCTTCAGGAGTCAAGGAAGAGTGGTATGCC AGAATCACTAAGTTACGAAAGATGGTAGATCAGCTTTTCTGTAAAAAATTTGCTGAAGCC TTAGGGAGCACCGAAGCTAAGGCTGTACCTTACCAGAAATTTGAAGCACACCCTAATGAC CTCTACGTGGAAGGACTGCCAGAAAACATTCCTTTTAGAAGTCCCTCGTGGTATGGGATC CCAAGGCTGGAAAAGATTATTCAAGTGGGCAATCGAATTAAATTTGTTATTAAAAGACCA GAGCTTCTGACGCACAGCACTACTGAAGTTACTCAGCCCAGAACGAATACACCAGTCAAA GAAGATTGGAATGTCAGAATTACCAAGCTACGGAAGCAAGTGGAAGAGATTTTTAATTTG AAATTTGCTCAAGCTCTTGGACTCACAGAAGCAGTAAAAGTACCATACCCGGTGTTTGAA TCAAACCCCGAGTTCCTCTATGTAGAAGGCTTGCCAGAAGGAATTCCCTTTCGAAGCCCT ACCTGGTTTGGAATTCCAAGACTGGAAAGGATTGTCCGTGGAAGTAATAAAATCAAGTTT GTTGTTAAAAAACCTGAACTAGTTATTTCCTACTTGCCTCCTGGAATGGCTAGTAAAATA AACACTAAAGCTTTGCAGTCCCCGAAAAGACCACGAAGCCCCGGGAGTAATTCGAAAGTT CCTGAAATTGAGGTCACTGTGGAAGGCCCTAATAATAGCAATCCTCAAACCTCAGCCGTT CGAACCCCTACCCAGACGAATGGTTCTAATGTTCCCTTCAAGCCTCGAGGGAGAGAGTTT TCCTTTGAGGCCTGGAATGCCAAAATCACAGACCTAAAACAGAAAGTTGAAAATCTTTTC AATGAAAAATGTGGTGAAGCTCTTGGCCTTAAACAAGCTGTGAAAGTGCCGTTCGCGTTA TTTGAGTCTTTCCCAGAAGACTTTTATGTGGAAGGCTTACCCGAGGGTGTGCCATTCCGA CGACCGTCTACTTTTGGCATTCCAAGGCTGGAGAAGATACTCAGAAACAAAGCCAAAATT AAGTTCATCATTAAAAAGCCAGAAATGTTTGAGACTGCAATTAAGGAGAGCACCTCCTCA TCTAAGAGCCCTCCAAGAAAAATCAATTCATCACCCAGTGTTAATACTACTGCATCAGGT GTTGAAGACCTTAACATCATTCAGGTGACAATTCCAGACGATGATAATGAAAGACTATCA AAAGTTGAAAAAGCTCGACAGCTAAGAGAGCAAGTTAATGACCTCTTCAGTCGAAAATTT GGTGAAGCCATTGGGATGGGTTTCCCCGTGAAGGTTCCTTACAGGAAAATCACAATTAAC CCTGGCTGTGTGGTGGTTGATGGCATGCCCCCCGGAGTGTCATTCAAAGCCCCCAGCTAT CTGGAAATCAGCTCCATGAGAAGGATCTTAGATTCTGCTGAGTTCATTAAATTCACAGTC ATTAGACCATTTCCAGGACTTGTGATTAATAACCAGTTGGTTGATCAGAATGAGTCAGAA GGCCCAGTGATCCAAGAATCAGCTGAGCCAACCCAGTTGGAGGTTCCTGCAACCGAAGAA ATAAAGGAGACTGATGGAAACTCCCAAATCAAGCAAGAACCAGACCCTACGTGGTAG |
| Protein Properties | |
| Number of Residues | 978 |
| Molecular Weight | 110125.0 |
| Theoretical pI | 7.47 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>General transcription factor II-I MAQVAVSTLPVEDEESSESRMVVTFLMSALESMCKELAKSKAEVACIAVYETDVFVVGTE RGRAFVNTRKDFQKDFVKYCVEEEEKAAEMHKMKSTAQANRMSVDAVEIETLRKTVEDYF CFCYGKALGKSTVVPVPYEKMLRDQSAVVVQGLPEGVAFKHPENYDLATLKWILENKAGI SFIIKRPFLEPKKHLGGRVMVTDAERSMISPSGSCGPVKVKTEPSEDSGISLEMAAVTVK EESEDPDYYQYNIQAGPSETDDVDDKLPLSKSLQGSHHSSEGNEGTEMEVPAEDDDYPPP AKRPKSSEPPQPPVTEPANAGKRKVREFNFEKWNARITDLRKQVEELFERKYAQAIKAKG PVTIPYPLFQSHVEDLYVEGLPEGIPFRRPSTYGIPRLERILLAKERIRFVIKKHELLNS TREDLQLDKPASGVKEEWYARITKLRKMVDQLFCKKFAEALGSTEAKAVPYQKFEAHPND LYVEGLPENIPFRSPSWYGIPRLEKIIQVGNRIKFVIKRPELLTHSTTEVTQPRTNTPVK EDWNVRITKLRKQVEEIFNLKFAQALGLTEAVKVPYPVFESNPEFLYVEGLPEGIPFRSP TWFGIPRLERIVRGSNKIKFVVKKPELVISYLPPGMASKINTKALQSPKRPRSPGSNSKV PEIEVTVEGPNNSNPQTSAVRTPTQTNGSNVPFKPRGREFSFEAWNAKITDLKQKVENLF NEKCGEALGLKQAVKVPFALFESFPEDFYVEGLPEGVPFRRPSTFGIPRLEKILRNKAKI KFIIKKPEMFETAIKESTSSSKSPPRKINSSPSVNTTASGVEDLNIIQVTIPDDDNERLS KVEKARQLREQVNDLFSRKFGEAIGMGFPVKVPYRKITINPGCVVVDGMPPGVSFKAPSY LEISSMRRILDSAEFIKFTVIRPFPGLVINNQLVDQNESEGPVIQESAEPTQLEVPATEE IKETDGNSQIKQEPDPTW |
| External Links | |
| GenBank ID Protein | AAI51388.1 |
| UniProtKB/Swiss-Prot ID | A7MB80 |
| UniProtKB/Swiss-Prot Entry Name | GTF2I_BOVIN |
| PDB IDs | |
| GenBank Gene ID | BC151387 |
| GeneCard ID | GTF2I |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |