Showing metabocard for Folic acid (BMDB0000121)

General function:

Coenzyme transport and metabolism

Specific function:

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2 (By similarity).

Gene Name:

DHFR

Uniprot ID:

P00376

Molecular weight:

21604.0

Reactions

General function:

Involved in folic acid binding

Specific function:

Not Available

Gene Name:

SLC19A1

Uniprot ID:

Q17QC9

Molecular weight:

56622.0

General function:

Involved in folic acid binding

Specific function:

Not Available

Gene Name:

SLC19A3

Uniprot ID:

A7E352

Molecular weight:

54249.0

General function:

Involved in folic acid binding

Specific function:

Not Available

Gene Name:

SLC19A1

Uniprot ID:

Q0V8L3

Molecular weight:

34009.0

General function:

Involved in receptor activity

Specific function:

Not Available

Gene Name:

FOLR2

Uniprot ID:

Q0VCN9

Molecular weight:

29333.0

General function:

Involved in folic acid binding

Specific function:

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation (By similarity).

Gene Name:

FOLR1

Uniprot ID:

P02702

Molecular weight:

27922.0