Showing metabocard for L-Tryptophan (BMDB0000929)

General function:

Amino acid transport and metabolism

Specific function:

Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.

Gene Name:

TDO2

Uniprot ID:

Q2KIQ5

Molecular weight:

47708.0

Reactions

General function:

Translation, ribosomal structure and biogenesis

Specific function:

T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity).

Gene Name:

WARS1

Uniprot ID:

P17248

Molecular weight:

53812.0

Reactions

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis.

Gene Name:

WARS2

Uniprot ID:

Q3T099

Molecular weight:

40205.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Gene Name:

DDC

Uniprot ID:

P27718

Molecular weight:

54294.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

SLC7A5

Uniprot ID:

Q9TU26

Molecular weight:

55110.0