Showing metabocard for L-Kynurenine (BMDB0000684)

General function:

Transcription

Specific function:

Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) (By similarity).

Gene Name:

AADAT

Uniprot ID:

Q5E9N4

Molecular weight:

47901.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity).

Gene Name:

KYAT3

Uniprot ID:

Q0P5G4

Molecular weight:

51472.0

General function:

Not Available

Specific function:

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.

Gene Name:

KYNU

Uniprot ID:

F1MCH2

Molecular weight:

52186.0

Reactions

General function:

Not Available

Specific function:

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.

Gene Name:

AFMID

Uniprot ID:

E1BLL5

Molecular weight:

35460.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

KMO

Uniprot ID:

E1BN59

Molecular weight:

51032.0

Reactions