Showing Protein Cytokine-inducible SH2-containing protein (BMDBP02599)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP02599 |
| Secondary Accession Numbers | None |
| Name | Cytokine-inducible SH2-containing protein |
| Synonyms | Not Available |
| Gene Name | CISH |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in intracellular signaling cascade |
| Specific Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation (By similarity). May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 22 |
| Locus | Not Available |
| SNPs | CISH |
| Gene Sequence |
>765 bp ATGGTCCTCTGCGTTCAGGGACTTTGTCCTTTGCTGGCCGTGGAGCAGATTGGGCAGCGG CCCCTGTGGGCCCAGTCCCTGGAGCTGCCCCAGCAAGTTATGCAGCCTTTGTCTGCTGGC GCCTTCCTGGAGGAGGCAGTAGAGGAGTCCCCAGCCCAGCCAGAGAGGGAGCCCAAGGTG GTGGACCCCGAGGAGGACCTGCTGTGCATAGCCAAGACCTTCTCCTACCTTCGGGAATCT GGCTGGTACTGGGGTTCCATTACGGCCAGTGAGGCCCGGCAACACCTTCAGAAGATGCCA GAGGGCACCTTCCTGGTACGTGACAGCACCCACCCCAGCTACCTGTTCACACTGTCCGTC AAGACCACCCGCGGGCCCACCAACGTGCGCATTGAGTACGCCGACTCCAGCTTCCGCCTG GACTCCAACTGCCTGTCCAGGCCTCGCATCCTGGCCTTCCCAGATGTGGTGAGCCTGGTC CAGCACTACGTGGCCTCCTGTGCTGCAGACACCCGGAGTGACAGTCCCGACCTTGCCACC ACCCCGGCCCTGCCCACCCCGAAGGAAGATGCGCCCGGTGACCCAGCCCTGCCCGCCACG GCCGTTCACCTGAAACTGGTACAGCCCTTTGTGCGCAGGAGCAGCACCCGGAGCCTGCAG CACCTGTGCCGCCTGGTCATCAACCGCCTGGTGGTCGACGTGGACTGCCTGCCGCTTCCC CGGCGCATGGCTGACTACCTCCGACAATACCCCTTCCAGCTCTGA |
| Protein Properties | |
| Number of Residues | 254 |
| Molecular Weight | 28397.0 |
| Theoretical pI | 6.03 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Cytokine-inducible SH2-containing protein MVLCVQGLCPLLAVEQIGQRPLWAQSLELPQQVMQPLSAGAFLEEAVEESPAQPEREPKV VDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSV KTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCAADTRSDSPDLAT TPALPTPKEDAPGDPALPATAVHLKLVQPFVRRSSTRSLQHLCRLVINRLVVDVDCLPLP RRMADYLRQYPFQL |
| External Links | |
| GenBank ID Protein | AAI13308.1 |
| UniProtKB/Swiss-Prot ID | Q2HJ53 |
| UniProtKB/Swiss-Prot Entry Name | CISH_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC113307 |
| GeneCard ID | CISH |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |