Showing metabocard for L-Leucine (BMDB0000687)

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

BCAT1

Uniprot ID:

A4IFQ7

Molecular weight:

43185.0

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity).

Gene Name:

BCAT2

Uniprot ID:

Q5EA40

Molecular weight:

44648.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

BCAT2

Uniprot ID:

Q0V8J6

Molecular weight:

44274.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

BCAT2

Uniprot ID:

Q5E9U7

Molecular weight:

40447.0

General function:

Involved in protein dimerization activity

Specific function:

Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors.

Gene Name:

ATF4

Uniprot ID:

Q3ZCH6

Molecular weight:

38245.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

SLC7A5

Uniprot ID:

Q9TU26

Molecular weight:

55110.0