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Record Information
Version1.0
Creation Date2016-09-30 22:18:28 UTC
Update Date2020-05-21 16:28:51 UTC
BMDB IDBMDB0000015
Secondary Accession Numbers
  • BMDB00015
Metabolite Identification
Common NameCortexolone
DescriptionCortexolone, also known as cortodoxone or 11 deoxycortisol, belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone. Thus, cortexolone is considered to be a steroid lipid molecule. Cortexolone is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Cortexolone is a potentially toxic compound.
Structure
Thumb
Synonyms
ValueSource
11-Desoxy-17-hydroxycorticosteroneChEBI
CortodoxoneChEBI
Reichstein substance SHMDB
Substance S, reichstein'sHMDB
11 DeoxycortisolHMDB
11 DesoxycortisolHMDB
11 DesoxycortisoneHMDB
S, Reichstein's substanceHMDB
11-DesoxycortisolHMDB
11-DesoxycortisoneHMDB
Reichsteins substance SHMDB
11-DeoxycortisolHMDB
SK&F 3050HMDB
Reichstein's substance SHMDB
11-Deoxy-17-hydroxycorticosteroneHMDB
11-DeoxyhydrocortisoneHMDB
11-DesoxyhydrocortisoneHMDB
17,21-Dihydroxy-4-pregnene-3,20-dioneHMDB
17,21-Dihydroxypregn-4-ene-3,20-dioneHMDB
17,21-DihydroxyprogesteroneHMDB
17-Hydroxy-11-deoxycorticosteroneHMDB
17alpha-HydroxycortexoneHMDB
20-Dione 17,21-dihydroxypregn-4-ene-3HMDB
4-Pregnene-17alpha,21-diol-3,20-dioneHMDB
Compound SHMDB
11-Deoxy-17-hydrocorticosteroneHMDB
11-DeoxycortisoneHMDB
11-Desoxy-17α-hydroxycorticosteroneHMDB
11-Desoxy-17alpha-hydroxycorticosteroneHMDB
17,21-Dihydroxypregn-4-en-3,20-dioneHMDB
17Α,21-dihydroxy-4-pregnen-3,20-dioneHMDB
17Α,21-dihydroxypregn-4-ene-3,20-dioneHMDB
17Α,21-dihydroxyprogesteroneHMDB
17Α-hydroxycortexoneHMDB
4-Pregnen-17α,21-diol-3,20-dioneHMDB
4-Pregnene-17α,21-diol-3,20-dioneHMDB
17alpha,21-Dihydroxy-4-pregnen-3,20-dioneHMDB
17alpha,21-Dihydroxypregn-4-ene-3,20-dioneHMDB
17alpha,21-DihydroxyprogesteroneHMDB
4-Pregnen-17alpha,21-diol-3,20-dioneHMDB
CortexoloneMeSH
Chemical FormulaC21H30O4
Average Molecular Weight346.4605
Monoisotopic Molecular Weight346.214409448
IUPAC NameNot Available
Traditional NameNot Available
CAS Registry NumberNot Available
SMILESNot Available
InChI Identifier
InChI=1S/C21H30O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h11,15-17,22,25H,3-10,12H2,1-2H3/t15-,16+,17+,19+,20+,21+/m1/s1
InChI KeyWHBHBVVOGNECLV-OBQKJFGGSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassHydroxysteroids
Direct Parent21-hydroxysteroids
Alternative Parents
Substituents
  • 21-hydroxysteroid
  • Progestogin-skeleton
  • Pregnane-skeleton
  • 20-oxosteroid
  • 3-oxo-delta-4-steroid
  • 3-oxosteroid
  • 17-hydroxysteroid
  • Oxosteroid
  • Delta-4-steroid
  • Cyclohexenone
  • Alpha-hydroxy ketone
  • Tertiary alcohol
  • Cyclic alcohol
  • Cyclic ketone
  • Ketone
  • Organic oxygen compound
  • Organooxygen compound
  • Primary alcohol
  • Carbonyl group
  • Hydrocarbon derivative
  • Alcohol
  • Organic oxide
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors
Ontology
StatusDetected but not Quantified
Origin
  • Endogenous
  • Exogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Cell membrane
  • Cytoplasm
  • Endoplasmic reticulum
  • Membrane
  • Mitochondria
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted PropertiesNot Available
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
Biological Properties
Cellular Locations
  • Cell membrane
  • Cytoplasm
  • Endoplasmic reticulum
  • Membrane
  • Mitochondria
Biospecimen Locations
  • All Tissues
  • Blood
  • Liver
  • Mammary Gland
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
All TissuesExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
details
BloodDetected but not QuantifiedNot QuantifiedNot SpecifiedNot Specified
Normal
details
LiverDetected but not QuantifiedNot QuantifiedNot SpecifiedNot Specified
Normal
details
LiverDetected but not QuantifiedNot QuantifiedNot SpecifiedNot Specified
Normal
details
Mammary GlandDetected but not QuantifiedNot QuantifiedNot SpecifiedNot Specified
Normal
details
Mammary GlandDetected but not QuantifiedNot QuantifiedNot SpecifiedNot Specified
Normal
details
Abnormal Concentrations
Not Available
HMDB IDHMDB0000015
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB021872
KNApSAcK IDNot Available
Chemspider ID389582
KEGG Compound IDC05488
BioCyc IDNot Available
BiGG ID45914
Wikipedia LinkCortexolone
METLIN ID5088
PubChem Compound440707
PDB IDNot Available
ChEBI ID28324
References
Synthesis ReferenceLuu, Duc Huy. New method for the synthesis of Reichstein's compound S from pregnene. Tap Chi Duoc Hoc (2002), (9), 23-25.
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

General function:
Secondary metabolites biosynthesis, transport and catabolism
Specific function:
A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11-deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
Gene Name:
CYP11B1
Uniprot ID:
P15150
Molecular weight:
57847.0
Reactions
Cortexolone + Oxygen + Reduced adrenal ferredoxin → Cortisol + Water + Oxidized adrenal ferredoxindetails
General function:
Secondary metabolites biosynthesis, transport and catabolism
Specific function:
Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.
Gene Name:
CYP21
Uniprot ID:
P00191
Molecular weight:
56077.0
Reactions
17-Hydroxyprogesterone + Oxygen + Reduced acceptor → Cortexolone + Water + Acceptordetails